Comprehensive profile of circRNAs in formaldehyde induced heart development

Zhang, Ying; Yang, Yanyan; Ju, Hui; He, Xiangqin; Sun, Peng; Tian, Yu; Yang, Po; Song, Xiaoxia; Yu, Tao; Jiang, Zhirong

doi:10.1016/j.fct.2022.112899

Cited by 10 publications

(3 citation statements)

References 94 publications

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“…CircRNA is usually produced by exons or introns of their sourcegenes, and the cyclization of circRNA probably affects the expression of the sourcegene [ 21 ]. We analyzed sourcegenes of 29 DE circRNAs from LQC and LFC, then KEGG and GO enrichment analysis were performed on them (Fig.…”

Section: Resultsmentioning

confidence: 99%

Expression profile and bioinformatics analysis of circRNA and its associated ceRNA networks in longissimus dorsi from Lufeng cattle and Leiqiong cattle

Yang,

Wu,

Guo

et al. 2023

BMC Genomics

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This paper aims to explore the role of circRNA expression profiles and circRNA-associated ceRNA networks in the regulation of myogenesis in the longissimus dorsi of cattle breeds surviving under subtropical conditions in southern China by RNA sequencing and bioinformatics analysis. It also aims to provide comprehensive understanding of the differences in muscle fibers in subtropical cattle breeds and to expand the knowledge of the molecular networks that regulate myogenesis. With regard to meat quality indicators, results showed that the longissimus dorsi of LQC had lower pH (P < 0.0001), lower redness (P < 0.01), lower shear force (P < 0.05), and higher brightness (P < 0.05) than the longissimus dorsi of LFC. With regard to muscle fiber characteristics, the longissimus dorsi of LQC had a smaller diameter (P < 0.0001) and higher density of muscle fibers (P < 0.05). The analysis results show that the function of many circRNA-targeted mRNAs was related to myogenesis and metabolic regulation. Furthermore, in the analysis of the function of circRNA source genes, we hypothesized that btacirc_00497 and btacirc_034497 may regulate the function and type of myofibrils by affecting the expression of MYH6, MYH7, and NEB through competitive linear splicing.

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Section: Resultsmentioning

confidence: 99%

Expression profile and bioinformatics analysis of circRNA and its associated ceRNA networks in longissimus dorsi from Lufeng cattle and Leiqiong cattle

Yang,

Wu,

Guo

et al. 2023

BMC Genomics

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“…Those alterations were potentially implicated in signal transduction mechanisms associated with the regulation of the endocrine system, inflammatory response, and cancer, indicating that formaldehyde exposure can change the expression profile of miRNAs, making them potential pathogenic drivers of formaldehyde-induced diseases. The authors suggested that this dysregulation could cause the onset and progression of heart and cardiovascular diseases by modulating the expression levels of ncRNAs [99], as it may occur in congenital heart disease (CHD), where several circRNAs may be dysregulated as shown in fetal heart rat samples exposed to formaldehyde compared to the control group [100].…”

Section: Formaldehydementioning

confidence: 99%

Epigenetic Regulation in Exposome-Induced Tumorigenesis: Emerging Roles of ncRNAs

et al. 2022

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Environmental factors, including pollutants and lifestyle, constitute a significant role in severe, chronic pathologies with an essential societal, economic burden. The measurement of all environmental exposures and assessing their correlation with effects on individual health is defined as the exposome, which interacts with our unique characteristics such as genetics, physiology, and epigenetics. Epigenetics investigates modifications in the expression of genes that do not depend on the underlying DNA sequence. Some studies have confirmed that environmental factors may promote disease in individuals or subsequent progeny through epigenetic alterations. Variations in the epigenetic machinery cause a spectrum of different disorders since these mechanisms are more sensitive to the environment than the genome, due to the inherent reversible nature of the epigenetic landscape. Several epigenetic mechanisms, including modifications in DNA (e.g., methylation), histones, and noncoding RNAs can change genome expression under the exogenous influence. Notably, the role of long noncoding RNAs in epigenetic processes has not been well explored in the context of exposome-induced tumorigenesis. In the present review, our scope is to provide relevant evidence indicating that epigenetic alterations mediate those detrimental effects caused by exposure to environmental toxicants, focusing mainly on a multi-step regulation by diverse noncoding RNAs subtypes.

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“…Considering this issue, the World Health Organization (WHO) published a recommendation for safe exposure settings, specifying that a concentration of 2 ppm should not be exposed for more than 8 hours indoors, and a concentration of 0.08 ppm should not be exposed for more than 30 minutes [5]. The World Health Organization has determined that formaldehyde is teratogenic, and the International Agency for Research on Cancer has classified it as a human carcinogen (IARC) [6][7][8]. Dizziness, fatigue, headaches, and irritation of the skin, nose, eyes, and throat have all been reported as temporary symptoms.…”

Section: Introductionmentioning

confidence: 99%

Formaldehyde Sensing Using Tapered U-Shape Plastic Optical Fiber Coated With Zinc Oxide Nanorods

et al. 2022

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Continuous exposure to formaldehyde may cause injury to the central nervous, respiratory, blood, and immunological systems. Tapered U-shape plastic optical fiber (POF) coated with zinc oxide nanorods was evaluated at wavelength of 645 nm for formaldehyde vapor sensing within a concentration range from 5% to 20%. The tapered POF with 500 µm waist diameter was prepared using chemical etching technique. Zinc oxide nanorods were synthesized using hydrothermal method and growth for 12 hours on the tapered POF. The proposed sensor exhibited a good response to formaldehyde concentration ranging from 5% to 20% with sensitivity and linearity measured to be 0.00543V/% and 98.58%, respectively. Excellent measurement stability was observed when the concentrations from 5% and above are maintain over a 600 second period. Highest difference voltage was produced by 0.0958V due to the more scattering effect of ZnO nanorods at 20% of formaldehyde concentration. This proposed sensor might be also used to detect air pollution produced not just by formaldehyde vapor, but also by other dangerous or poisonous vapors or gases.

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Comprehensive profile of circRNAs in formaldehyde induced heart development

Cited by 10 publications

References 94 publications

Expression profile and bioinformatics analysis of circRNA and its associated ceRNA networks in longissimus dorsi from Lufeng cattle and Leiqiong cattle

Expression profile and bioinformatics analysis of circRNA and its associated ceRNA networks in longissimus dorsi from Lufeng cattle and Leiqiong cattle

Epigenetic Regulation in Exposome-Induced Tumorigenesis: Emerging Roles of ncRNAs

Formaldehyde Sensing Using Tapered U-Shape Plastic Optical Fiber Coated With Zinc Oxide Nanorods

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