Comprehensive genetic study of fatty acids helps explain the role of noncoding inflammatory bowel disease associated SNPs and fatty acid metabolism in disease pathogenesis

Jezernik, Gregor; Potočnik, Uroš

doi:10.1016/j.plefa.2018.02.002

Cited by 9 publications

(9 citation statements)

References 63 publications

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“…European, African American/Afro-Caribbean, East Asian, Hispanic/Latin American [139,166] Since n-3 PUFA are considered as anti-inflammatory substances, altered PUFA metabolism facilitates the chronic inflammation observed in Crohn's disease (CD). Data from the genome-wide association study point to a few SNP in FADS genes associated with CD risk [167,168]. Analysis of D6D in mesenteric adipose tissue biopsies (abnormal mesenteric adipose tissue is the hallmark of CD) shows a lower level of D6D in CD specimens than in normal tissue at both mRNA and protein level [169].…”

Section: Role Of Unsaturated Fatty Acid Desaturases In Humans and Othmentioning

confidence: 99%

“…Lack of consistency across studies may be explained by the presence of gene-diet interactions. For example, patients with specific FADS variants associated with higher endogenous production of n-6 PUFA have a greater risk of developing CD even with lower dietary intake of n-6 PUFA, so they can benefit from n-3 PUFA supplementation, whereas patients with FADS variants associated with a lower endogenous production of n-3 PUFA, even with high dietary PUFA intake, still tends to have a lower n-3 PUFA level, so they benefit less from n-3 PUFA supplementations than patients with other FADS variants [168,172,173]. This suggests that in the future, a more personalized approach is needed.…”

Section: Role Of Unsaturated Fatty Acid Desaturases In Humans and Othmentioning

confidence: 99%

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Biological Role of Unsaturated Fatty Acid Desaturases in Health and Disease

Czumaj

Śledziński

2020

Nutrients

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Polyunsaturated fatty acids (PUFAs) are considered one of the most important components of cells that influence normal development and function of many organisms, both eukaryotes and prokaryotes. Unsaturated fatty acid desaturases play a crucial role in the synthesis of PUFAs, inserting additional unsaturated bonds into the acyl chain. The level of expression and activity of different types of desaturases determines profiles of PUFAs. It is well recognized that qualitative and quantitative changes in the PUFA profile, resulting from alterations in the expression and activity of fatty acid desaturases, are associated with many pathological conditions. Understanding of underlying mechanisms of fatty acid desaturase activity and their functional modification will facilitate the development of novel therapeutic strategies in diseases associated with qualitative and quantitative disorders of PUFA.

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Section: Role Of Unsaturated Fatty Acid Desaturases In Humans and Othmentioning

confidence: 99%

Section: Role Of Unsaturated Fatty Acid Desaturases In Humans and Othmentioning

confidence: 99%

Biological Role of Unsaturated Fatty Acid Desaturases in Health and Disease

Czumaj

Śledziński

2020

Nutrients

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“…According to the nutrition standards for the Polish population from 2017, trans-fatty acids should be in an amount "as low as it is possible to achieve in a diet providing the right nutritional value" [20]. Jazernik et al indicate the importance of these fatty acids in the pathogenesis of inflammatory bowel disease [21].…”

Section: E Influence Of Fats On the Development And Course Of Inflammmentioning

confidence: 99%

The Influence of Nutrients on Inflammatory Bowel Diseases

Jarmakiewicz-Czaja

Piątek

Filip

2020

Journal of Nutrition and Metabolism

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Inflammatory bowel diseases is a group of inflammatory diseases. e pathogenesis of diseases is multifactorial, which may include a Western-type diet. Diseases occur with periods of recurrence and remission. Many factors can have a beneficial effect on reducing the frequency of recurrence and prolonging the remission period. Such ingredients include dietary fibre, mono-and polyunsaturated fatty acids, certain vitamins (D, C, and E), flavonoids, and minerals such as zinc and selenium. Properly selected nutrition might be an integral part of the treatment of patients with Crohn's disease or ulcerative colitis.

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“…Considerable evidence points toward the association of palmitic acid with IBD pathogenesis. 39 Palmitic acid exerts its anti-inflammatory effect through the immunomodulatory effects of lipid mediators and is widely implicated in the process of chronic inflammation. 40 Thus, palmitic acid could be considered as a potential biomarker for IBD diagnosis.…”

Section: Arachidonic Acid Metabolismmentioning

confidence: 99%

UPLC–QTOF-MS-Based Plasma Lipidomic Profiling Reveals Biomarkers for Inflammatory Bowel Disease Diagnosis

et al. 2019

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Identification of new biomarkers may help in the early diagnosis of inflammatory bowel disease (IBD). In this study, ultrahigh-performance liquid chromatography equipped with quadrupole time-of-flight mass spectrometry (UPLC−QTOF-MS) was used to analyze the untargeted lipidomics and compare plasma lipid profiles between IBD patients and control subjects. The principal component analysis and partial least-squares-discriminant analysis were carried out to distinguish IBD patients from control subjects. Using univariate and multivariate analysis, 55 significantly different metabolites from five lipid classes, fatty acyls (n = 19), glycerophospholipids (n = 5), prenol lipids (n = 10), sphingolipids (n = 2), and sterol lipids (n = 19) were identified. Forty-four of the 55 metabolites were analyzed by receiver operating characteristic (ROC) curve and area under curve (AUC) of >0.80. After validation in an independent cohort, IBD patients were differentiated from the control subjects by significantly altered plasma level of palmitic acid, 7alpha, 25-dihydroxycholesterol, 20-hydroxyeicosatetraenoic (HETE)-d6, (+/−)5,6-epoxyeicosatrienoic acid (EpETrE), docosahexaenoic acid (DHA), 9-heptadecylenic acid, lactucaxanthin, α-carotene, traumatic acid, and neoquassin with both sensitivity and specificity above 80%. Pathway analysis suggested that IBD dysregulation was related to the biosynthesis of primary bile acid, the metabolism of arachidonic acid, the metabolism of sphingolipid, fatty acid elongation, and glycerophospholipid metabolism. Our results suggest that the lipidomic profiling of patients plasma could be a potential method for IBD diagnosis.

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Comprehensive genetic study of fatty acids helps explain the role of noncoding inflammatory bowel disease associated SNPs and fatty acid metabolism in disease pathogenesis

Cited by 9 publications

References 63 publications

Biological Role of Unsaturated Fatty Acid Desaturases in Health and Disease

Biological Role of Unsaturated Fatty Acid Desaturases in Health and Disease

The Influence of Nutrients on Inflammatory Bowel Diseases

UPLC–QTOF-MS-Based Plasma Lipidomic Profiling Reveals Biomarkers for Inflammatory Bowel Disease Diagnosis

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