Comprehensive Study on the Reinforcement of Electrospun PHB Scaffolds with Composite Magnetic Fe<sub>3</sub>O<sub>4</sub>–rGO Fillers: Structure, Physico-Mechanical Properties, and Piezoelectric Response

Pryadko, Artyom; Mukhortova, Yulia R.; Chernozem, Roman V.; Shlapakova, Lada E.; Wagner, Dmitry V.; Romanyuk, Konstantin; Gerasimov, Evgeny Yu.; Kholkin, A. L.; Surmenev, Roman A.; Surmeneva, Maria A.

doi:10.1021/acsomega.2c05184

Cited by 12 publications

(2 citation statements)

References 90 publications

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“…The increase in the H c of all composite scaffolds is associated with a low content of magnetite particles. The particles cease to interact magnetostatically with each other; as a result, magnetite chain aggregates disrupt in the composite [ 53 ]. The value of H c facilitates a distribution of magnetic nanoparticles in the polymer fibers.…”

Section: Resultsmentioning

confidence: 99%

Effect of Fe3O4 Nanoparticles Modified by Citric and Oleic Acids on the Physicochemical and Magnetic Properties of Hybrid Electrospun P(VDF-TrFE) Scaffolds

et al. 2023

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This study considers a fabrication of magnetoactive scaffolds based on a copolymer of vinylidene fluoride and trifluoroethylene (P(VDF-TrFE)) and 5, 10, and 15 wt.% of magnetite (Fe3O4) nanoparticles modified with citric (CA) and oleic (OA) acids by solution electrospinning. The synthesized Fe3O4-CA and Fe3O4-OA nanoparticles are similar in particle size and phase composition, but differ in zeta potential values and magnetic properties. Pure P(VDF-TrFE) scaffolds as well as composites with Fe3O4-CA and Fe3O4-OA nanoparticles demonstrate beads-free 1 μm fibers. According to scanning electron (SEM) and transmission electron (TEM) microscopy, fabricated P(VDF-TrFE) scaffolds filled with CA-modified Fe3O4 nanoparticles have a more homogeneous distribution of magnetic filler due to both the high stabilization ability of CA molecules and the affinity of Fe3O4-CA nanoparticles to the solvent used and P(VDF-TrFE) functional groups. The phase composition of pure and composite scaffolds includes a predominant piezoelectric β-phase, and a γ-phase, to a lesser extent. When adding Fe3O4-CA and Fe3O4-OA nanoparticles, there was no significant decrease in the degree of crystallinity of the P(VDF-TrFE), which, on the contrary, increased up to 76% in the case of composite scaffolds loaded with 15 wt.% of the magnetic fillers. Magnetic properties, mainly saturation magnetization (Ms), are in a good agreement with the content of Fe3O4 nanoparticles and show, among the known magnetoactive PVDF or P(VDF-TrFE) scaffolds, the highest Ms value, equal to 10.0 emu/g in the case of P(VDF-TrFE) composite with 15 wt.% of Fe3O4-CA nanoparticles.

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Section: Resultsmentioning

confidence: 99%

Effect of Fe3O4 Nanoparticles Modified by Citric and Oleic Acids on the Physicochemical and Magnetic Properties of Hybrid Electrospun P(VDF-TrFE) Scaffolds

et al. 2023

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“…Moreover, it has been found that the crystallinity of an electrospun polymer directly correlates with the fiber diameter [ 73 , 74 ]. The latter can be adjusted by varying the parameters of electrospinning [ 63 ]; accordingly, crystallinity and consequently piezoelectricity also strongly depend on the electrospinning process.…”

Section: Requirements For the Design Of Piezoelectric Nerve Scaffoldsmentioning

confidence: 99%

Revealing an important role of piezoelectric polymers in nervous-tissue regeneration: A review

Shlapakova,

Surmeneva,

Kholkin

et al. 2024

Materials Today Bio

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Cell Behavior Changes and Enzymatic Biodegradation of Hybrid Electrospun Poly(3‐hydroxybutyrate)‐Based Scaffolds with an Enhanced Piezoresponse after the Addition of Reduced Graphene Oxide

Chernozem

Pariy

Surmeneva

et al. 2023

Adv Healthcare Materials

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This is the first comprehensive study of the impact of biodegradation on the structure, surface potential, mechanical and piezoelectric properties of poly(3-hydroxybutyrate) (PHB) scaffolds supplemented with reduced graphene oxide (rGO) as well as cell behavior under static and dynamic mechanical conditions. There is no effect of the rGO addition up to 1.0 wt% on the rate of enzymatic biodegradation of PHB scaffolds for 30 d. The biodegradation of scaffolds leads to the depolymerization of the amorphous phase, resulting in an increase in the degree of crystallinity. Because of more regular dipole order in the crystalline phase, surface potential of all fibers increases after the biodegradation, with a maximum (361 ± 5 mV) after the addition of 1 wt% rGO into PHB as compared to pristine PHB fibers. By contrast, PHB-0.7rGO fibers manifest the strongest effective vertical (0.59 ± 0.03 pm V −1 ) and lateral (1.06 ± 0.02 pm V −1 ) piezoresponse owing to a greater presence of electroactive 𝜷-phase. In vitro assays involving primary human fibroblasts reveal equal biocompatibility and faster cell proliferation on PHB-0.7rGO scaffolds compared to pure PHB and nonpiezoelectric polycaprolactone scaffolds. Thus, the developed biodegradable PHB-rGO scaffolds with enhanced piezoresponse are promising for tissue-engineering applications.

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Comprehensive Study on the Reinforcement of Electrospun PHB Scaffolds with Composite Magnetic Fe₃O₄–rGO Fillers: Structure, Physico-Mechanical Properties, and Piezoelectric Response

Cited by 12 publications

References 90 publications

Effect of Fe3O4 Nanoparticles Modified by Citric and Oleic Acids on the Physicochemical and Magnetic Properties of Hybrid Electrospun P(VDF-TrFE) Scaffolds

Effect of Fe3O4 Nanoparticles Modified by Citric and Oleic Acids on the Physicochemical and Magnetic Properties of Hybrid Electrospun P(VDF-TrFE) Scaffolds

Revealing an important role of piezoelectric polymers in nervous-tissue regeneration: A review

Cell Behavior Changes and Enzymatic Biodegradation of Hybrid Electrospun Poly(3‐hydroxybutyrate)‐Based Scaffolds with an Enhanced Piezoresponse after the Addition of Reduced Graphene Oxide

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Comprehensive Study on the Reinforcement of Electrospun PHB Scaffolds with Composite Magnetic Fe3O4–rGO Fillers: Structure, Physico-Mechanical Properties, and Piezoelectric Response

Cited by 12 publications

References 90 publications

Effect of Fe3O4 Nanoparticles Modified by Citric and Oleic Acids on the Physicochemical and Magnetic Properties of Hybrid Electrospun P(VDF-TrFE) Scaffolds

Effect of Fe3O4 Nanoparticles Modified by Citric and Oleic Acids on the Physicochemical and Magnetic Properties of Hybrid Electrospun P(VDF-TrFE) Scaffolds

Revealing an important role of piezoelectric polymers in nervous-tissue regeneration: A review

Cell Behavior Changes and Enzymatic Biodegradation of Hybrid Electrospun Poly(3‐hydroxybutyrate)‐Based Scaffolds with an Enhanced Piezoresponse after the Addition of Reduced Graphene Oxide

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Comprehensive Study on the Reinforcement of Electrospun PHB Scaffolds with Composite Magnetic Fe₃O₄–rGO Fillers: Structure, Physico-Mechanical Properties, and Piezoelectric Response