Comprehensive two-dimensional liquid chromatography as a biomimetic screening platform for pharmacokinetic profiling of compound libraries in early drug development

Russo, Giacomo; Grumetto, Lucia; Baert, Mathijs; Lynen, Frédéric

doi:10.1016/j.aca.2020.11.003

Cited by 6 publications

(1 citation statement)

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“…The in situ gels showed sustained in vitro release of nifedipine where about 76% of the loaded drug was released over 12 h and a 70.5 ± 5.04% reduction in the IOP (control marketed timolol maleate eye drop: 45.83 ± 2.91%), with no sign of toxicity or irritation to the eye in rabbits. The hydrophobic nature of nifedipine (LogP and LogD: 3.17) 68 and hydroxypropyl methylcellulose form tight gel structures via hydrogen bonding in the aqueous solution, which delays the release rate of the drug.…”

Section: Polysaccharide-based Formulations For Glaucoma Treatmentmentioning

confidence: 99%

Polysaccharides polymers for glaucoma treatment-a review

Ahmed,

Islam,

Monalisa

et al. 2023

European Journal of Ophthalmology

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One of the major challenges in preventing glaucoma progression is patient compliance with medication regimens. Since conventional ophthalmic dosage forms have numerous limitations, researchers have been intensively working on developing polymers-based delivery systems for glaucoma drugs. Specifically, research and development efforts have increased using polysaccharide polymers such as sodium alginate, cellulose, β-cyclodextrin, hyaluronic acid, chitosan, pectin, gellan gum, galactomannans for sustained release to the eye to overcome treatment challenges, showing promise in improving drug release and delivery, patient experience, and treatment compliance. In the recent past, multiple research groups have successfully designed sustained drug delivery systems, promoting the efficacy as well as the feasibility of glaucoma drugs with single/combinations of polysaccharides to eliminate the drawbacks associated with the glaucoma treatment. Naturally available polysaccharides, when used as drug vehicles can increase the retention time of eye drops on the ocular surface, leading to improved drug absorption and bioavailability. Additionally, some polysaccharides can form gels or matrices that can release drugs slowly over time, providing sustained drug delivery and reducing the need for frequent dosing. Thus, this review aims to provide an overview of the pre-clinical and clinical studies of polysaccharide polymers applied for glaucoma treatment along with their therapeutic outcomes.

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Section: Polysaccharide-based Formulations For Glaucoma Treatmentmentioning

confidence: 99%