Comprehensive Review of Abdominopelvic Mesenchymal Tumors with Radiologic Pathologic Correlation and Update on Current Treatment Guidelines — Part 1

Bajaj, Gitanjali; Tirumani, Harika; Whisman, Michella K.; Raichandani, Surbhi; Ram, Roopa; Jambhekar, Kedar; Gardner, Jerad M.; Pandey, Tarun

doi:10.1053/j.sult.2020.01.002

Cited by 4 publications

(6 citation statements)

References 43 publications

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“…Contrast-enhanced CT scan is the preferred imaging study for diagnosis and staging of RPS. MRI on the other hand has superior contrast resolution and provides better tissue characterization [ 8 ]. Both CT and MRI are frequently used in clinical practice and, indeed, can provide detailed information with regard to tumor location, size, morphology, and structural changes.…”

Section: Discussionmentioning

confidence: 99%

“…In general, the CT scan features of WDLPS or non-WDLPS are typical. Most of the WDLPS consisted of predominant fatty or large-area soft tissue density masses with uniform density and integrity margins containing minimal nodular nonlipomatous component and thin septa [ 8 ]. WDLPS usually has hypovascularity or slight enhancement, without visible calcification [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

“…PMLPSs often appear as large heterogeneous masses with areas of hemorrhage and necrosis and without any visible fat, making the imaging diagnosis difficult as they look like any other sarcoma [ 19 ]. Compared to DDLPS or PMLPS, cystic/necrotic areas were less commonly observed than in WDLPS [ 8 , 16 , 18 ]. Although the CT findings demonstrated different appearances between the subtypes, there were no unique characteristics observed.…”

Section: Discussionmentioning

confidence: 99%

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Prediction of Histologic Subtype and FNCLCC Grade by SUVmax Measured on 18F-FDG PET/CT in Patients with Retroperitoneal Liposarcoma

Liu

Zhou

et al. 2021

Contrast Media & Molecular Imaging

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This study aimed to evaluate the usefulness of maximum standardized uptake value (SUVmax) on 18F-fluorodeoxyglucose positron emission tomography with computed tomography (18F-FDG PET/CT) in differentiating the subtypes and tumor grades of retroperitoneal liposarcoma (RPLS). The data of RPLS patients who underwent surgical resection from November 2013 to December 2019 at the sarcoma center of our institute were reviewed. The demographics, clinical features, and SUVmax of 84 patients who underwent preoperative 18F-FDG PET/CT scans were analyzed. Of these, 19 patients (22.6%) were with well-differentiated liposarcoma (WDLPS), 60 patients (71.4%) were with dedifferentiated liposarcoma (DDLPS), and 5 patients (6.0%) were with pleomorphic liposarcoma (PMLPS). The median SUVmax of WDLPS, DDLPS, and PMLPS groups was 2.8 (IQR: 1.9–3.2), 6.2 (IQR: 4.1–11.3), and 4.5 (IQR: 4.0–7.4). The ROC curve suggested 3.8 as an approximate cutoff value of SUVmax for distinguishing WDLPS and non-WDLPS (sensitivity = 0.769; specificity = 0.895). The median SUVmax for FNCLCC Grades 1, 2, and 3 of RPLS was 2.5 (IQR: 1.9–3.2), 4.5 (IQR: 3.2–6.7), and 9.0 (IQR: 6.0–13.3). The ROC curves suggest that SUVmax of ≤3.8 and >5.3 can be used for predicting FNCLCC Grades 1 and 3, respectively. The result showed that 18F-FDG PET/CT exhibited high sensitivity and specificity for identifying the subtypes and FNCLCC grades of RPLS. Additionally, 18F-FDG PET/CT might be a useful complementary imaging modality for guiding suitable biopsy location of RPLS.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Prediction of Histologic Subtype and FNCLCC Grade by SUVmax Measured on 18F-FDG PET/CT in Patients with Retroperitoneal Liposarcoma

Liu

Zhou

et al. 2021

Contrast Media & Molecular Imaging

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“…Atypical spindle cell tumours frequently occur in the limbs and limb girdles [ 4 ]. The posterior margins of these tumors frequently overlap the psoas muscle and retroperitoneal fat, making attaining negative margins difficult without visibility and precise dissection [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Tailored Physical Therapy in a Case of Tenotomy Post Hip Flexion Deformity With Structural Scoliosis: A Case Report

Bhagwani,

Phansopkar,

Jagzape

et al. 2024

Cureus

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Retroperitoneal tumours, mainly classified as malignant and benign, have a rare incidence. It includes major parts of the peritoneum, and surgical excision remains the optimal pathway to remove the tumour. As with any surgery, tumour resection comes with its own complications. These complications would manifest differently depending on patient adaptation or compensation for these drawbacks. Physiotherapy and its positive effects as a need after any surgical procedure become a boon when implemented as and when required. The present study describes the case of a 32-year-old woman who has complained of pain in her right hip for one year, along with forward-bending walking and difficulty sitting. The patient had a history of retroperitoneal tumour excision, after which, to compensate for the pain, she started walking by bending forward, which developed into a hip flexion deformity. The patient was managed by tenotomy and was referred to a physiotherapy outpatient (OPD) for further management. Our aim was to improve overall mobility through gait training and prevent relapses of the contracture.

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“…1 The 3-year local and distant recurrence rates of DDLPSs can be as high as 83 and 30%, respectively, 3 resulting in poor prognosis. 4,5 Surgical resection remains the only curative treatment for RLPS, and microscopically, negative margins are crucial to improve the diseasespecific survival (e.g., from a median of 18 to 103 months). 3,6 However, reaching this goal is challenging due to the difficulty in distinguishing well-differentiated tumor tissue from normal fat.…”

mentioning

confidence: 99%

Rapid and Precise Diagnosis of Retroperitoneal Liposarcoma with Deep-Learned Label-Free Molecular Microscopy

Zhou,

Liu,

Fang

et al. 2024

Anal. Chem.

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The retroperitoneal liposarcoma (RLPS) is a rare malignancy whose only curative therapy is surgical resection. However, well-differentiated liposarcomas (WDLPSs), one of its most common types, can hardly be distinguished from normal fat during operation without an effective margin assessment method, jeopardizing the prognosis severely with a high recurrence risk. Here, we combined dual label-free nonlinear optical modalities, stimulated Raman scattering (SRS) microscopy and second harmonic generation (SHG) microscopy, to image two predominant tissue biomolecules, lipids and collagen fibers, in 35 RLPSs and 34 normal fat samples collected from 35 patients. The produced dual-modal tissue images were used for RLPS diagnosis based on deep learning. Dramatically decreasing lipids and increasing collagen fibers during tumor progression were reflected. A ResNeXt101-based model achieved 94.7% overall accuracy and 0.987 mean area under the ROC curve (AUC) in differentiating among normal fat, WDLPSs, and dedifferentiated liposarcomas (DDLPSs). In particular, WDLPSs were detected with 94.1% precision and 84.6% sensitivity superior to existing methods. The ablation experiment showed that such performance was attributed to both SRS and SHG microscopies, which increased the sensitivity of recognizing WDLPS by 16.0 and 3.6%, respectively. Furthermore, we utilized this model on RLPS margins to identify the tumor infiltration. Our method holds great potential for accurate intraoperative liposarcoma detection.

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Comprehensive Review of Abdominopelvic Mesenchymal Tumors with Radiologic Pathologic Correlation and Update on Current Treatment Guidelines — Part 1

Cited by 4 publications

References 43 publications

Prediction of Histologic Subtype and FNCLCC Grade by SUVmax Measured on 18F-FDG PET/CT in Patients with Retroperitoneal Liposarcoma

Prediction of Histologic Subtype and FNCLCC Grade by SUVmax Measured on 18F-FDG PET/CT in Patients with Retroperitoneal Liposarcoma

Tailored Physical Therapy in a Case of Tenotomy Post Hip Flexion Deformity With Structural Scoliosis: A Case Report

Rapid and Precise Diagnosis of Retroperitoneal Liposarcoma with Deep-Learned Label-Free Molecular Microscopy

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