Comprehensive treatment strategy for diesel truck exhaust

Li, Tian; Yang, Huiwen; Xu, Li; Zhou, Yuting; Min, Yongjun; Yan, Shicheng; Zhang, Yonghui; Wang, Xiaoming

doi:10.1007/s11356-023-26506-3

Cited by 4 publications

(1 citation statement)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The most common fuel in private road passenger transport is gasoline, whereas diesel is the most common fuel in public road passenger and freight transit [ 4 ]. Most of the existing heavy-duty vehicles and some types of medium- and light-duty vehicles, including public buses, trucks, machinery, etc., are run with diesel [ 5 ]. Diesel vehicles emit a higher proportion of BC and NOx compared to gasoline vehicles [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Lipid Dysregulation Induced by Gasoline and Diesel Exhaust Exposure and the Interaction with Age

Gao,

Zhang,

et al. 2024

Toxics

View full text Add to dashboard Cite

Limited knowledge exists regarding gasoline and diesel exhaust effects on lipid metabolism. This study collected gasoline and diesel exhaust under actual driving conditions and conducted inhalation exposure on male young and middle-aged C57BL/6J mice for 4 h/day for 5 days to simulate commuting exposure intensity. Additionally, PM2.5 from actual roadways, representing gasoline and diesel vehicles, was generated for exposure to human umbilical vein endothelial cells (HUVECs) and normal liver cells (LO2) for 24, 48, and 72 h to further investigate exhaust particle toxicity. Results showed that diesel exhaust reduced total cholesterol and low-density lipoprotein cholesterol levels in young mice, indicating disrupted lipid metabolism. Aspartate aminotransferase and alanine aminotransferase levels increased by 53.7% and 21.7%, respectively, suggesting potential liver injury. Diesel exhaust exposure decreased superoxide dismutase and increased glutathione peroxidase levels. Cell viability decreased, and reactive oxygen species levels increased in HUVECs and LO2 following exposure to exhaust particles, with dose- and time-dependent effects. Diesel exhaust particles exhibited more severe inhibition of cell proliferation and oxidative damage compared to gasoline exhaust particles. These findings provide novel evidence of the risk of disrupted lipid metabolism due to gasoline and diesel exhaust, emphasizing the toxicity of diesel exhaust.

show abstract

Section: Introductionmentioning

confidence: 99%