Comprehensive Identification of Glycosphingolipids in Human Plasma using Hydrophilic Interaction Liquid Chromatography – Electrospray Ionization Mass Spectrometry
Abstract:Glycosphingolipids (GSL) represent a highly heterogeneous class of lipids with many cellular functions, implicated in a wide spectrum of human diseases. Their isolation, detection, and comprehensive structural analysis is a challenging task due to the structural diversity of GSL molecules. In this work, GSL subclasses are isolated from human plasma using an optimized monophasic ethanol–water solvent system capable to recover a broad range of GSL species. Obtained deproteinized plasma is subsequently … Show more
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