Comprehensive evaluation of the combined extracts of Epimedii Folium and Ligustri Lucidi Fructus for PMOP in ovariectomized rats based on MLP-ANN methods

Ma, Zitong; Li, Xiaoxi; Chen, Yuheng; Tang, Xian‐Liang; Yingying, Gao; Wang, Han; Liu, Renhui

doi:10.1016/j.jep.2020.113563

Cited by 11 publications

(11 citation statements)

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“…The least significant difference (LSD) test when the variances were equal or Tamhane's T2 test when the variances were not equal was used for comparisons between individual groups and to determine which means differed significantly statistically (P < 0:05). and retinoic acid-induced OP [15][16][17]23]. However, we still do not know the physical basis and effective components of EF, LLF, and EF&LLF.…”

Section: Western Blot (Wb)mentioning

confidence: 99%

“…Our previous researches have confirmed that EF&LLF has bone-protective effects by regulating bone remodeling in OVX-induced, natural aging-induced, glucocorticoidinduced, and retinoic acid-induced OP rats [15][16][17][18]. However, the effects of EF&LLF on the growth and differentiation of OBs and OCs and their communication at the cellular level are still unclear.…”

Section: Introductionmentioning

confidence: 99%

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Epimedii Folium and Ligustri Lucidi Fructus Promote Osteoblastogenesis and Inhibit Osteoclastogenesis against Osteoporosis via Acting on Osteoblast-Osteoclast Communication

Tang

Chen

et al. 2023

Oxidative Medicine and Cellular Longevity

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Osteoblast (OB) and osteoclast (OC) play important roles in bone formation and bone resorption, which can communicate with each other through cytokine paracrine. Previous studies have confirmed that Epimedii Folium (EF) and Ligustri Lucidi Fructus (LLF) used alone or in combination can treat osteoporosis (OP) through regulating bone remodeling, but the effects of EF and LLF on osteoblastogenesis, osteoclastogenesis, and OB-OC communication are unclear. In this study, we investigated the direct and indirect effects of EF and LLF on OBs and OCs via monoculture and coculture (transwell) models of OBs and OCs. We found that the combination of EF and LLF (EF&LLF) could promote osteoblastogenesis and inhibit osteoclastogenesis directly and indirectly. In order to study the mechanisms of EF&LLF on indirectly regulating osteoblastogenesis and osteoclastogenesis, we detected the expression of cytokines by which OBs and OCs could communicate with each other. We found that EF&LLF could downregulate the expression of RANKL and M-CSF and the protein ratio of RANKL/OPG of OBs and Atp6v0d2 expression of OCs and upregulate the expression of OPG and TGF-β1 of OBs and the expression of TGF-β1, BMP-2, and IGF-1 of OCs, indicating that EF&LLF could regulate cytokine expressions of OBs/OCs to affect OB-OC communication. In addition, EF&LLF had a better effect on regulating cytokines of OBs and OCs than EF or LLF in single use. This study suggested that EF&LLF exhibited the effects of promoting osteoblastogenesis and inhibiting osteoclastogenesis via acting on OB-OC communication and provided some scientific evidences for EF&LLF against OP.

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Section: Western Blot (Wb)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Epimedii Folium and Ligustri Lucidi Fructus Promote Osteoblastogenesis and Inhibit Osteoclastogenesis against Osteoporosis via Acting on Osteoblast-Osteoclast Communication

Tang

Chen

et al. 2023

Oxidative Medicine and Cellular Longevity

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“…In TCM, kidney deficiency is the main pathogenesis of osteoporosis based on the theory of “kidney governing bones” [ 57 ]. On the other hand, modern clinical and preclinical research showed that liver-spleen-kidney insufficiency may result in the development of diabetic osteoporosis [ 58 ].…”

Section: Tcm Characteristicsmentioning

confidence: 99%

Antiosteoporosis Studies of 20 Medicine Food Homology Plants Containing Quercetin, Rutin, and Kaempferol: TCM Characteristics, In Vivo and In Vitro Activities, Potential Mechanisms, and Food Functions

Shen

Feng

Zhang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Dietary nutraceutical compounds have been evidenced as backbone for bone health in recent years. It is reported that medicine food homology (MFH) plants have multiple nutraceutical compounds. Based on our literature research, 20 MFH plants caught our attention because they contain three popular antiosteoporosis compounds simultaneously: quercetin, rutin, and kaempferol. According to traditional Chinese medicine (TCM), their characteristics including natures, flavors, attributive to meridian tropism, and efficacies were listed. The relationships between TCM efficacies, such as “heat clearing,” “tonic,” and “the interior warming,” and antiosteoporosis pharmacological actions such as antioxidant and immune regulation were discussed. The in vivo antiosteoporosis effects of the 20 MFH plants were summarized. The in vitro antiosteoporosis activities and related mechanisms of the 20 plants and quercetin, rutin, kaempferol were detailed. The TGF-β-Smad signaling, fibroblast growth factor, and Wnt/β-catenin signaling on bone formation and the RANKL signaling, NF-κB signaling, and macrophage-colony-stimulating factor on bone resorption were identified. From food point, these 20 MFH plants could be classified as condiment, vegetable, fruit, tea and related products, beverage, etc. Based on the above discussion, these 20 MFH plants could be used as daily food supplements for the prevention and treatment against osteoporosis.

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“…Compared with singlelayer perceptual neural network, MLP is more suitable for medical data analysis to solve complex linear and indivisible multiclassification problems. For example, MLP combined with artificial neural network (ANN) model can be used to evaluate the efficacy of drugs [7]. The MLP model can also be used for the diagnosis of glomerular filtration rate in patients with polycystic kidney disease and to help judge the progression of the disease [8].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Perioperative Nursing for Patients with Hepatobiliary Pancreatic Diseases Combined with Diabetes Mellitus Based on Multilayer Perceptron Neural Network

Zhang

Meng

2022

Wireless Communications and Mobile Computing

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Objective. To analyze the perioperative nursing methods for patients with hepatobiliary pancreatic diseases combined with diabetes mellitus and to evaluate the differences in nursing methods based on a multilayer perceptron (MLP) neural network. Methods. 80 patients with hepatobiliary and pancreatic diseases complicated with diabetes admitted to our hospital from January 2021 to January 2022 were selected as subjects. According to different nursing methods, two groups of hepatobiliary and pancreatic diseases with diabetes were randomly divided into the control group and the experimental group, 40 patients in each group, two groups were given routine nursing care, and the experimental group was given perioperative nursing intervention on the basis of routine nursing. The fasting blood glucose (FBG), postprandial two-hour blood glucose (2hPG), and glycosylated hemoglobin (HbA1c) index of two groups of patients with hepatobiliary pancreatic diseases and diabetes mellitus were observed and compared. The incidence of postoperative complications, the average hospitalization time of patients, and the clinical nursing satisfaction rate of patients were observed and compared. Results. The blood glucose level including FBG, 2hPG, and HbA1c in the experimental group were better than those in the control group, and the data comparison difference was statistically significant ( P < 0.01 ). The incidence of postoperative complications in the experimental group was lower than that in the control group, and the data comparison difference was statistically significant ( P < 0.05 ). The discharge time of patients in the experimental group was significantly shorter than that in the control group, and the satisfaction rate was significantly higher than that in the control group ( P < 0.05 ). The comprehensive analysis based on MLP neural network model confirmed that perioperative surgical nursing can improve the treatment effect of patients. Conclusion. In the perioperative period of patients with hepatobiliary and pancreatic diseases combined with diabetes, the implementation of comprehensive and comprehensive nursing intervention will help to improve the effect of surgical treatment and postoperative recovery.

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Comprehensive evaluation of the combined extracts of Epimedii Folium and Ligustri Lucidi Fructus for PMOP in ovariectomized rats based on MLP-ANN methods

Cited by 11 publications

References 66 publications

Epimedii Folium and Ligustri Lucidi Fructus Promote Osteoblastogenesis and Inhibit Osteoclastogenesis against Osteoporosis via Acting on Osteoblast-Osteoclast Communication

Epimedii Folium and Ligustri Lucidi Fructus Promote Osteoblastogenesis and Inhibit Osteoclastogenesis against Osteoporosis via Acting on Osteoblast-Osteoclast Communication

Antiosteoporosis Studies of 20 Medicine Food Homology Plants Containing Quercetin, Rutin, and Kaempferol: TCM Characteristics, In Vivo and In Vitro Activities, Potential Mechanisms, and Food Functions

Evaluation of Perioperative Nursing for Patients with Hepatobiliary Pancreatic Diseases Combined with Diabetes Mellitus Based on Multilayer Perceptron Neural Network

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