Comprehensive investigation of persistent and mobile chemicals and per- and polyfluoroalkyl substances in urine of flemish adolescents using a suspect screening approach

Kim, Da-Hye; Jeong, Yunsun; Belova, Lidia; Roggeman, Maarten; Fernández, Sandra F.; Poma, Giulia; Rémy, Sylvie; Verheyen, Veerle J.; Schoeters, Greet; Nuijs, Alexander L.N. van

doi:10.1016/j.envpol.2022.119972

Cited by 7 publications

(2 citation statements)

References 88 publications

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“…On the other hand, Zheng et al [82] also detected TFA in human serum that was in good agreement with the values reported by Duan et al [77]. Kim et al have recently reported what they believe to be the first study detecting TFA in urine samples taken from the general population [83]. Later, Zheng et al [82] reported the detection of TFA in 31% of urine samples taken, with some of the samples showing high concentrations.…”

Section: Toxicitysupporting

confidence: 80%

“…Later, Zheng et al [82] reported the detection of TFA in 31% of urine samples taken, with some of the samples showing high concentrations. However, it has also been suggested that urine may not be a suitable matrix for long-term screening [83]. Overall, there is a clear need for development of a quantitative biomonitoring strategy for emerging contaminants such as TFA and further studies are urgently required.…”

Section: Toxicitymentioning

confidence: 99%

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Trifluoroacetic Acid: Toxicity, Sources, Sinks and Future Prospects

Garavagno,

Holland,

Khan

et al. 2024

Sustainability

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Trifluoroacetic acid (TFA) is a known and persistent pollutant in the environment. Although several direct anthropogenic sources exist, production from the atmospheric degradation of fluorocarbons such as some hydrofluorocarbons (HFCs) has been a known source for some time. The current transition from HFCs to HFOs (hydrofluoroolefins) is beneficial from a global warming viewpoint because HFOs are much shorter-lived and pose a much smaller threat in terms of warming, but the fraction of HFOs converted into TFA is higher than seen for the corresponding HFCs and the region in which TFA is produced is close to the source. Therefore, it is timely to review the role of TFA in the Earth’s environment. This review considers its toxicity, sources and removal processes, measurement in a variety of environments, and future prospects. New global model integrations are used to quantify the impacts of uncertainties on TFA levels using the Henry’s Law constant for TFA and the range of gas-phase kinetic parameters chosen for the reaction of OH radicals with a representative HFO (HFO-1234yf). Model runs suggest that TFA surface concentrations vary by up to 10% based on Henry’s Law data but could be up to 25% smaller than previously modelled values suggest depending on the kinetic analysis adopted. Therefore, future estimates of TFA surface concentrations based on HFO removal require updating and the kinetic analysis of TFA production warrants further investigation. The toxicity of TFA appears to be low, but further studies of a much wider range of animal and plant types are required.

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