Comprehensive profiling of pre-infection antibodies identifies HIV targets associated with viremic control and viral load
Wendy Grant-McAuley,
William Morgenlander,
Sarah E. Hudelson
et al.
Abstract:BackgroundHigh HIV viral load (VL) is associated with increased transmission risk and faster disease progression. HIV controllers achieve viral suppression without antiretroviral (ARV) treatment. We evaluated viremic control in a community-randomized trial with >48,000 participants.MethodsA massively multiplexed antibody profiling system, VirScan, was used to quantify pre- and post-infection antibody reactivity to HIV peptides in 664 samples from 429 participants (13 controllers, 135 viremic non-control… Show more
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