Comprehensive Meta-Analytical Summary on Human Papillomavirus Association With Head and Neck Cancer

Abstract

An etiological role of high risk human papillomavirus (HPV) in the development of cervical cancer has been well established. Hence, attention of researchers has been focused on the role of HPV in pathogenesis of other malignancies, such as head and neck cancers. An analysis of epidemiological data on the prevalence of HPV infection among healthy people and patients with precancerous lesions and/or cancer is an important step in understanding the role of HPV in head and neck carcinogenesis. More and more data demonstrate the impact of HPV infection on disease outcome. HPV­positive patients have been shown to have better responses to radiotherapy and better overall and disease­free survival than HPV­negative patients. This review presents data of the metaanalysis based on a large number of original studies on HPV prevalence in patients with precancerous lesions and in patients with oral, oropharyngeal and laryngeal cancers as well as findings on the impact of HPV infection on survival of these patients.

Combined Effect of HPV and Several Gene SNPs in Laryngeal Cancer

“…LSCC usually affects men over 50-60 years of age [6] and is strongly related with tobacco smoking and alcohol use [7]. Meanwhile, some infectious pathogens such as HPV may act as associated carcinogenic factors [8]. Smoking trends each year are decreasing.…”

High prevalence of human papillomavirus (HPV) in oral mucosal lesions of patients at the Ambulatory of Oral Diagnosis of the Federal University of Sergipe, Northeastern Brazil

“…For genotyping, primers pertaining to the four most common HPV genotypes associated with head and neck cancer were utilized 4 , 12 , 13 . HPV-6 was the most frequent viral type in our samples, identified in 90.9% of the genotyped HPV samples.…”

The clinical observation of human papillomavirus positive breast tumor

“…Стоит отметить, что существует ряд работ, в которых высказано предположение о том, что онкогенные свойства ВПЧ для рака молочной железы очень похожи на канцерогенез ВПЧ-ассоциированной опухоли других локализаций (шейка матки и гортань) [10,11]. Было показано, что ВПЧ-позитивные больные раком шейки матки и раком гортани имеют лучший прогноз и чувствительность к химиотерапии по сравнению с ВПЧ-негативными больными [40,41]. Кроме того, есть данные о том, что при интегрированном физическом статусе ВПЧ выживаемость больных раком шейки матки значительно хуже, чем при смешанном (как в данном случае) и ýписомальном статусе вируса [42,43].…”