Comprehensive treatments for social cognitive deficits in schizophrenia: A critical review and effect-size analysis of controlled studies

Kurtz, Matthew M.; Gagen, Emily C.; Rocha, Nuno; Machado, Sérgio; Penn, David L.

doi:10.1016/j.cpr.2015.09.003

Cited by 161 publications

(151 citation statements)

References 61 publications

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“…This may be particularly important among patients with pediatric-onset MS. Social cognitive skills are likely to still be developing in these young people and early deficits may be more damaging for the development of social skills in the longer term. Social cognitive training has been shown to be effective in other disorders 52 and it is hoped that the results of this review can potentially help inform the development of similar interventions for those with MS.…”

Section: Resultsmentioning

confidence: 99%

Social cognition in multiple sclerosis

et al. 2016

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Objective: To quantify the magnitude of deficits in theory of mind (ToM) and facial emotion recognition among patients with multiple sclerosis (MS) relative to healthy controls.Methods: An electronic database search of Ovid MEDLINE, PsycINFO, and Embase was conducted from inception to April 1, 2016. Eligible studies were original research articles published in peer-reviewed journals that examined ToM or facial emotion recognition among patients with a diagnosis of MS and a healthy control comparison group. Data were independently extracted by 2 authors. Effect sizes were calculated using Hedges g.Results: Twenty-one eligible studies were identified assessing ToM (12 studies) and/or facial emotion recognition (13 studies) among 722 patients with MS and 635 controls. Deficits in both ToM (g 5 20.71, 95% confidence interval [CI] 20.88 to 20.55, p , 0.001) and facial emotion recognition (g 5 20.64, 95% CI 20.81 to 20.47, p , 0.001) were identified among patients with MS relative to healthy controls. The largest deficits were observed for visual ToM tasks and for the recognition of negative facial emotional expressions. Older age predicted larger emotion recognition deficits. Other cognitive domains were inconsistently associated with social cognitive performance.Conclusions: Social cognitive deficits are an overlooked but potentially important aspect of cognitive impairment in MS with potential prognostic significance for social functioning and quality of life. Further research is required to clarify the longitudinal course of social cognitive dysfunction, its association with MS disease characteristics and neurocognitive impairment, and the MSspecific neurologic damage underlying these deficits.

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Section: Resultsmentioning

confidence: 99%

Social cognition in multiple sclerosis

et al. 2016

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“…In aggregate, there is evidence of a positive effect of social cognitive training, mainly in facial emotion recognition and theory of mind domains [67]. Recently, computerized online social cognitive games and virtual reality have been used, revealing high patient satisfaction [79].…”

Section: Psychosocial Interventionsmentioning

confidence: 99%

“…Available programs differ on key characteristics, namely duration training, group size, and social cognition domains involved [67]. For example, Metacognitive Training (MCT) is a group intervention focused on cognitive biases (e.g.…”

Section: Psychosocial Interventionsmentioning

confidence: 99%

Facial emotion processing in schizophrenia: a review of behavioural and neural correlates

Grave¹,

Soares²,

Martins³

et al. 2017

IJCNMH

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Schizophrenia is one of the most severe psychiatric conditions, often associated with deficits in social cognition. Social cognition deficits are predictors of functionality in patients and involve theory of mind, attributional style, social perception, and emotional processing. In particular, facial emotion processing (an important domain of emotional processing) seems to be particularly related to cognitive and social functioning, and to positive and negative symptoms. Patients with schizophrenia have difficulties in processing emotional faces; however, those impairments are still far from fully understood. In this review, we addressed the behavioural and neural correlates of facial emotion processing in schizophrenia. Despite studies showing impairments in both positive and negative faces, the most consistent findings involved negative faces. Moreover, patients with schizophrenia showed abnormalities in the social brain neural circuit during facial emotion processing. While some studies described hypoactivation of brain areas related to emotional processing, such as the amygdala, others reported hyperactivation, leading to a high number of inconsistencies. The findings are limited by the experimental designs used, and the clinical and demographic characteristics of patients. Despite such variable findings, there has been growing interest in developing psychosocial interventions focused directly on social cognitive impairments in schizophrenia, with potential impact on patient's ability to perceive emotional faces. We provide a critical perspective on current evidence and suggest new pathways of research. The understanding of the mechanisms underlying facial emotion processing in schizophrenia could enhance functionality and quality of life by providing innovative approaches to the interpersonal difficulties patients frequently experience.

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“…Deficits in social cognition are well evidenced in schizophrenia, both in the established illness [12] and prior to illness onset [9,13], suggesting that they are relatively stable [14]. Thus, an understanding of social cognitive impairments in schizophrenia may provide opportunities for targeted recovery-focused interventions [15]. Studies of social cognition in schizophrenia may also provide more general insight into the mechanisms underlying the disorder, as these impairments have trait-like qualities that precede the onset of illness and are candidate endophenotypes [16,17].…”

Section: Social Cognitionmentioning

confidence: 99%

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2016

IJCNMH

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Although functional recovery could be advocated as an achievable treatment goal, many effective interventions for the treatment of psychotic symptoms, such as antipsychotic drugs, may not improve functioning. The last two decades of cognitive and clinical research on schizophrenia were a turning point for the firm acknowledgment of how relevant social cognitive deficits and negative symptoms could be in predicting psychosocial functioning. The relevance of social cognition dysfunction in schizophrenia patients' daily living is now unabated. In fact, social cognition deficits could be the most significant predictor of functionality in patients with schizophrenia, non-redundantly with neurocognition. Emerging evidence suggests that negative symptoms appear to play an indirect role, mediating the relationship between neurocognition and social cognition with functional outcomes. Further explorations of this mediating role of negative symptoms have revealed that motivational deficits appear to be particularly important in explaining the relationship between both neurocognitive and social cognitive dysfunction and functional outcomes in schizophrenia. In this paper we will address the relative contribution of two key constructs-social cognitive deficits and negative symptoms, namely how intertwined they could be in daily life functioning of patients with schizophrenia.

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Comprehensive treatments for social cognitive deficits in schizophrenia: A critical review and effect-size analysis of controlled studies

Cited by 161 publications

References 61 publications

Social cognition in multiple sclerosis

Social cognition in multiple sclerosis

Facial emotion processing in schizophrenia: a review of behavioural and neural correlates

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