Comprehensive Health Status Assessment of Centenarians: Results From the 1999 Large Health Survey of Veteran Enrollees

Selim, Alfredo J.; Fincke, Graeme; Berlowitz, Dan R.; Miller, Donald R.; Qian, Shirley; Lee, Austin; Cong, Zhongxiao; Rogers, William H.; Selim, Bernardo J.; Ren, Xinhua S.; Spiro, Avron; Kazis, Lewis E.

doi:10.1093/gerona/60.4.515

Cited by 47 publications

(31 citation statements)

References 17 publications

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“…Poon and colleagues (1992) discovered that the common characteristics of the members of the Georgia centenarians sample were optimism and flexibility, which are associated with psychological resilience (Riolli et al, 2002). Selim and colleagues (2005) reported that U.S. centenarian veterans were psychologically resilient despite poor physical health. Jopp and Rott (2006) also demonstrated that psychological resilience was well preserved at the very end of the life span in the Heidelberg Centenarian Study.…”

Section: Phenotypic Health Characteristicsmentioning

confidence: 99%

Demographics, phenotypic health characteristics and genetic analysis of centenarians in China

Zeng

Feng

et al. 2017

Mechanisms of Ageing and Development

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After a brief introduction to the background, significance and unique features of the centenarian population in China, we describe the Chinese Longitudinal Healthy Longevity Study (CLHLS), which is the world’s largest study of centenarians, nonagenarians, octogenarians, and compatible young-old aged 65–79. Based on the CLHLS data and other relevant studies, we summarize demographic and socioeconomic characteristics as well as self-reported and objectively-tested health indicators of centenarians in China, with an emphasis on gender differences and rural/urban disparities. We then compare five-year-age-specific trajectories of physical and cognitive functions, self-reported health, and life satisfactions from ages 65–69 to 100+, concluding that good psychological resilience and optimism are keys to the exceptional longevity enjoyed by centenarians. We discuss recent findings of novel loci and pathways that are significantly associated with longevity based on the genome-wide association study (GWAS) of the CLHLS centenarian sample, which is 2.7 times as large as prior GWAS of longevity. We also highlight colleagues’ and our own studies on longevity candidate genes and gene-environment interaction analyses. Finally, we discuss limitations inherent in our studies of centenarians in China and further research perspectives.

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Section: Phenotypic Health Characteristicsmentioning

confidence: 99%

Demographics, phenotypic health characteristics and genetic analysis of centenarians in China

Zeng

Feng

et al. 2017

Mechanisms of Ageing and Development

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“…To date, there are many studies which focus on the healthy status of centenarians, but most of them focused in a specific area of gerontological epidemiology, such as mental [8], cognitive [9,10], clinical [6,11], and physical [6,12] epidemiology. Very few studies actually investigate the trace element nutrition status of centenarians.…”

Section: Introductionmentioning

confidence: 99%

Trace Elements in Fingernails of Healthy Chinese Centenarians

Zou

et al. 2011

Biol Trace Elem Res

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Trace element concentrations in body tissues of healthy centenarians have not been widely analyzed, yet they can be used as reference data leading to improved assessment of the aging process and monitoring of the micronutrient status of this age group. The present study sought to assess trace element concentrations and behaviors in the fingernails of healthy Chinese centenarians. The effects of gender on element concentrations, which also play an important role in determining the lifespan, were also investigated. Trace elements (Ba, Cd, Co, Cr, Cu, Fe, Li, Mn, Mo, Ni, Pb, Se, Sr, and Zn) in the fingernails of 78 healthy Chinese centenarians were determined by inductively coupled plasma mass spectrometry. The overall reference values obtained in milligram per kilogram are as follows: Ba, 5.10; Cd, 0.031; Co, 0.101; Cr, 0.82; Cu, 3.71; Fe, 154.35; Li, 0.31; Mn, 3.09; Mo, 0.040; Ni, 0.95; Pb, 1.86; Se, 0.44; Sr, 6.20; and Zn, 147.96. Data analysis showed that only Cr and Se concentrations show a normal distribution, and no significant difference between male and female groups was found for any element except Cr. Result also revealed that sufficient Se, Co, and Zn as well as lower or lack of exposure to Cr contribute positively to the lifespan of centenarians. The results suggest that regulating in vivo contents of trace elements, especially Se, Co, and Zn, is reasonable to intervene with geriatric diseases.

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“…Knowledge of critical factors affecting everyday functioning can permit development of effective interventions which capitalize on or enhance retained abilities, facilitating recovery, maintenance, or improvement of functional capacity (e.g., Fortinsky, Covinsky, Palmer, & Landefeld, 1999). Earlier research with centenarians has often been limited to small sample sizes or subsets of the population such as those with intact cognition or male veterans (e.g., Evert et al, 2003; Gondo et al, 2006; Holtsberg et al, 1995; Selim et al, 2005; Silver et al, 2001). Consequently, we present normative data for cognitive and physical performance measures gathered in the Georgia Centenarian Study in order to expand the age groups for which norms on neuropsychological test scores, functional abilities, and disease comorbidities are available.…”

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confidence: 99%

Cognitive Function, Physical Performance, Health, and Disease: Norms From the Georgia Centenarian Study

Davey

Elias

Siegler

et al. 2010

Experimental Aging Research

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This study provides, for the first time, normative data on cognitive functioning and physical performance, health and health behaviors, and diseases from a population-based sample of 244 centenarians and near-centenarians (M age = 100.5 years, range 98-108, 84.8% women, 21.3% African American) from the Georgia Centenarian Study. Data are presented by the four key dimensions of gender, race, residence, and educational attainment. Results illustrate the profound range of functioning in this age group and indicate considerable differences as a function of each dimension. Bivariate models generally suggest that cognitive functioning and physical performance is higher for: men than women; whites than African Americans; community than facility residents; those with more than high school education than those with less than high school education. Multivariate models elaborate that differences in educational attainment generally account for the largest proportion of variance in cognitive functioning and residential status generally accounts for the largest proportion of variance in physical performance measures. Addition of health variables seldom increases variance accounted for in each domain beyond these four dimensions.Centenarians provide an excellent model for aging by virtue of the fact that they have come very close to reaching the maximum lifespan. They afford an opportunity to examine questions about both normal and pathological components of aging and longevity. Although they represent an ever growing proportion of the older adult population, centenarians remain NIH Public Access Author ManuscriptExp Aging Res. Author manuscript; available in PMC 2011 October 1. NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript extremely rare. Most publicly available data resources on aging include data from few, if any, centenarians. Even fewer provide information across a wide range of content areas including physical and functional capacity, cognition, and diseases.Exceptional longevity is a heterogeneous phenotype. Sebatiani and colleagues (2010) recently reported that even the genetics of exceptional longevity are complex. Their genome wide association scan identified 150 single nucleotide polymorphisms (SNPs) which were more common in centenarians than controls. These SNPs could be further clustered into 19 different genotypes. These genotypes, in turn, had different associations with age at death, likelihood of age-associated diseases, and age of disease onset.To date, we know very little about the extent of heterogeneity in cognitive function, physical performance, health and health behaviors, and diseases among centenarians, particularly in the population-based context and differences across major demographic variables such as gender, race, residential status, and educational attainment. Two previous papers in Experimental Aging Research have included extensive normative data on neuropsychological test performance with stratification by multiple age groups and education (Dore et al.,...

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Comprehensive Health Status Assessment of Centenarians: Results From the 1999 Large Health Survey of Veteran Enrollees

Cited by 47 publications

References 17 publications

Demographics, phenotypic health characteristics and genetic analysis of centenarians in China

Demographics, phenotypic health characteristics and genetic analysis of centenarians in China

Trace Elements in Fingernails of Healthy Chinese Centenarians

Cognitive Function, Physical Performance, Health, and Disease: Norms From the Georgia Centenarian Study

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