Comprehensive review on flavonoids biological activities of Erythrina plant species

Fahmy, Nouran M.; Al‐Sayed, Eman; El-Shazly, Mohamed; Singab, Abdel Nasser B.

doi:10.1016/j.indcrop.2018.06.028

Cited by 59 publications

(51 citation statements)

References 142 publications

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“…The anomeric proton of the glucose appeared doublet with J = 9.6 Hz indicating a C-glucoside flavone. Further confirmation of the structure was obtained by 13 C-APT NMR (100 MHz, CDCl 3 , δ [ppm]), a downfield shifting of C-8 at δ(C) 104.69 ppm was due to the attachment of the glucose moiety the aglycone by a CÀ C linkage. An upfield shift of the anomeric carbon of the glucose at 73.47 (C-1''), confirmed the Cglucoside flavone structure.…”

Section: Isolation and Characterization Of Vitexinmentioning

confidence: 96%

“…Members of the Erythrina are cultivated in different countries and are widely distributed in the tropical and subtropical areas of the world . However, Erythrina speciosa is a tree native to Southern America in Brazil . Several Erythrina species were reported to possess antiviral activity .…”

Section: Introductionmentioning

confidence: 99%

“…[12] However, Erythrina speciosa is a tree native to Southern America in Brazil. [13] Several Erythrina species were reported to possess antiviral activity. [14,15] Flavonoids from Fabaceae and other pants families showed potent antiviral activity against a wide spectrum of certain RNA (RSV, Pf-3, polio) and DNA (HSV-1) viruses acting to inhibit their infectivity and/or replication.…”

Section: Introductionmentioning

confidence: 99%

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Breaking Down the Barriers to a Natural Antiviral Agent: Antiviral Activity and Molecular Docking of Erythrina speciosa Extract, Fractions, and the Major Compound

Fahmy

Al‐Sayed

Moghannem

et al. 2020

Chemistry & Biodiversity

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The in vitro cytotoxic activity in Vero cells and the antiviral activity of Erythrina speciosa methanol extract, fractions, and isolated vitexin were studied. The results revealed that E. speciosa leaves ethyl acetate soluble fraction of the methanol extract (ESLE) was the most active against herpes simplex virus type 1 (HSV‐1). Bioactivity‐guided fractionation was performed on ESLE to isolate the bioactive compounds responsible for this activity. One sub‐fraction from ESLE (ESLE IV) showed the highest activity against HSV‐1 and Hepatitis A HAV‐H10 viruses. Vitexin isolated from ESLE VI exhibited a significant antiviral activity (EC50=35±2.7 and 18±3.3 μg/mL against HAV‐H10 and HSV‐1 virus, respectively), which was notably greater than the activity of the extract and the fractions. Molecular docking studies were carried out to explore the molecular interactions of vitexin with different macromolecular targets. Analysis of the in silico data together with the in vitro studies validated the antiviral activity associated with vitexin. These outcomes indicated that vitexin is a potential candidate to be utilized commendably in lead optimization for the development of antiviral agents.

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Section: Isolation and Characterization Of Vitexinmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Breaking Down the Barriers to a Natural Antiviral Agent: Antiviral Activity and Molecular Docking of Erythrina speciosa Extract, Fractions, and the Major Compound

Fahmy

Al‐Sayed

Moghannem

et al. 2020

Chemistry & Biodiversity

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“…Natural products have gained great interest as natural alternatives to substitute the traditional synthetic compounds for health purposes as their remarkable health-promoting activity and consumer preference for the cleaning labels [1, 2]. Specially, natural products even have been considered as an abundant source for drugs production, thanks to their chemical structures diversity that synthetic compounds cannot compare [3].…”

Section: Introductionmentioning

confidence: 99%

Application of a Combined Homogenate and Ultrasonic Cavitation System for the Efficient Extraction of Flavonoids from Cinnamomum camphora Leaves and Evaluation of Their Antioxidant Activity In Vitro

Liu

Kong

et al. 2019

Journal of Analytical Methods in Chemistry

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A free-of-dust pollution extraction method combined-homogenate and ultrasonic cavitation system, namely, homogenate-combined ultrasonic cavitation synergistic extraction (HUCSE), was proposed for the efficient extraction of flavonoids from Cinnamomum camphora leaves. Response surface methodology of Box–Behnken design was employed to optimize the HUCSE process, and the optimum operation conditions attained with an extraction yield of 7.95 ± 0.27 mg/g were ethanol concentration 76%, homogenate/ultrasonic time 25 min, solvent-to-solid ratio 22 mL/g, and ultrasonic power 240 W. A second-order kinetic mathematical methodology was performed to depict the behaviors of HUCSE and heat reflux extraction method. The results suggested that the developed HUCSE is an efficient and green method for the extraction of C. camphora flavonoids or other plant natural products, where the obvious higher parameters of extraction capacity at saturation, second-order extraction rate constant, and original extraction rate were obtained when compared to the heat reflux method. The antioxidant activity assays in vitro showed that the C. camphora flavonoids possessed strong antioxidant activity and are promising to be applied as a natural alternative antioxidant.

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“…and pharmacological properties. Many other works have analyzed the properties and effects of the Erythrina genus and we suggest that the reader examine subsequent pivotal reviews [6,7].…”

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confidence: 99%

Erythrina suberosa: Ethnopharmacology, Phytochemistry and Biological Activities

et al. 2019

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Plants are a great and irreplaceable source of medicines, fuel, food, energy and even cosmetics. Since prehistory, humans have learned to use plants for survival, growth and proliferation and still today it relies on natural and cultivated vegetables for food and the source of novel compounds with pharmacological activity. Not only herbs and flowers, but also trees are used. Indeed, Erythrina suberosa Roxb. is a deciduous tree of the family Fabaceae, common in Southeast Asia. In India, E. suberosa is called the “corky coral tree” or simply the “Indian coral tree”, given its peculiar red-orange flowers that can flower throughout the year and its corky irregular bark covered by prickles. It is a plant commonly used as an ornamental tree, but it also holds ethnopharmacological and socioeconomic uses. This article explored phytobiological features of E. suberosa, analysing its taxonomy, examining its traditional and common uses and investigating its bioactive components and pharmacological properties.

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Comprehensive review on flavonoids biological activities of Erythrina plant species

Cited by 59 publications

References 142 publications

Breaking Down the Barriers to a Natural Antiviral Agent: Antiviral Activity and Molecular Docking of Erythrina speciosa Extract, Fractions, and the Major Compound

Breaking Down the Barriers to a Natural Antiviral Agent: Antiviral Activity and Molecular Docking of Erythrina speciosa Extract, Fractions, and the Major Compound

Application of a Combined Homogenate and Ultrasonic Cavitation System for the Efficient Extraction of Flavonoids from Cinnamomum camphora Leaves and Evaluation of Their Antioxidant Activity In Vitro

Erythrina suberosa: Ethnopharmacology, Phytochemistry and Biological Activities

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