Comprehensive two-dimensional gas chromatography for determining the effect of electron beam treatment of polypropylene used for food packaging

Biedermann, Maurus; Castillo, Roberto; Riquet, Anne‐Marie; Grob, Koni

doi:10.1016/j.polymdegradstab.2013.10.021

Cited by 33 publications

(26 citation statements)

References 28 publications

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“…However, this concept is not properly applicable to saturated hydrocarbons, as steric effects dominate polarity. In fact, as shown by Vendeuvre et al (2004), van der Westhuizen et al (2010van der Westhuizen et al ( , 2011 and Biedermann et al (2014), the reverse configuration is preferable for the analysis of the MOSH, i.e. a first separation on a polar stationary phase and a second on a non-polar one.…”

Section: Selectivity Of the Gcxgc System Usedmentioning

confidence: 99%

Bioaccumulation and toxicity of mineral oil hydrocarbons in rats ‐ specificity of different subclasses of a broad mixture relevant for human dietary exposures

Cravedi¹,

Grob²,

Nygaard

et al. 2017

EFSA Supporting Publications

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The purpose of this study was to investigate the fate and effects of mineral oil saturated hydrocarbons (MOSH) in female Fischer 344 rats. Animals were fed control diet or diet containing various MOSH mixtures at concentrations ranging from 40 to 4000 mg/kg feed for up to 120 days. MOSH were analysed in liver, spleen, adipose tissue and remaining carcass at different sampling times. In addition to clinical effects, liver microgranulomas, hepatic inflammation, and disruption of the immune function were the main toxicological endpoints investigated. Arthritis symptoms were specifically studied in dark agouti rats. The results indicate that accumulation of MOSH depends on the mixture tested but always occurred predominantly in the liver and to a lesser extent in adipose tissue and spleen. Strong differences exist between liver and adipose tissue in terms of accumulated hydrocarbons: whereas in adipose tissue the accumulated fraction corresponds to the most volatile part of the administered mixture, in the liver, the most volatile as well as the highest boiling part of the mixture are almost absent. Also the types of hydrocarbons differ. When exposure ceases, a significant decrease of MOSH concentration was observed in the liver, but not in adipose tissue. MOSH exposure results in a significant increase in absolute and relative liver weights, the effect being dose-related, but also dependent on the mixture tested. There were large differences in the ability of the different mixtures to induce liver granulomas. The highest incidence was observed with the mixture containing the highest proportion of n-alkanes, suggesting that this fraction could play a significant role in the development of hepatic granulomas. No effects were found on the immune function, irrespective of the mixture or the dose tested.

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Section: Selectivity Of the Gcxgc System Usedmentioning

confidence: 99%

Bioaccumulation and toxicity of mineral oil hydrocarbons in rats ‐ specificity of different subclasses of a broad mixture relevant for human dietary exposures

Cravedi¹,

Grob²,

Nygaard

et al. 2017

EFSA Supporting Publications

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“…The first was probably a product of the oxidation of 2,6-di-tert-butylphenol, a by-product of Irganox 1076 identified in non-treated material, and the second would be a cleavage product of the additive's CO bond (Biedermann, Castillo, Riquet, & Grob, 2014). As to the films enriched with Tinuvin 326, the main degradation product identified following an electron-beam treatment, seemed to be the result of a substitution of chlorine with hydrogen.…”

Section: Behavior Of Additives In Experimental Materialsmentioning

confidence: 99%

The consequences of physical post-treatments (microwave and electron-beam) on food/packaging interactions: A physicochemical and toxicological approach

Riquet

Breysse²,

Dahbi

et al. 2016

Food Chemistry

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a b s t r a c tThe safety of microwave and electron-beam treatments has been demonstrated, in regards to the formation of reaction products that could endanger human health. An integrated approach was used combining the potential toxicity of all the substances likely to migrate to their chemical characterizations. This approach was applied to polypropylene (PP) films prepared with a selection of additives. Components were identified by liquid and gas chromatography using a mass selective detector system. Their potential toxicity was assessed using three in vitro short-term bioassays and their migrations were carried out using a standards-based approach. After the electron-beam treatment some additives decomposed and there was a significant increase in the polyolefin oligomeric saturated hydrocarbons concentration. PP prepared with Irgafos 168 led to a significantly strong cytotoxic effect and PP prepared with Irganox 1076 induced a dose-dependant estrogenic effect in vitro. Migration values were low and below the detection limit of the analytical method applied.

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“…The POH were preseparated by the above HPLC method; instead of on-line transfer to GC, the fractions were collected from the dismounted transfer line into 1.5 ml autosampler vials. They were reconcentrated by a stream of nitrogen according to the sensitivity required; 10 l were injected on-column as described in [25].…”

Section: Characterization By Comprehensive Two-dimensional Gcmentioning

confidence: 99%

“…In a preliminary overview, 11 polyolefin granulates (PE: n = 8; PP: n = 3) contained 5-40% (average 25%) POMH among the oligomers C [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35] . The first example shown in more detail is from the extract of a LDPE granulate (Fig.…”

Section: Polyolefin Granulatesmentioning

confidence: 99%

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Argentation high performance liquid chromatography on-line coupled to gas chromatography for the analysis of monounsaturated polyolefin oligomers in packaging materials and foods

Lommatzsch

Biedermann²,

Simat

et al. 2015

Journal of Chromatography A

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Comprehensive two-dimensional gas chromatography for determining the effect of electron beam treatment of polypropylene used for food packaging

Cited by 33 publications

References 28 publications

Bioaccumulation and toxicity of mineral oil hydrocarbons in rats ‐ specificity of different subclasses of a broad mixture relevant for human dietary exposures

Bioaccumulation and toxicity of mineral oil hydrocarbons in rats ‐ specificity of different subclasses of a broad mixture relevant for human dietary exposures

The consequences of physical post-treatments (microwave and electron-beam) on food/packaging interactions: A physicochemical and toxicological approach

Argentation high performance liquid chromatography on-line coupled to gas chromatography for the analysis of monounsaturated polyolefin oligomers in packaging materials and foods

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