Comprehensive geriatric assessment of elderly highlanders in Qinghai, China, III: Oxidative stress and aging in Tibetan and Han elderly highlanders

Sakamoto, Ryota; Kimura, Yumi; Ishine, Masayuki; Kosaka, Yasuyuki; Wada, Taizo; Wada, Christopher A.; Nakatsuka, Masahiro; Ishimoto, Yasuko; Hirosaki, Mayumi; Kasahara, Yoriko; Konno, Akiko; Chen, Wingling; Fujisawa, Michiko; Otsuka, Kuniaki; Nakashima, Michiro; Wang, Hongxin; Dai, Qi; Yang, Aixia; Qiao, Haisheng; Gao, Jidong; Li, Zhanquan; Zhang, Yongshou; Ge, Ri Li; Okumiya, Kiyohito

doi:10.1111/j.1447-0594.2009.00544.x

Cited by 11 publications

(11 citation statements)

References 39 publications

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“…33 However, as social globalism including prolongation of lifespan is reaching highland areas and lifestyle at high altitudes are changing from traditional to modern, we should pay more attention to tendency of metabolic syndrome in the elderly highlander as we also described in another paper of this series. 34 Future study may be needed on the relationship between genetically different adaptability to oxidative stress, 35 hypoxia and human ageing phenomena including metabolic syndrome. In conclusion, Tibetan elderly highlanders were more disabled in ADL, but had higher QOL than Han elderly in Qinghai Plateau.…”

Section: Resultsmentioning

confidence: 99%

Comprehensive geriatric assessment of elderly highlanders in Qinghai, China I: Activities of daily living, quality of life and metabolic syndrome

Kimura

Sakamoto

Wada

et al. 2009

Geriatrics Gerontology Int

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Section: Resultsmentioning

confidence: 99%

Comprehensive geriatric assessment of elderly highlanders in Qinghai, China I: Activities of daily living, quality of life and metabolic syndrome

Kimura

Sakamoto

Wada

et al. 2009

Geriatrics Gerontology Int

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“…glutathione (GSH)] and it plays an important role in the prevention of oxidative stress. Oxidative stress is involved in the pathogenesis of hypertension, atherosclerosis, diabetes, osteoporosis, and cancer2 ) . It is also known to cause and accelerate the aging process3 ) .…”

Section: Introductionmentioning

confidence: 99%

Tai Chi Improves Oxidative Stress Response and DNA Damage/Repair in Young Sedentary Females

et al. 2014

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[Purpose] This study was to examine the effects of 12 weeks of Tai Chi (TC) exercise on antioxidant capacity, and DNA damage/repair in young females who did not perform regular physical exercise. [Subjects and Methods] Ten female students from a Chinese university voluntarily participated in this program. All of them practiced the 24-form simplified Tai Chi, 5 times weekly, for 12 weeks. Plasma levels of superoxide dismutase (SOD), glutathione peroxidase (GPx), malondialdehyde (MDA), glutathione (GSH), hydroxyl radical inhibiting capacity (OH·-IC), 8-hydroxy-2’-deoxyguanosine (8-OHdG), and 8-oxoguanine DNA glycosylase (OGG1) were measured at 0, 8, and 12 weeks. Heart rate (HR) was monitored during the last set of the training session at 4, 8, and 12 weeks. [Results] Plasma SOD and OH·-IC levels were increased at 8 and 12 weeks compared to the baseline (0 weeks). Gpx and GSH levels did not change significantly throughout the study period. The plasma MDA level was decreased significantly at 8 weeks but not at 12 weeks compared to the baseline value. While the plasma 8-OHdG level did not change throughout the study period, the plasma OGG1 level was significantly increased at 8 and 12 weeks compared to the baseline value. [Conclusion] TC practice for 12 weeks efficiently improved the oxidative stress response in young females who did not perform regular physical exercise. The TC exercise also increased the DNA repairing capacity.

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“…The relationship between reactive oxygen species (ROS) and geriatric dependency were examined among 235 > 60 yr old subjects (146 Hans and 89 Tibetans) (Sakamoto et al, 2009). ROS was measured using the commercially available spectrophotometric diacron-reactive oxygen metabolites test (d-ROM) which determines overall oxidative stress, by measuring total hydroperoxides.…”

Section: Oxidative Stress In Elderly Tibetan and Han Highlandersmentioning

confidence: 99%

Sightings edited by John W. Severinghaus

2010

High Altitude Medicine & Biology

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Comprehensive geriatric assessment of elderly highlanders in Qinghai, China, III: Oxidative stress and aging in Tibetan and Han elderly highlanders

Abstract: The findings of this study imply the possibility that ROS is higher among Tibetan elderly highlanders than that of Han, which related to the geriatric items. Further studies are needed to show the impact of oxidative stress on the aging of highlanders.

Cited by 11 publications

References 39 publications

Comprehensive geriatric assessment of elderly highlanders in Qinghai, China I: Activities of daily living, quality of life and metabolic syndrome

Comprehensive geriatric assessment of elderly highlanders in Qinghai, China I: Activities of daily living, quality of life and metabolic syndrome

Tai Chi Improves Oxidative Stress Response and DNA Damage/Repair in Young Sedentary Females

Sightings edited by John W. Severinghaus

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