Comprehensive Review of Hyperbaric Oxygen Therapy

Danesh-Sani, Seyed Amir; Sarabi, Zhaleh Shariati; Feiz, Mohammad Reza

doi:10.1097/scs.0b013e3182668777

Cited by 10 publications

(12 citation statements)

References 58 publications

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“…The optimal therapeutic protocol for patients suffering from cancers of the paranasal sinuses is still a somewhat controversial entity (20,21). Since most patients are diagnosed at advanced stages, multidisciplinary approach is preferred to treat the disease.…”

Section: Discussionmentioning

confidence: 99%

Paranasal sinuses malignancies: A 12-year review of clinical characteristics

Danesh-Sani

Sarafraz²,

Chamani³

et al. 2016

Med Oral

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BackgroundInadequate epidemiologic investigations of the paranasal sinuses malignancies prompted this retrospective study with special emphasis on a major group of 111 tumors.Material and MethodsClinical records of 111 patients with histologically confirmed malignant tumors of the paranasal sinuses were investigated retrospectively from April 2000 to January 2012. Collection of data included demographic information, clinical manifestations, treatment plans, and histopathology of the tumor.ResultsThere were 69 (62.16%) male and 42 (37.83%) female patients (male-to-female ratio of 1.6:1), with a median age of 49±12.2 years (range 21 to 88 years). A high level of occurrence was noticed in the fifth (26.3%) decade of life. The most frequent histological types were squamous cell carcinoma (43.5%) and adenoid cystic carcinoma (19%). Among clinical manifestations, nasal obstruction was the most frequent followed by diplopia, and facial swelling. Fifty three patients (47.74%) were treated with combined approach of surgery and radiation therapy.ConclusionsParanasal sinuses malignancies are rare conditions with nonspecific symptoms which make early diagnosis of the lesions more challenging. The optimal therapeutic protocol for patients suffering from these tumors is still a somewhat controversial entity and requires further studies. Key words:Paranasal sinuses, malignancy, surgery,radiotherapy.

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Section: Discussionmentioning

confidence: 99%

Paranasal sinuses malignancies: A 12-year review of clinical characteristics

Danesh-Sani

Sarafraz²,

Chamani³

et al. 2016

Med Oral

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“…For spinal cord injury, although many animal experiments had been done, there is still a lack of convincing clinical study to confirm the effect of HBOT on people. In 2 reviews of HBOT for traumatic brain injury and stroke, [17,21] the effectiveness has not fully confirmed. Yet, in a subgroup analysis, it was found that HBOT is able to decrease mortality in the group of patients with Glasgow Coma Scale of 4 to 6 or with an intracranial pressure elevation of more than 20 mm H 2 O.…”

Section: Discussionmentioning

confidence: 99%

“…The HBOT may increase blood oxygen pressure to 2000 mmHg, [17] provide enough oxygen to neurons and astrocytes, and lead to constriction in small arteries. For patients with elevated intracranial pressure (ICP), the blood flow can decrease by 20% under HBOT, which leads to more than a 30% decrease in ICP and a reduction in edema.…”

Section: Discussionmentioning

confidence: 99%

“…[10,15,16] Hyperbaric oxygen therapy (HBOT) is usually used to treat the patient with central nervous system (CNS) diseases or lesions, such as brain injury and ischaemic stroke. [17–19] Essentially, the treatment involves a tremendous increase in the oxygen partial pressure, [20] thereby supplying the ischemic tissue with oxygen and having a vaso-constrictive effect [21] on the congested artery, which reduces nervous tissue edema. In previous studies, we have performed HBOT for 10 postoperative SDAVF patients and achieved improved outcomes.…”

Section: Introductionmentioning

confidence: 99%

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Hyperbaric oxygen therapy for postoperative spinal dural arterio-venous fistula patients

Chen

Liang³

et al. 2016

Medicine

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Spinal dural arterio-venous fistula (SDAVF) is a common type of spinal vascular malformation. Surgical obliteration of the fistula can cure SDAVF anatomically, but the functional outcome is unsatisfactory.The aim of the study was to evaluate the effect of hyperbaric oxygen therapy (HBOT) on the functional recovery of postoperative SDAVF patients.This prospective cohort study included postoperative SDAVF patients. Patients were divided into control and HBOT groups. Patients in control group received conventional treatment, whereas those in the HBOT group received conventional treatment plus HBOT (2.0 atmospheric pressure absolute, 14 days). Follow-up was done at 1, 3, 6, 12, and 24 months after surgery for evaluation, including symptoms. To assess the effectiveness of HBOT on SDAVF patients, we compared the postoperative magnetic resonance imaging and neurological outcomes of each group with respect to modified Aminoff–Lougue scale and modified Denis Pain and Numbness Scale.From September 1, 2013 to January 31, 2014, 33 SDAVF patients (27 male) treated by microsurgery were included in this study. Sixteen patients were in the HBOT group and 17 patients were in the control group. At 24 months follow-up, the improvement of mDPNS for the HBOT group was significantly larger than those of the control group (2.25 vs 0.88; P = 0.005). In the HBOT group, the average length of hypersignal in magnetic resonance imaging T2 image decrease at 3 months after surgery was 3.25 compared with 2.29 in the control group (P = 0.009). No major adverse effects were reported for all 16 patients who received HBOT.The current findings suggest that HBOT is an effective and safe treatment to relieve lower body pain and numbness for postoperative SDAVF patients.

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“…Nonetheless, a portion of cancer cells located between the tumor periphery and tumor center, found in a state of low or moderate hypoxia, can survive and enter dormancy by adapting the hypoxic microenvironment. These cells become more malignant and resistant to chemotherapy and radiotherapy because the chemo or radiotherapy mainly kills or inhibits rapidly proliferating cancer cells [2]. The dormant cancer cells play an important role in cancer progression and recurrence because they are the main source for cancer metastasis and/or recurrence.…”

Section: Introductionmentioning

confidence: 99%

Synergistic Inhibitory Effect of Hyperbaric Oxygen Combined with Sorafenib on Hepatoma Cells

et al. 2014

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ObjectivesHypoxia is a common phenomenon in solid tumors, associated with chemotherapy and radiotherapy resistance, recurrence and metastasis. Hyperbaric oxygen (HBO) therapy can increase tissue oxygen pressure and content to prevent the resistance, recurrence and metastasis of cancer. Presently, Sorafenib is a first-line drug, targeted for hepatocellular carcinoma (HCC) but effective in only a small portion of patients and can induce hypoxia. The purpose of this study is to investigate the effect of HBO in combination with sorafenib on hepatoma cells.MethodsHepatoma cell lines (BEL-7402 and SK-Hep1) were treated with HBO at 2 atmosphere absolute pressure for 80 min per day or combined with sorafenib or cisplatin. At different time points, cells were tested for cell growth, colony formation, apoptosis, cell cycle and migration. Finally, miRNA from the hepatoma cells was detected by microRNA array and validated by qRT-PCR.ResultsAlthough HBO, sorafenib or cisplatin alone could inhibit growth of hepatoma cells, HBO combined with sorafenib or cisplatin resulted in much greater synergistic growth inhibition (cell proliferation and colony formation) in hepatoma cells. Similarly, the synergistic effect of HBO and sorafenib on induction of apoptosis was also observed in hepatoma cells. HBO induced G1 arrest in SK-Hep1 not in BEL-7402 cells, but enhanced cell cycle arrest induced by sorafenib in BEL-7402 treated cells. However, HBO had no obvious effect on the migration of hepatoma cells, and microRNA array analysis showed that hepatoma cells with HBO treatment had significantly different microRNA expression profiles from those with blank control.ConclusionsWe show for the first time that HBO combined with sorafenib results in synergistic growth inhibition and apoptosis in hepatoma cells, suggesting a potential application of HBO combined with sorafenib in HCC patients. Additionally, we also show that HBO significantly altered microRNA expression in hepatoma cells.

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Comprehensive Review of Hyperbaric Oxygen Therapy

Cited by 10 publications

References 58 publications

Paranasal sinuses malignancies: A 12-year review of clinical characteristics

Paranasal sinuses malignancies: A 12-year review of clinical characteristics

Hyperbaric oxygen therapy for postoperative spinal dural arterio-venous fistula patients

Synergistic Inhibitory Effect of Hyperbaric Oxygen Combined with Sorafenib on Hepatoma Cells

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