Comprehensive review on immunopathogenesis, diagnostic and epidemiology of Senecavirus A

Houston, E. Fiona; Temeeyasen, Gun; Piñeyro, Pablo

doi:10.1016/j.virusres.2020.198038

Cited by 36 publications

(40 citation statements)

References 80 publications

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“…As previously reported, SVV nucleic acids have been detected in mice and house ies [17]; and although SVV nucleic acids were not detected in cattle, neutralizing antibodies were present [12], therefore we inferred that cattle may be infected with SVV. So far, the pig is the only host of SVV, therefore we infer that possible transmission routes of SVV, including house ies, mice, Culicoides and cattle may serve as vehicles for SVV transmission and promote the spread of SVV (Fig.…”

Section: Detection Of Svv In Mosquitoes and Culicoidessupporting

confidence: 52%

“…Since the rst report of SVV infection in pigs in 2007, porcine infection with this virus has been reported in many countries [6,12]. The clinical symptoms of porcine SVV are similar to those observed in PIVD, which includes vesicular lesions in the snout, coronary band, and hooves.…”

Section: Discussionmentioning

confidence: 88%

“…The clinical symptoms of porcine SVV are similar to those observed in PIVD, which includes vesicular lesions in the snout, coronary band, and hooves. The loss of piglets within the rst 4 days of life if infected with SVV can reach levels of 30-70%; and clinical signs such as muscular weakness, lethargy, excessive salivation, cutaneous hyperemia, neurologic manifestations, and diarrhea can manifest in neonatal pigs [8,12].…”

Section: Discussionmentioning

confidence: 99%

“…SVV-001 was the rst SVV strain to be identi ed and isolated, having been reported as a cell contaminant in USA in 2002, used as a drug to treat cancer [3,5]. In 2007, porcine infection with SVV was con rmed in Canada, followed by infection cases reported from America, Brazil, China, Columbia, Thailand and Vietnam [6][7][8][9][10][11][12]. The main clinical symptoms of SVV infection are blisters on the snout and/or hooves, which made it di cult to distinguish from food-and-mouth disease virus (FMDV), vesicular stomatitis virus (VSV), swine vesicular disease virus (SVDV), and vesicular exanthema of swine virus (VESV) [2,12].…”

Section: Introductionmentioning

confidence: 99%

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Pathogenicity of Seneca Valley virus in Pigs and Detection in Culicoides from an Infected Pig Farm

Zhang

et al. 2021

Preprint

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Background: Porcine vesicular disease is caused by the Seneca Valley virus (SVV), it is a novel Picornaviridae, which is prevalent in several countries. However, the pathogenicity of SVV on 5-6 week old pigs and the transmission routes of SVV remain unknown.Methods: This research mainly focuses on the pathogenicity of the CH-GX-01-2019 strain and the possible vector of SVV. In this study, 5-6 week old pigs infected with SVV (CH-GX-01-2019) and its clinical symptoms (including rectal temperatures and other clinical symptoms) were monitored, qRT-PCR were used to detect the viremia and virus distribution. Neutralization antibody assay was set up during this research. Mosquitoes and Culicoides were collected from pigsties after pigs challenge with SVV, and SVV detection within mosquitoes and Culicoides was done via RT-PCR.Results: The challenged pigs presented with low fevers and mild lethargy on 5-8 days post infection (dpi). The viremia lasted more than 14 days. SVV was detected in almost all tissues on the 14th day following the challenge, and it was significantly higher in the hoofs (vesicles) and lymph nodes in comparison with other tissues. Neutralizing antibodies were also detected and could persist for more than 28 days, in addition neutralizing antibody titers ranged from 1:128 to 1:512. Mosquitoes and Culicoides were collected from the pigsty environments following SVV infection. Although SVV was not detected in the mosquitoes, it was present in the Culicoides, however SVV could not be isolated from the positive Culicoides. Conclusions: Our work has enriched the knowledge relating to SVV pathogenicity and possible transmission routes, which may lay the foundation for further research into the prevention and control of this virus.

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Section: Detection Of Svv In Mosquitoes and Culicoidessupporting

confidence: 52%

Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Pathogenicity of Seneca Valley virus in Pigs and Detection in Culicoides from an Infected Pig Farm

Zhang

et al. 2021

Preprint

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“…Rupture of a fluid-filled vesicle would leave erosion on the skin, subsequently evolving to form a crust on the affected area. Some herds additionally suffer an increase in neonatal losses of 1- to 4-day-old piglets, termed ETNL ( 25 ). Other clinical signs include lethargy, lameness, anorexia and even diarrhea.…”

Section: Sva Characteristicsmentioning

confidence: 99%

A 5-Year Review of Senecavirus A in China since Its Emergence in 2015

et al. 2020

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Senecavirus A (SVA), previously known as Seneca Valley virus, is classified into the genus Senecavirus in the family Picornaviridae . This virus can cause vesicular disease and epidemic transient neonatal losses in swine. Typical clinical signs include vesicular and/or ulcerative lesions on the snout, oral mucosa, coronary bands and hooves. SVA emerged in Guangdong Province of China in 2015, and thereafter gradually spread into other provinces, autonomous regions and municipalities (P.A.M.s). Nowadays more than half of the P.A.M.s have been affected by SVA, and asymptomatic infection has occurred in some areas. The phylogenetic analysis shows that China isolates are clustered into five genetic branches, implying a fast evolutionary speed since SVA emergence in 2015. This review presented current knowledge concerning SVA infection in China, including its history, epidemiology, evolutionary characteristics, diagnostics and vaccines.

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Picornaviridae

Rodrı́guez¹,

Arzt²

2022

Veterinary Microbiology

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Comprehensive review on immunopathogenesis, diagnostic and epidemiology of Senecavirus A

Cited by 36 publications

References 80 publications

Pathogenicity of Seneca Valley virus in Pigs and Detection in Culicoides from an Infected Pig Farm

Pathogenicity of Seneca Valley virus in Pigs and Detection in Culicoides from an Infected Pig Farm

A 5-Year Review of Senecavirus A in China since Its Emergence in 2015

Picornaviridae

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