Comprehensive two-dimensional gas chromatography in forensic science: A critical review of recent trends

Gruber, Beate; Weggler, Benedikt; Jaramillo, Roman; Murrell, Kyra A.; Dorman, Frank L.

doi:10.1016/j.trac.2018.05.017

Cited by 66 publications

(30 citation statements)

References 63 publications

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“…Forensic science comprises a wide variety of analysis objectives, such as human scent and remains, criminal environmental pollution, arson and explosives, illicit drugs, etc. [3,144]. Several studies exploring the potential of GC×GC and MDGC techniques in this field have been published, as reviewed by Gruber et al [144], although some limitations such as method standardisation, consistency and interpretation of results are still faced.…”

Section: Forensicsmentioning

confidence: 99%

The Blossoming of Technology for the Analysis of Complex Aroma Bouquets—A Review on Flavour and Odorant Multidimensional and Comprehensive Gas Chromatography Applications

Amaral

Marriott

2019

Molecules

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Multidimensional approaches in gas chromatography have been established as potent tools to (almost) attain fully resolved analyses. Flavours and odours are important application fields for these techniques since they include complex matrices, and are of interest for both scientific study and to consumers. This article is a review of the main research studies in the above theme, discussing the achievements and challenges that demonstrate a maturing of analytical separation technology.

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Section: Forensicsmentioning

confidence: 99%

The Blossoming of Technology for the Analysis of Complex Aroma Bouquets—A Review on Flavour and Odorant Multidimensional and Comprehensive Gas Chromatography Applications

Amaral

Marriott

2019

Molecules

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“…Two chromatographic columns with different polarities were used to separate the compounds with similar boiling points, but different polarities . Thus, the co‐eluting peaks indicative of the compositions are effectively resolved, and the peak capacity of the GC is greatly improved . The chromatographic peak from the first dimension column is cut, concentrated, and re‐injected into the second dimension column; thus, the peak width is significantly reduced to achieve an increased signal response and sensitivity .…”

Section: Introductionmentioning

confidence: 99%

“…The chromatographic peak from the first dimension column is cut, concentrated, and re‐injected into the second dimension column; thus, the peak width is significantly reduced to achieve an increased signal response and sensitivity . Recently, GC × GC fingerprint analysis has been adapted for mainly illicit drug analysis and decomposition profiling, as well as for arson and explosives investigations, whereas targeted analysis has been utilized extensively in environmental studies . In addition, GC × GC is also used to analyze natural products.…”

Section: Introductionmentioning

confidence: 99%

Determination and comparison of agarwood from different origins by comprehensive two‐dimensional gas chromatography–quadrupole time‐of‐flight mass spectrometry

Sun

Zhang

Liu

et al. 2020

J of Separation Science

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Agarwood, a species of resinous heartwood, is a precious medicinal plant and a type of rare natural spice, which is widely used in medicine, cosmetics, religious activities, and other fields. In this study, agarwood samples from eight different regions across four countries were analyzed by comprehensive two-dimensional gas chromatography−quadrupole time-of-flight mass spectrometry. A total of 232 species were identified (the match factors of these compounds were above 750). The main compounds of agarwood are oxygenated sesquiterpenes and chromones. The compositions of India1 and Malaysia2 were significantly different from those of other samples, which might be attributed to the different production processes of agarwood.For further investigation, factor analysis was conducted for six agarwood samples. The results showed that the data classification possessed a regional characteristic;according to the retention time and relative content, characteristic compositions were determined by factor scores. Finally, the differences of characteristic compositions were simply analyzed, and the reasons were speculated. K E Y W O R D Sagarwood, comprehensive two-dimensional, factor analysis, gas chromatography, regional characteristic compositions 1284

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“…Comprehensive two-dimensional gas chromatography (GC×GC) coupled to time-of-flight mass spectrometry (TOFMS) has become an established technique for the analysis of complex samples [1][2][3]. The increased peak capacity and sensitivity obtained through non-targeted GC×GC-TOFMS analysis result in complex data sets, which are time-consuming to analyze [4,5].…”

Section: Introductionmentioning

confidence: 99%

Comparison of Pre-Processing and Variable Selection Strategies in Group-Based GC×GC-TOFMS Analysis

Piotrowski

Place

2019

Separations

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Chemometric analysis of comprehensive two-dimensional chromatography coupled to time-of-flight mass spectrometry (GC×GC-TOFMS) data has been reported with various workflows, yet little effort has been devoted to evaluating the impacts of workflow variation on study conclusions. The report presented herein aims to investigate the effects of different pre-processing and variable selection strategies on the scores’ plot outputs from GC×GC-TOFMS data acquired from lavender and tea tree essential oils. Our results suggest that pre-processing, such as applying log transformation to the data set, can result in significant differentiation of sample clustering when compared to only mean centering. Additionally, exploring differences between analysis of variance, Fisher-ratio, and partial least squares-discriminant analysis feature selection resulted in little variation in scores plots. This work highlights the effects different chemometric workflows can have on results to help facilitate harmonization efforts.

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Comprehensive two-dimensional gas chromatography in forensic science: A critical review of recent trends

Cited by 66 publications

References 63 publications

The Blossoming of Technology for the Analysis of Complex Aroma Bouquets—A Review on Flavour and Odorant Multidimensional and Comprehensive Gas Chromatography Applications

The Blossoming of Technology for the Analysis of Complex Aroma Bouquets—A Review on Flavour and Odorant Multidimensional and Comprehensive Gas Chromatography Applications

Determination and comparison of agarwood from different origins by comprehensive two‐dimensional gas chromatography–quadrupole time‐of‐flight mass spectrometry

Comparison of Pre-Processing and Variable Selection Strategies in Group-Based GC×GC-TOFMS Analysis

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