Comprehensive Review of γ-Glutamyl Peptides (γ-GPs) and Their Effect on Inflammation Concerning Cardiovascular Health

Guha, Snigdha; Majumder, Kaustav

doi:10.1021/acs.jafc.2c01712

Cited by 22 publications

(15 citation statements)

References 181 publications

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“…Gamma-glutamyl glutamine belongs to the class of organic compounds known as dipeptides. Gamma-glutamyl peptides play a role in various physiological functions, including anti-inflammatory and antioxidant effects [ 46 ]. However, the role of gamma-glutamyl glutamine in colorectal carcinogenesis needs further investigation.…”

Section: Discussionmentioning

confidence: 99%

A Metabolomic Signature of Obesity and Risk of Colorectal Cancer: Two Nested Case–Control Studies

Yang

Zhu

et al. 2023

Metabolites

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Obesity is a leading contributor to colorectal cancer (CRC) risk, but the metabolic mechanisms linking obesity to CRC are not fully understood. We leveraged untargeted metabolomics data from two 1:1 matched, nested case–control studies for CRC, including 223 pairs from the US Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial and 190 pairs from a prospective Chinese cohort. We explored serum metabolites related to body mass index (BMI), constructed a metabolomic signature of obesity, and examined the association between the signature and CRC risk. In total, 72 of 278 named metabolites were correlated with BMI after multiple testing corrections (p FDR < 0.05). The metabolomic signature was calculated by including 39 metabolites that were independently associated with BMI. There was a linear positive association between the signature and CRC risk in both cohorts (p for linear < 0.05). Per 1-SD increment of the signature was associated with 38% (95% CI: 9–75%) and 28% (95% CI: 2–62%) higher risks of CRC in the US and Chinese cohorts, respectively. In conclusion, we identified a metabolomic signature for obesity and demonstrated the association between the signature and CRC risk. The findings offer new insights into the underlying mechanisms of CRC, which is critical for improved CRC prevention.

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Section: Discussionmentioning

confidence: 99%

A Metabolomic Signature of Obesity and Risk of Colorectal Cancer: Two Nested Case–Control Studies

Yang

Zhu

et al. 2023

Metabolites

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“…This is similar to the concept of using negative permittivity and permeability composite materials known as metamaterials. In [9], the size of a circular polarized patch antenna was reduced by a signi cant factor 1/16 th by using complementary split-ring resonators (CSRRs) between the patch and the ground plane, with negligible reduction in the radiation characteristics of the antenna. A good discussion/summary of miniaturization techniques, especially material-based methods is presented in [10]…”

Section: Antenna Miniaturization Techniquesmentioning

confidence: 99%

Design of a Novel Miniaturization Technique for GNSS Antennas

Thankachan

2022

Preprint

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The newly added GNSS frequencies will provide better and more precise positioning services. That will improve the accuracy and precision of location tracking using mobile devices. But there are a large variety of such frequencies, due to which it is difficult for antenna designers to select the most optimum one for design. Therefore, before beginning the design of an antenna system build for positioning services, there is a need of intensive study in this field. Thus, this paper discusses in brief the different GNSS frequencies and their purpose and also summarizes types of GNSS antennas available, with focus on pros and cons of different miniaturization techniques. Finally, we propose a novel miniaturization technique which is implemented to reduce the size of dual feed stacked patch antenna for GNSS L1/L2.

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“…From the point of view of the mechanism of action, kokumi taste is associated with binding between kokumi-active molecules and calcium-sensing receptors (CaSRs), leading to its subsequent allosteric activation . Specifically, the Venus flytrap (VFT) domain of human CaSR is described as the binding site for kokumi substances, with its ability to close over ligands reported as the molecular initiating event underpinning CaSR activation and kokumi perception. , There is a high correlation between CaSR agonist activity and taste intensity .…”

Section: Introductionmentioning

confidence: 99%

Building a Kokumi Database and Machine Learning-Based Prediction: A Systematic Computational Study on Kokumi Analysis

He,

Liu,

et al. 2024

J. Chem. Inf. Model.

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Kokumi is a subtle sensation characterized by a sense of fullness, continuity, and thickness. Traditional methods of taste discovery and analysis, including those of kokumi, have been labor-intensive and costly, thus necessitating the emergence of computational methods as critical strategies in molecular taste analysis and prediction. In this study, we undertook a comprehensive analysis, prediction, and screening of the kokumi compounds. We categorized 285 kokumi compounds from a previously unreleased kokumi database into five groups based on their molecular characteristics. Moreover, we predicted kokumi/ non-kokumi and multi-flavor compositions using six structure− taste relationship models: MLP-E3FP, MLP-PLIF, MLP-RDKFP, SVM-RDKFP, RF-RDKFP, and WeaveGNN feature of Atoms and Bonds. These six predictors exhibited diverse performance levels across two different models. For kokumi/non-kokumi prediction, the WeaveGNN model showed an exceptional predictive AUC value (0.94), outperforming the other models (0.87, 0.90, 0.89, 0.92, and 0.78). For multi-flavor prediction, the MLP-E3FP model demonstrated a higher predictive AUC and MCC value (0.94 and 0.74) than the others (0.73 and 0.33; 0.92 and 0.70; 0.95 and 0.73; 0.94 and 0.64; and 0.88 and 0.69). This data highlights the model's proficiency in accurately predicting kokumi molecules. As a result, we sourced kokumi active compounds through a highthroughput screening of over 100 million molecules, further refined by toxicity and similarity screening. Lastly, we launched a web platform, KokumiPD (https://www.kokumipd.com/), offering a comprehensive kokumi database and online prediction services for users.

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Comprehensive Review of γ-Glutamyl Peptides (γ-GPs) and Their Effect on Inflammation Concerning Cardiovascular Health

Cited by 22 publications

References 181 publications

A Metabolomic Signature of Obesity and Risk of Colorectal Cancer: Two Nested Case–Control Studies

A Metabolomic Signature of Obesity and Risk of Colorectal Cancer: Two Nested Case–Control Studies

Design of a Novel Miniaturization Technique for GNSS Antennas

Building a Kokumi Database and Machine Learning-Based Prediction: A Systematic Computational Study on Kokumi Analysis

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