2023
DOI: 10.3390/jcm12031018
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Comprehensive Management of Blood Pressure in Patients with Septic AKI

Abstract: Acute kidney injury (AKI) is one of the serious complications of sepsis in clinical practice, and is an important cause of prolonged hospitalization, death, increased medical costs, and a huge medical burden to society. The pathogenesis of AKI associated with sepsis is relatively complex and includes hemodynamic abnormalities due to inflammatory response, oxidative stress, and shock, which subsequently cause a decrease in renal perfusion pressure and eventually lead to ischemia and hypoxia in renal tissue. Act… Show more

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Cited by 4 publications
(5 citation statements)
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“…Generally, the use of vasoconstrictors to maintain a MAP over 65 mmHg has been associated with an improvement in organ dysfunction. Many studies have shown that the restoration of MAP may improve the urinary output and renal indices as well [ 39 , 40 , 41 , 42 ]. Therefore, the amelioration of MAP remains a common clinical practice in the prevention and treatment of SA-AKI [ 39 , 40 , 41 , 42 ].…”
Section: Pathogenesis Of Sa-akimentioning
confidence: 99%
See 3 more Smart Citations
“…Generally, the use of vasoconstrictors to maintain a MAP over 65 mmHg has been associated with an improvement in organ dysfunction. Many studies have shown that the restoration of MAP may improve the urinary output and renal indices as well [ 39 , 40 , 41 , 42 ]. Therefore, the amelioration of MAP remains a common clinical practice in the prevention and treatment of SA-AKI [ 39 , 40 , 41 , 42 ].…”
Section: Pathogenesis Of Sa-akimentioning
confidence: 99%
“…Many studies have shown that the restoration of MAP may improve the urinary output and renal indices as well [ 39 , 40 , 41 , 42 ]. Therefore, the amelioration of MAP remains a common clinical practice in the prevention and treatment of SA-AKI [ 39 , 40 , 41 , 42 ]. However, apart from the use of intravenous fluids and vasopressors to maintain a normal renal blood flow, the hosts’ physiological rebound mechanisms, such as the RAAS (renin angiotensin aldosterone system) and the activation of the sympathetic nervous system are also implicated.…”
Section: Pathogenesis Of Sa-akimentioning
confidence: 99%
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“…High doses of the catecholamines norepinephrine (NE) and epinephrine are typically infused to maintain adequate mean arterial pressure (MAP) and organ perfusion 4 5. However, extreme doses of catecholamines may impair microvascular perfusion to the kidneys and other organs6 7 or trigger arrhythmias 8. Rescue therapies for vasoplegia are limited to the off-label use of methylene blue or hydroxocobalamin 9.…”
Section: Introductionmentioning
confidence: 99%