Comprehensive Review of Tissue Adhesives

Jenkins, Lauren E; Davis, Loretta S.

doi:10.1097/dss.0000000000001576

Cited by 17 publications

(12 citation statements)

References 37 publications

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“…The use of NBCA+MS surgical adhesive reduced the time necessary to fix the SC graft and the number of sutures used; such time reduction, especially in case of the open rhinoplasty, can reduce the risk of supra-infection due to possible staphylococcic contamination, a bacterium commonly presents on skin and nasal mucosa. 24,25 In addition, NBCA+MS has a bacteriostatic effect that persists for 1 week after its use, which could have reduced the risk to develop a post-surgical infection, which instead can be observed using other types of CA 26 ; in fact, we did not observe any statistically differences in term of infection by comparing the two groups. 27…”

Section: Discussionmentioning

confidence: 60%

A Prospective Randomized Trial of N-butyl-cyanoacrylate + Metacryloxysulfolane Adhesive versus Suture Alone for Grafting in Rhinoplasty: 9 year Follow-up

Martino

Salzano

Martino³

et al. 2020

Ann Otol Rhinol Laryngol

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Objective: Use of cyanoacrylate glue in facial plastic surgery is still controversial due to the absence of long-term follow up showing the results. Aim of our study is comparing the long-term outcomes of N-butyl-cyanoacrylate + Metacryloxysulfolane versus traditional sutures in rhinoplasty. Methods: Prospective comparative study. One hundred forty-two patients affected by ptotic nasal tip were included and randomized in two groups. In group A, the surgeon fixed the graft by using the glue and suture and in group B by using the traditional suture only. The following data were collected and compared by statistical analysis: nasolabial angle before and after surgery, dimensions of the graft, duration time (in minutes) for graft application during the surgery, number of sutures applied to fix the graft, presence of post-surgery negative outcomes. Results: All patients statistically improved their nasolabial angle after surgery (ANOVA: P < .0001) without statistically significant differences between the two groups both at short and long follow-up (χ: P = 1 and P = .9 respectively). A statistically significant difference in graft fixation time ( P < .00001) and number of sutures (t: P < .00001) used was observed between the two groups. No statistically significant difference was observed in prevalence of infection after surgery. Conclusion: N-butyl-cyanoacrylate + Metacryloxysulfolane could be a valid tool to reduce the necessary number of sutures and to reduce the time required for graft fixation graft fixation with consistent results in long-term follow-up.

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Section: Discussionmentioning

confidence: 60%

A Prospective Randomized Trial of N-butyl-cyanoacrylate + Metacryloxysulfolane Adhesive versus Suture Alone for Grafting in Rhinoplasty: 9 year Follow-up

Martino

Salzano

Martino³

et al. 2020

Ann Otol Rhinol Laryngol

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“…In addition, the closure with tissue adhesives is cosmetically similar to that achieved with standard suture closure [31]. Tissue adhesives are more expensive than suture materials, but that cost is offset by the inherent costs associated with physician time to suture, bandaging, and repeat visit for suture removal [32]. In a busy and unpredictable emergency department, this time saving is essential.…”

Section: Tissue Adhesives For Wound Closurementioning

confidence: 95%

“…Cyanoacrylate glues are monomers that react upon contact with water on tissue in an exothermic reaction, causing them to polymerize across the wound edges, allowing healing to take place below. These agents are also antimicrobial, which is an additional advantage [3,30,32].…”

Section: Polyethylene-based Tissue Adhesivesmentioning

confidence: 99%

“…Given these properties, it stands to reason that wounds most appropriate for glue repair are wounds that would require a suture strength of 5-0 or 6-0. Therefore, cyanoacrylate synthetic glues are not recommended for wounds under tension such as those crossing joint lines, highly gaping wounds, or wounds in very moist areas of the body [30,32]. It is acceptable to use tissue adhesive glue on wounds that require deep sutures to reduce tension and gaping on the wound, so long as after those sutures are placed, the wound would be appropriate for closure with 5-0 or 6-0 suture.…”

Section: Polyethylene-based Tissue Adhesivesmentioning

confidence: 99%

“…The adhesive should never be introduced into the wound. In addition to causing an exothermic reaction because of the amount of moisture, it creates a foreign body reaction, with tissue inflammation and poor healing [30,32]. Tissue adhesives should therefore not be used on heavily contaminated wounds, bites, macerated wounds, or wounds that are complex and difficult to approximate [30][31][32].…”

Section: Polyethylene-based Tissue Adhesivesmentioning

confidence: 99%

See 2 more Smart Citations

Thrombostatic Agents and Tissue Adhesives in the Emergency Department: Stopping the Bleeding, Closing the Wound, and Novel Applications

Jeanmonod¹,

Rammohan²,

Jeanmonod³

2020

Biosurgicals - The Next Frontier in Operative Approaches [Working Title]

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Complaints of bleeding are frequent presentations to the emergency department, and although most bleeding can be controlled with direct pressure, increased use of antiplatelet agents and anticoagulants complicates what might be otherwise simple bleeding. Industry has met the demand for hemostatic adjuncts, and a number of products are available for the emergency physician to assist in hemostatic control and wound closure. This chapter will cover the various available technologies, covering their preferred use and discussing particular bleeding scenarios and which technology may be best for each scenario.

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Breaking the boundaries of wound closure: A novel polyurethane tissue adhesive with enhanced healing properties

Zhou,

Shi,

Xia

et al. 2024

J Biomedical Materials Res

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Over the past few decades, there have been advancements in the development of high‐performance tissue adhesives as alternatives to traditional sutures and staples for rapid and effective wound closure post‐surgery. While tissue adhesives offer advantages such as ease of use, short application time, and minimal tissue damage, they also face challenges related to biocompatibility, biodegradability, and adhesive strength. In this study, L‐lysine diisocyanate (LDI) and trimethylolpropane (TMP) were utilized as the primary raw materials to produce a prepolymer terminated with NCO, resulting in the development of a new biocompatible polyurethane tissue adhesive (TMP‐LDI). Additionally, SiO2 nanoparticles were incorporated into the prepolymer, significantly enhancing the adhesive strength of the TMP‐LDI tissue adhesive through the “nanobridging effect,” achieving a strength of 170.4 kPa. Furthermore, the SiO2/TMP‐LDI tissue adhesive exhibited satisfactory temperature change during curing and degradation performance. In vitro and in vivo studies demonstrated that SiO2/TMP‐LDI exhibited good biocompatibility, efficient hemostasis, antimicrobial properties, and the ability to promote wound healing. This research presents a novel approach for the development of tissue adhesives with superior adhesive performance.

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Comprehensive Review of Tissue Adhesives

Abstract: Cyanoacrylates serve as a safe and effective suture alternative in appropriate dermatologic surgeries and procedures.

Cited by 17 publications

References 37 publications

A Prospective Randomized Trial of N-butyl-cyanoacrylate + Metacryloxysulfolane Adhesive versus Suture Alone for Grafting in Rhinoplasty: 9 year Follow-up

A Prospective Randomized Trial of N-butyl-cyanoacrylate + Metacryloxysulfolane Adhesive versus Suture Alone for Grafting in Rhinoplasty: 9 year Follow-up

Thrombostatic Agents and Tissue Adhesives in the Emergency Department: Stopping the Bleeding, Closing the Wound, and Novel Applications

Breaking the boundaries of wound closure: A novel polyurethane tissue adhesive with enhanced healing properties

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