Comprehensive Review of Hybrid Collagen and Silk Fibroin for Cutaneous Wound Healing

Abstract

The use of hybridisation strategy in biomaterials technology provides a powerful synergistic effect as a functional matrix. Silk fibroin (SF) has been widely used for drug delivery, and collagen (Col) resembles the extracellular matrix (ECM). This systematic review was performed to scrutinise the outcome of hybrid Col and SF for cutaneous wound healing. This paper reviewed the progress of related research based on in vitro and in vivo studies and the influence of the physicochemical properties of the hybrid in wound healing. The results indicated the positive outcome of hybridising Col and SF for cutaneous wound healing. The hybridisation of these biomaterials exhibits an excellent moisturising property, perfectly interconnected structure, excellent water absorption and retention capacity, an acceptable range of biodegradability, and synergistic effects in cell viability. The in vitro and in vivo studies clearly showed a promising outcome in the acceleration of cutaneous wound healing using an SF and Col hybrid scaffold. The review of this study can be used to design an appropriate hybrid scaffold for cutaneous wound healing. Therefore, this systematic review recapitulated that the hybridisation of Col and SF promoted rapid cutaneous healing through immediate wound closure and reepithelisation, with no sign of adverse events. This paper concludes on the need for further investigations of the hybrid SF and Col in the future to ensure that the hybrid biomaterials are well-suited for human skin.

How to Improve Physico-Chemical Properties of Silk Fibroin Materials for Biomedical Applications?—Blending and Cross-Linking of Silk Fibroin—A Review

“…It is the main protein of the connective tissue and it is responsible for the strength of skin, tendons, cartilage tissue, and bones [ 7 ]. Silk fibroin/collagen materials as solutions, films and 3D scaffolds have been reported in the literature [ 37 , 95 , 97 , 102 , 103 , 104 , 105 ]. Miscibility of silk fibroin/collagen solutions has been studied [ 97 ].…”

Current Insight of Printability Quality Improvement Strategies in Natural-Based Bioinks for Skin Regeneration and Wound Healing

“…The main components involved to create the bioinks are biomaterials, cells, and suitable crosslinkers. Biomaterials have been invented with or without any extra modification to boost their functionality with cells in the human body [ 40 ].…”

Cellulose/Collagen Dressings for Diabetic Foot Ulcer: A Review

“…This situation occurs following the degradation of the polymer at the injury site that has been proven to stimulate the aggregation of the inflammatory cells, followed by fibroblast and epithelial cells migration [ 83 ]. Consequently, there will be rapid healing with notable wound closure at the site of the injury with the intervention of CC [ 87 , 88 ].…”