Comprehensive framework for human health risk assessment of nanopesticides

Kah, Mélanie; Johnston, Linda J.; Kookana, Rai S.; Bruce, Wendy; Haase, Andrea; Ritz, Vera; Dinglasan, J.; Doak, Shareen H.; Garelick, Hemda; Gubala, Vladimir

doi:10.1038/s41565-021-00964-7

Cited by 60 publications

(41 citation statements)

References 54 publications

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“…Both NCs-delivered pesticides and other pesticides at nanoscale (defied as nanopesticides) has been a growing concern for the public due to their toxicological risk assessment. Meanwhile, a unified assessment criterion is also needed before commercialization [ 1 ]. The European Food Safety Authority (EFSA) have made a guidance for risk assessment of nanopesticides in food and feed, suggesting all the accessory ingredient that contributes to final pesticidal effects should be concerned, including coformulants/excipients such as surfactants, solvents, carriers, and wetting agents [ 88 ].…”

Section: Challenges and Perspectivementioning

confidence: 99%

“…The European Food Safety Authority (EFSA) have made a guidance for risk assessment of nanopesticides in food and feed, suggesting all the accessory ingredient that contributes to final pesticidal effects should be concerned, including coformulants/excipients such as surfactants, solvents, carriers, and wetting agents [ 88 ]. Recently, two comprehensive frameworks for risk assessment of nanopesticides about human health or ecology have been reviewed [ 1 , 89 ]. The additional concerns and tests in risk assessment were suggested even all the ingredients of a certain nanoformulation was safe, because the nanopesticides with unique characteristics at nanoscale might have a distinct fate and behavior [ 1 ].…”

Section: Challenges and Perspectivementioning

confidence: 99%

“…Recently, two comprehensive frameworks for risk assessment of nanopesticides about human health or ecology have been reviewed [ 1 , 89 ]. The additional concerns and tests in risk assessment were suggested even all the ingredients of a certain nanoformulation was safe, because the nanopesticides with unique characteristics at nanoscale might have a distinct fate and behavior [ 1 ]. The evaluation of NCs toxicity still has difficulties and the toxicokinetics of NCs are also challenged [ 90 ].…”

Section: Challenges and Perspectivementioning

confidence: 99%

“…For this reason, the ideal models and toxicity predictions in field or in organisms are still scarce. The experience gained in the area of nanomedicine might help characterize and assess nanopesticides [ 1 ]. In summary, much remains to be discovered in the world of nanopesticides risk assessment.…”

Section: Challenges and Perspectivementioning

confidence: 99%

“…To feed nearly 10 billion people by 2050, food production would need to increase at least 50% from the 2012 level [ 1 ]. Chemical pesticides, as one of the most favorable ways for plant protection, have been there used extensively to reduce productive loss caused by pests [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

NCs-Delivered Pesticides: A Promising Candidate in Smart Agriculture

Hou

Zhang

Bao

et al. 2021

IJMS

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Pesticides have been used extensively in the field of plant protection to maximize crop yields. However, the long-term, unmanaged application of pesticides has posed severe challenges such as pesticide resistance, environmental contamination, risk in human health, soil degradation, and other important global issues. Recently, the combination of nanotechnology with plant protection strategies has offered new perspectives to mitigate these global issues, which has promoted a rapid development of NCs-based pesticides. Unlike certain conventional pesticides that have been applied inefficiently and lacked targeted control, pesticides delivered by nanocarriers (NCs) have optimized formulations, controlled release rate, and minimized or site-specific application. They are receiving increasing attention and are considered as an important part in sustainable and smart agriculture. This review discussed the limitation of traditional pesticides or conventional application mode, focused on the sustainable features of NCs-based pesticides such as improved formulation, enhanced stability under harsh condition, and controlled release/degradation. The perspectives of NCs-based pesticides and their risk assessment were also suggested in this view for a better use of NCs-based pesticides to facilitate sustainable, smart agriculture in the future.

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Section: Challenges and Perspectivementioning

confidence: 99%

Section: Challenges and Perspectivementioning

confidence: 99%

Section: Challenges and Perspectivementioning

confidence: 99%

Section: Challenges and Perspectivementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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NCs-Delivered Pesticides: A Promising Candidate in Smart Agriculture

Hou

Zhang

Bao

et al. 2021

IJMS

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A pH‐responsive MOF‐functionalized hollow mesoporous silica controlled herbicide delivery system exhibits enhanced activity against ACCase‐herbicide‐resistant weeds

Deng,

Li,

et al. 2023

Pest Management Science

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BACKGROUNDWeeds grow aggressively in agricultural fields, leading to reduced crop yields and an inability to meet the growing demand for food. Herbicides are currently the most effective method for weed control. However, the overuse of herbicides has resulted in the evolution of resistance mutants and has caused environmental pollution. Therefore, new technologies are urgently required to address this global challenge.RESULTSWe report a copper‐benzene‐1,4‐dicarboxylate metal organic framework (Cu‐BDC MOF)‐functionalized carboxyl hollow mesoporous silica (HMS‐COOH) delivery system for the pH‐controlled release of the acetyl‐CoA carboxylase (ACCase)‐inhibiting herbicide quizalofop‐p‐ethyl (QE). The delivery system (QE@HMS@Cu‐BDC) enabled the efficient control of barnyard grasses that are susceptible and resistant to ACCase‐inhibiting herbicides, which showed 93.33% and 88.33% fresh weight control efficacy at 67.5 g ha‐1, resepcitviely. With the lowest pH value (3), QE and copper ion were released slowly 70.30% and 78.55% from QE@HMS@Cu‐BDC after 89 hours, respectively. QE@HMS@Cu‐BDC showed better absorption, conduction, transportation, and ACCase activity inhibition performance than that of QE emulsifiable concentrate (EC) in both susceptible and ACCase‐herbicide resistant barnyard grasses. In addition, with the safener effect of carrier HMS@Cu‐BDC and the aid of the safener fenchlorazole‐ethyl (FE), the application of QE@HMS@Cu‐BDC was shown to mitigate the damage caused by QE to rice plant.CONCLUSIONThis work first found this new material (HMS‐COOH@Cu‐BDC) could be used to mitigate herbicide‐induced oxidative stress and improve rice plant safety. Futhermore, the QE@HMS‐COOH@Cu‐BDC constructed in this research might be used as an efficient nano pesticide formulation for weed controls in paddy rice fields.This article is protected by copyright. All rights reserved.

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Nanopesticides: A Review on Current Research and Future Perspective

Paradva,

Kalla

2023

ChemistrySelect

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The survival of humans depends critically on crop production, making crop protection absolutely essential. Numerous studies have suggested that nanopesticides could soon fully replace conventional pesticides since they are far more effective than those now in use. Due to an increase in their surface‐to‐volume ratio, nanomaterials exhibit different properties from their bulk counterparts. Nanopesticides are pesticides that have been made with these nanoparticles and have a high application efficiency and significantly fewer hazardous environmental impacts than pesticides that have been made chemically. Various formulation strategies, which include the containment of the active substance by the nanoparticles, have previously been established, exhibiting promising effects on the pests. Target specificity, high stability, and controlled active ingredients (AIs) release are a few of the noteworthy qualities these nanopesticides offer. The development of green nanopesticides derived from nature, which have very low ecotoxicities and nanoscale qualities, can also have a significant positive impact on crop output. However, before being mass‐produced and used, the discovery still has to be thoroughly examined to determine its effects on people and the environment due to the lack of conclusive proof demonstrating its toxicity. This paper aims to represent the use of nanopesticides in crop protection and a detailed overview of the various methods for the formulation of nanopesticides. Also, the possible negative impacts on the non‐target species by the application of nanopesticides have been briefly discussed. The need for the development of green nanopesticides to avoid the negative aspects of nanopesticides has also been highlighted.

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Comprehensive framework for human health risk assessment of nanopesticides

Cited by 60 publications

References 54 publications

NCs-Delivered Pesticides: A Promising Candidate in Smart Agriculture

NCs-Delivered Pesticides: A Promising Candidate in Smart Agriculture

A pH‐responsive MOF‐functionalized hollow mesoporous silica controlled herbicide delivery system exhibits enhanced activity against ACCase‐herbicide‐resistant weeds

Nanopesticides: A Review on Current Research and Future Perspective

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