Comprehensive imaging of residual/recurrent nasopharyngeal carcinoma using whole-body MRI at 3 T compared with FDG-PET-CT

Ng, Shu‐Hang; Chan, Sheng-Chieh; Yen, Tzu-Chen; Liao, Chun‐Ta; Chang, Joseph Tung-Chieh; Ko, Sheung‐Fat; Wang, Hung‐Ming; Lin, Chih‐Lang; Chang, Kai-Ping; Lin, Yu-Chun

doi:10.1007/s00330-010-1784-9

Cited by 78 publications

(86 citation statements)

References 41 publications

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“…In recent years, PET scans and PET-CT scans also have been described as prognostic tools in NPC. [33][34][35] Chan et al reported a positive correlation between metabolic parameters in PET-CT and T-classification at diagnosis. 33 Gordin et al demonstrated a better diagnostic performance with PET-CT scans compared with stand-alone PET scans or conventional diagnostic imaging studies.…”

Section: Discussionmentioning

confidence: 99%

Multimodal treatment, including interferon beta, of nasopharyngeal carcinoma in children and young adults

Buehrlen

Zwaan

Granzen

et al. 2012

Cancer

109

150

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BACKGROUND:The authors report preliminary results from a prospective multicenter study (Nasopharyngeal Carcinoma [NPC] 2003 German Society of Pediatric Oncology and Hematology/German Children's Oncology Group [NPC‐2003‐GPOH/DCOG]).METHODS:From 2003 to 2010, 45 patients (ages 8‐20 years), including 1 patient with stage II NPC and 44 patients with stage III/IV NPC, were recruited to the study. The patient with stage II disease received radiotherapy (59.4 grays [Gy]). The patients with stage III/IV disease received 3 courses of neoadjuvant chemotherapy with cisplatin, 5‐fluorouracil, and folinic acid. The cumulative irradiation dose was 54 Gy in 5 patients, who achieved complete remission after neoadjuvant chemotherapy, and 59.4 Gy in the remaining 40 patients. All patients received concomitant cisplatin during the first week and last week of irradiation. After irradiation, all patients received interferon beta for 6 months. Tumor response was evaluated by magnetic resonance imaging studies and positron emission tomography scans.RESULTS:After the completion of treatment, 43 of 45 patients were in complete remission. In 2 patients, only a partial response was achieved, followed by distant metastases (1 patient) or local progression and distant metastases (1 patient), 6 months and 10 months after diagnosis, respectively. Another patient developed a solitary pelvic bone metastasis 21 months after diagnosis. After a median follow‐up of 30 months (range, 6‐95 months), the event‐free survival rate was 92.4%, and the overall survival was 97.1%. Acute toxicity consisted mainly of leucopenia, mucositis, and nausea; and late toxicity consisted of hearing loss and hypothyroidism.CONCLUSIONS:Combined therapy with neoadjuvant chemotherapy, radiochemotherapy, and interferon beta was well tolerated and resulted in a very good outcome that was superior to the outcomes of published results from all other pediatric NPC study groups. Cancer 2012. © 2012 American Cancer Society.

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Section: Discussionmentioning

confidence: 99%

Multimodal treatment, including interferon beta, of nasopharyngeal carcinoma in children and young adults

Buehrlen

Zwaan

Granzen

et al. 2012

Cancer

109

150

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“…The acceptable interval between PET/CT or PET and the reference standard (item 4) was not presented in 91% of the articles (5,14,15,(17)(18)(19)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35). The common weaknesses were concentrated in the masking between the reference standard and index test (items 10 and 11).…”

Section: Assessment Of Study Quality and Publication Biasmentioning

confidence: 99%

¹⁸F-FDG PET/CT for the Diagnosis of Residual or Recurrent Nasopharyngeal Carcinoma After Radiotherapy: A Metaanalysis

et al. 2015

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The aim of this work was to assess the overall value of 18 F-FDG PET/ CT in the diagnosis of residual or recurrent nasopharyngeal carcinoma using a metaanalysis. Methods: The literature published between January 1990 and September 2014 was searched in the PubMed, EMBASE, Cochrane Library, EBSCO, VIP, CNKI, and Wanfang databases to identify eligible studies on PET/CT of residual or recurrent lesions. The methodologic quality of the included studies was evaluated using the "quality assessment for studies of diagnostic accuracy" tool. Summary sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio, and receiver-operating characteristic curve were obtained using Meta-DiSc freeware. Subgroups were also analyzed. Results: A total of 23 studies, involving 1,253 subjects, were included in the metaanalysis. Pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio, with 95% confidence intervals in parentheses, for 18 F-FDG PET or PET/CT were 0.93 (0.91-0.95), 0.87 (0.84-0.89), 5.52 (3.96-7.71), 0.12 (0.09-0.15), and 55.31 (34.94-87.57), respectively. The area under the receiver-operating characteristic curve and Q* index estimate of PET/CT were 0.9473 and 0.8869, respectively. There was no significant difference between the area under the curve of PET and PET/CT (P . 0.05). Conclusion: Our study has confirmed that 18 F-FDG PET/ CT has high sensitivity and specificity but significant heterogeneity in the diagnosis of residual or recurrent nasopharyngeal carcinoma.

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“…10,11,13 There are still two studies in which 18 FDG PET-CT have the same sensitivity with gadolinium-enhanced MRI (0.89 vs 0.89 and 1.00 vs 1.00). 8,12 Our meta-analysis showed that gadolinium-enhanced MRI tended to have higher sensitivity (0.91 vs 0.84) than 18 FDG PET-CT. In the 10 included studies, 18 FDG PET-CT has similar specificity with gadolinium-enhanced MRI.…”

Section: Discussionmentioning

confidence: 83%

“…In two 15,20 of 10 articles, the study design was retrospective. In two studies (357 patients), 7,8 only patients with lung cancer were enrolled, in another two studies (102 patients), 10,19 only patients with colorectal cancer were enrolled, in four studies (511 patients), 9,12,13,18 only patients with head and neck cancer were enrolled, and in two studies (135 patients), 1,11 mixed patient populations were enrolled.…”

Section: Study Selection and Descriptionmentioning

confidence: 99%

“…1,[7][8][9] Several studies have demonstrated the diagnostic properties of 18 FDG PET-CT and the detection of liver metastatic cancers. [10][11][12][13] However, the differences in the efficacy between 18 FDG PET-CT and gadolinium-enhanced MRI for the detection of liver metastatic cancers have not been clearly delineated. Here, we undertook a meta-analysis of all available studies to compare the diagnostic performance of 18 FDG PET-CT and gadolinium-enhanced MRI in evaluating liver metastatic cancers.…”

Section: Introductionmentioning

confidence: 99%

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Meta‐analysis of diagnosis of liver metastatic cancers: Comparison of ¹⁸FDG PET‐CT and gadolinium‐enhanced MRI

2014

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Comprehensive imaging of residual/recurrent nasopharyngeal carcinoma using whole-body MRI at 3 T compared with FDG-PET-CT

Cited by 78 publications

References 41 publications

Multimodal treatment, including interferon beta, of nasopharyngeal carcinoma in children and young adults

Multimodal treatment, including interferon beta, of nasopharyngeal carcinoma in children and young adults

¹⁸F-FDG PET/CT for the Diagnosis of Residual or Recurrent Nasopharyngeal Carcinoma After Radiotherapy: A Metaanalysis

Meta‐analysis of diagnosis of liver metastatic cancers: Comparison of ¹⁸FDG PET‐CT and gadolinium‐enhanced MRI

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Comprehensive imaging of residual/recurrent nasopharyngeal carcinoma using whole-body MRI at 3 T compared with FDG-PET-CT

Cited by 78 publications

References 41 publications

Multimodal treatment, including interferon beta, of nasopharyngeal carcinoma in children and young adults

Multimodal treatment, including interferon beta, of nasopharyngeal carcinoma in children and young adults

18F-FDG PET/CT for the Diagnosis of Residual or Recurrent Nasopharyngeal Carcinoma After Radiotherapy: A Metaanalysis

Meta‐analysis of diagnosis of liver metastatic cancers: Comparison of 18FDG PET‐CT and gadolinium‐enhanced MRI

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¹⁸F-FDG PET/CT for the Diagnosis of Residual or Recurrent Nasopharyngeal Carcinoma After Radiotherapy: A Metaanalysis

Meta‐analysis of diagnosis of liver metastatic cancers: Comparison of ¹⁸FDG PET‐CT and gadolinium‐enhanced MRI