Comprehensive lipid tetrad index, atherogenic index and lipid peroxidation: Surrogate markers for increased cardiovascular risk in psoriasis

S, Sunitha; Rajappa, Medha; Thappa, Devinder Mohan; Chandrashekar, Laxmisha; Munisamy, Malathi; Revathy, G.; Priyadarssini, M.

doi:10.4103/0378-6323.163734

Cited by 20 publications

(8 citation statements)

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“…As reported in other studies 29 30 , increase in LDL oxidation and peroxidation products in psoriasis cases was found to be associated with hsCRP levels. However, Balci et al 31 did not find any difference in hsCRP levels of patients with mild-to-moderate psoriasis.…”

Section: Discussionsupporting

confidence: 81%

Dyslipidaemia & oxidative stress in patients of psoriasis: Emerging cardiovascular risk factors

et al. 2017

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Background & objectives:Psoriasis is a recurrent hyper-proliferative skin disease which is often associated with free radical generation, abnormal lipid metabolism and increased inflammatory secretion that induce cardiovascular risk in these patients. The present study was intended to evaluate serum lipids, lipoprotein and oxidants-antioxidants status and to establish their relationship with atherogenic risk markers [oxidized low-density lipoprotein (oxLDL) and high-sensitivity C-reactive protein (hsCRP)] in patients with psoriasis.Methods:The study was conducted on 150 psoriasis patients and 150 age- and sex-matched healthy controls. Overnight fasting blood samples were obtained for lipids, lipoproteins, lipid oxidation and peroxidation products [oxLDL, malondialdehyde (MDA)], antioxidant enzymes [reduced glutathione (GSH) and total antioxidant status] levels and hsCRP estimations.Results:The mean levels of atherogenic lipids [total cholesterol (P<0.001), triacylglycerol (P<0.01)], lipid peroxidation products (P<0.001) and oxLDL and hsCRP (P<0.001) levels in patients with psoriasis were found to be significantly higher than those of healthy controls. On the other hand, ferric-reducing ability of plasma (FRAP, P<0.001) and antioxidant enzyme activities (reduced GSH, P<0.01) were significantly lower when compared to healthy controls. The plasma oxLDL was positively correlated to LDL cholesterol (P<0.001) and MDA (P<0.001) and negatively associated with antioxidant status in these patients. Serum MDA, FRAP and oxLDL were correlated with risk of atherosclerosis in the patients with psoriasis; however, no significant association was found between reduced GSH and hsCRP.Interpretation & conclusions:The study results suggest that LDL oxidation and reactive oxygen species in addition to inflammatory markers may play a pivotal role in inducing atherosclerosis in patients of psoriasis.

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Section: Discussionsupporting

confidence: 81%

Dyslipidaemia & oxidative stress in patients of psoriasis: Emerging cardiovascular risk factors

et al. 2017

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“…HLA-C*06 allele was found to be positively associated with susceptibility to psoriasis, female gender and early onset of psoriasis in south Indian Tamil population 14 . We also observed psoriasis to be associated with significantly lowered 25-hydroxy vitamin D levels and increased levels of ischaemia-modified albumin correlating with disease severity suggesting increased systemic inflammation and oxidative stress in psoriasis 15 . Comprehensive lipid tetrad index, atherogenic index and lipid peroxidation have been reported to be surrogate markers for increased cardiovascular risk in psoriasis 16 .…”

supporting

confidence: 53%

“…Current research on psoriasis in India focuses on identifying human leukocyte antigen (HLA) associations and genetic polymorphisms conferring psoriatic risk amongst Indians and metabolic syndrome and cardiovascular risk amongst psoriatics 5 6 7 8 9 10 11 12 13 14 15 16 . We have recently reported that Th2 cytokine/regulatory T-cell gene polymorphism - interleukin-10 (IL-10) (rs1800871) polymorphism 10 , Th1/Th17 cytokine polymorphisms - IL-12B (rs3212227) and IL-23R (rs2201841) polymorphisms 11 , tumour necrosis factor alpha (TNF a) polymorphisms - TNFAIP3 (rs610604) and TNIP1 (rs17728338) polymorphisms 12 confer increased risk of psoriasis, whereas Th-2 cytokine/regulatory T-cell gene polymorphism - IL-4 (rs2243250) polymorphism 11 is protective against psoriasis in south Indian Tamil speaking population.…”

mentioning

confidence: 99%

Research on psoriasis in India: Where do we stand?

Thappa¹,

Munisamy²

2017

Indian J Med Res

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“…A number of studies have demonstrated a higher prevalence of dyslipidemia in patients with psoriasis [ 9 , 10 , 43 , 105 , 106 , 107 ]. Patients with psoriasis have been found to have increased risk of hypercholesterolemia [ 108 , 109 , 110 ]. In addition, a number of studies have shown that psoriasis is associated with decreased high-density lipoprotein (HDL) level and increased low-density lipoprotein (LDL) level [ 107 , 110 , 111 , 112 ].…”

Section: Psoriasis and Cardiovascular Risk Factorsmentioning

confidence: 99%

Psoriasis and Cardiovascular Comorbidities: Focusing on Severe Vascular Events, Cardiovascular Risk Factors and Implications for Treatment

Lan

2017

IJMS

147

121

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Psoriasis is a common and chronic inflammatory disease of the skin. It may impair the physical and psychosocial function of patients and lead to decreased quality of life. Traditionally, psoriasis has been regarded as a disease affecting only the skin and joints. More recently, studies have shown that psoriasis is a systemic inflammatory disorder which can be associated with various comorbidities. In particular, psoriasis is associated with an increased risk of developing severe vascular events such as myocardial infarction and stroke. In addition, the prevalence rates of cardiovascular risk factors are increased, including hypertension, diabetes mellitus, dyslipidemia, obesity, and metabolic syndrome. Consequently, mortality rates have been found to be increased and life expectancy decreased in patients with psoriasis, as compared to the general population. Various studies have also shown that systemic treatments for psoriasis, including methotrexate and tumor necrosis factor-α inhibitors, may significantly decrease cardiovascular risk. Mechanistically, the presence of common inflammatory pathways, secretion of adipokines, insulin resistance, angiogenesis, oxidative stress, microparticles, and hypercoagulability may explain the association between psoriasis and cardiometabolic disorders. In this article, we review the evidence regarding the association between psoriasis and cardiovascular comorbidities, focusing on severe vascular events, cardiovascular risk factors and implications for treatment.

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Comprehensive lipid tetrad index, atherogenic index and lipid peroxidation: Surrogate markers for increased cardiovascular risk in psoriasis

Abstract: Our results indicate that psoriasis, especially the severe variants, are associated with increased oxidative stress and dyslipidemia, which correlate positively with atherogenic index and hence, an increased cardiovascular risk.

Cited by 20 publications

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Dyslipidaemia & oxidative stress in patients of psoriasis: Emerging cardiovascular risk factors

Dyslipidaemia & oxidative stress in patients of psoriasis: Emerging cardiovascular risk factors

Research on psoriasis in India: Where do we stand?

Psoriasis and Cardiovascular Comorbidities: Focusing on Severe Vascular Events, Cardiovascular Risk Factors and Implications for Treatment

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