Comprehensive review on use of phospholipid based vesicles for phytoactive delivery

Gupta, Manish Kumar; Sansare, Vipul; Shrivastava, Birendra; Jadhav, Santosh; Gurav, Prashant

doi:10.1080/08982104.2021.1968430

Cited by 13 publications

(5 citation statements)

References 94 publications

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“…In this context, nanotechnologies can be a valuable strategy to overcome these limitations. Phospholipid vesicles are being successfully used to load plant extracts and deliver them to a number of targets via different administration routes, and several studies have demonstrated their greater therapeutic efficacy compared with conventional approaches [ 11 , 12 ]. Nanocarriers have been proved to be effective in resolving critical issues of natural compounds, such as poor bioavailability, low stability in physiological environment, low site-specific distribution, and side effects due to multi-targeting [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

A Nanotechnological Approach to Exploit and Enhance the Bioactivity of an Extract from Onopordum illyricum L. Leaves

Caddeo

Tuberoso

Floris

et al. 2023

Plants

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Plant-derived products have been used for preventive and curative purposes from the ancient era to the present day. Several studies have demonstrated the efficacy of either multicomponent-based extracts, enriched fractions, or isolated bioactives. However, they often display low solubility and bioavailability, chemical instability, poor absorption, and even toxicity, which restrict application in therapy. The use of drug delivery systems, especially nanocarriers, can overcome these physicochemical and pharmacokinetic limitations. In this study, an extract from Onopordum illyricum leaves was produced by maceration in 80% ethanol, characterized by liquid chromatography coupled to mass spectrometry, and formulated in phospholipid vesicles with the aim of exploiting and possibly enhancing its bioactivity for skin delivery. The results showed that phenolic compounds were abundantly present in the extract, especially hydroxycinnamic acid and flavonol derivatives. The extract-loaded vesicles showed small size (<100 nm), high entrapment efficiency (even >90% for most phenolic compounds), and good long-term stability. Moreover, the extract-loaded vesicles exhibited remarkable antioxidant activity, as demonstrated by colorimetric assays and by enhanced reduction of intracellular reactive oxygen species (ROS) levels in cultured skin cells. Hence, our findings support the key role of nanotechnological approaches to promote the potential of plant extracts and strengthen their application in therapy.

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Section: Introductionmentioning

confidence: 99%

A Nanotechnological Approach to Exploit and Enhance the Bioactivity of an Extract from Onopordum illyricum L. Leaves

Caddeo

Tuberoso

Floris

et al. 2023

Plants

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show abstract

“…The encapsulated drug in nanocarriers releases in controlled manner. The use of nanocarriers for controlled delivery through various routes have been investigated widely for effective management of various disease conditions (Gupta et al, 2022).…”

Section: Approaches To Design Controlled Release Systemmentioning

confidence: 99%

Gastroretentive Drug Delivery through Natural Mucilage Based Microspheres: A Concise Review

Panda,

Jirole,

Jadhav

et al. 2023

Intern. J. Zool. Invest.

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The use of novel drug delivery systems for efficient delivery of drug is recently explored area. Several novel drug delivery systems have been proved to be effective in delivery of drug. Many scientific experts have showed efficacy of novel drug delivery systems in animal models. The carrier mediated drug delivery involves use of various drug loaded carriers like nanoparticles, microparticles, microspheres, microsponge, liposomes, ethosomes, transfersomes, phytosomes and glycerosomes. The microspheres are micron sized drug loaded spherical particles. The use of natural gums and mucilage for fabrication of drug loaded microspheres is recently explored area for gastrorentive drug delivery. Thus, present review highlights use of these natural mucilage based microspheres for fabrication of drug loaded microsphere.

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“…The complex's antioxidant activity was noticeably greater than that of pure curcumin at every tested dosage level. In the second trial, isozyme of naringenin generated stronger a higher level of antioxidant activity compared to the free compound longer action's time frame, perhaps because the molecule was not being removed from the body as quickly [131]. Curcumin is a safe antioxidant and anti-inflammatory compound with a wide range of pharmacological actions that have been shown in clinical trials to be effective against a wide range of disorders.…”

Section: Curcumin Phytosomesmentioning

confidence: 99%

Progressive Journey of Phytosomes: Preparation, Characterization, Patents, Clinical trials & Commercial products

DWIVEDI,

SACHAN,

WAL

et al. 2023

jrp

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Phytosomes stand sophisticated herbal preparations that contain the phytoactive ingredients found in extracted from herbs and have the ability towards change the cell membrane's hydrophilic to lipophilic state. They may be produced as pills, creams, gels, suspensions, and other medicinal forms. Many illnesses now have a fantastic treatment alternative in phytosomes. Their therapeutic applicability may be limited by poor bioavailability and selectivity. A potential possibility for the delivery of insoluble phytochemicals has been introduced: nano-vesicles. The most commonly formulated substances are curcumin and silymarin. A variety of human and animal systems, including the cardiovascular, digestion, urination, immunological, muscle-skeletal and integumentary, pulmonary and respiratory systems, have been the subject of more than 100 studies looking at the effects of phytosomes. This list contains the quantity of articles on phytosomes and their biological functions, broken down by the system being studied. The existing method of delivering topically applied bioactive phytochemicals may be drastically altered by phytosome nanotechnology. The main problems are the inadequate penetration through biological barriers and the very low absorption rate (specifically, the skin). Phytosomes which are nanocarriers made up of lipids are essential for enhancing polyphenolic chemicals that come from herbs. A novel, patented method called phytosomes produces lipid-compatible molecular complexes by complexing standardized plant extracts or water-soluble phytoconstituents with phospholipids. This significantly increases absorption and bioavailability by increasing the hydrophilicity of a highly lipophilic drug, the phytosome or herbosome approach makes it ideal for drug administration.

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Comprehensive review on use of phospholipid based vesicles for phytoactive delivery

Cited by 13 publications

References 94 publications

A Nanotechnological Approach to Exploit and Enhance the Bioactivity of an Extract from Onopordum illyricum L. Leaves

A Nanotechnological Approach to Exploit and Enhance the Bioactivity of an Extract from Onopordum illyricum L. Leaves

Gastroretentive Drug Delivery through Natural Mucilage Based Microspheres: A Concise Review

Progressive Journey of Phytosomes: Preparation, Characterization, Patents, Clinical trials & Commercial products

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