Comprehensive examination of tattoo removal using a 150 ps Nd:YAG laser in a porcine model

Abstract

This study aimed to investigate the efficacy of a Nd:YAG laser with a pulse duration of 150 ps at different laser parameters. The effects on multiple-colored tattoos with such ultrashort pulses has not been previously described in the literature. In vivo experiments were conducted on porcine skin to analyze the fragmentation efficiency of five different tattoo colors using different wavelengths, pulse energies, and spot sizes. The results showed that the optimal tattoo clearance to safety ratio for blue, green, red, and yellow tattoos with a 532 nm wavelength was 0.96–2.39 J/cm2. The laser with a wavelength of 1064 nm demonstrated the highest efficacy in eliminating black tattoos, with positive results observed for green and blue pigments at a fluence of 3.02 J/cm2. The study provides valuable insights into the efficacy of laser treatment with 150 ps for removing tattoos of different colors using different laser parameters. This information can help dermatologists and practitioners perform more efficient and effective tattoo removal with fewer side effects.

Assessing the efficacy of a 100 ps Nd:YAG laser for tattoo removal in a minipig model

“…Mononuclear cells, which include macrophages and lymphocytes, play a pivotal role in the immune response to tissue injury [5]. Their infiltration indicates an active immune response to the laser-induced thermal damage, which is crucial in clearing the fragmented tattoo pigments [6]. Interestingly, it was also observed that the severity of this mononuclear cell infiltration was directly influenced by the quantity of pigment deposits in the skin.…”

“…To overcome these challenges, ongoing research investigates novel approaches to enhance colored tattoo clearance. This includes exploring new laser wavelengths, combination therapies with beam-splitting optics [5], and pulse durations, as demonstrated in our previous study using a 150 ps Nd: YAG laser for treating multicolored tattoos in a porcine model [6].…”