Comprehensive evaluation of Bletilla striata and its substitutes by combining phenotypic characteristic, chemical composition, and anti-melanogenic activity

Wang, Rongbin; Qin, Ya-Dong; Zhou, Juanjuan; Wang, Juan; Shu, Huiyun; Zhou, Shoubiao; Peng, Xin

doi:10.1016/j.phytochem.2021.113059

Cited by 8 publications

(3 citation statements)

References 23 publications

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“…Bletilla striata has a wide range of applications in pharmacological and cosmetic fields, because of the shortage of resources, there are some substitutes. To distinguish the differences and homologies, a UHPLC fingerprint analysis coupled with chemometric methods were developed for characterization and quality control ( Wang et al, 2022 ). The stems of Kadsura interior A. C. Smith has the efficacy of tonifying and invigorating the blood.…”

Section: Application Of Uhplc-hrmsmentioning

confidence: 99%

The Application of UHPLC-HRMS for Quality Control of Traditional Chinese Medicine

Shi

et al. 2022

Front. Pharmacol.

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UHPLC-HRMS (ultra-high-performance liquid chromatography-high resolution mass spectrometry) is a new technique that unifies the application of UHPLC with HRMS. Because of the high sensitivity and good separation ability of UHPLC and the sensitivity of HRMS, this technique has been widely used for structure identification, quantitative determination, fingerprint analysis, and elucidation of the mechanisms of action of traditional Chinese medicines (TCMs) in recent years. This review mainly outlines the advantages of using UHPLC-HRMS and provides a survey of the research advances on UHPLC-HRMS for the quality control of TCMs.

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Section: Application Of Uhplc-hrmsmentioning

confidence: 99%

The Application of UHPLC-HRMS for Quality Control of Traditional Chinese Medicine

Shi

et al. 2022

Front. Pharmacol.

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“…The dihydrophenanthrene from Bletilla striata induced the apoptosis of human hepatoma cells (HepG 2 ) by downregulating expression of cyclin B1 and blocking the G 2 /M phase of the cell cycle 23 . Several active substances including coelonin were identified as the potential chemical markers for characterization and quality evaluation of Bletillae striata 24 . Among them, the tawny powder coelonin (2,7‐dihydroxy‐4‐methoxy‐9,10‐dihydrophenanthrene) could significantly downregulated many different phosphorylated proteins, which were closely related to the response of LPS‐induced signal transduction, immune response and cell proliferation 21 …”

Section: Introductionmentioning

confidence: 99%

“…23 Several active substances including coelonin were identified as the potential chemical markers for characterization and quality evaluation of Bletillae striata. 24 Among them, the tawny powder coelonin (2,7-dihydroxy-4-methoxy-9,10-dihydrophenanthrene) could significantly downregulated many different phosphorylated proteins, which were closely related to the response of LPS-induced signal transduction, immune response and cell proliferation. 21 Previous research indicated that coelonin suppressed production of inflammatory factors in LPS induced mouse primary peritoneal macrophage and showed anti-inflammatory activity.…”

mentioning

confidence: 99%

Coelonin protects against PM₂_.5‐induced macrophage damage via suppressing TLR4/NF‐κB/COX‐2 signaling pathway and NLRP3 inflammasome activation in vitro

Bao

Wang

et al. 2023

Environmental Toxicology

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One of the important monitoring indicators of the air pollution is atmospheric fine particulate matter (PM 2.5 ), which can induce lung inflammation after inhalation. Coelonin can alleviate PM 2.5 -induced macrophage damage through anti-inflammation.However, its molecular mechanism remains unclear. We hypothesized that macrophage damage may involve the release of inflammatory cytokines, activation of inflammatory pathways, and pyrosis induced by inflammasome. In this study, we evaluated the anti-inflammation activity of coelonin in PM 2.5 -induced macrophage and its mechanism of action. Nitric oxide (NO) and reactive oxygen species (ROS) production were measured by NO Assay kit and dichlorofluorescein-diacetate (DCFH-DA), and apoptosis were measured by Flow cytometry and TUNEL staining. The concentration of inflammatory cytokines production was measured with cytometric bead arrays and ELISA kits. The activation of NF-κB signaling pathway and NLRP3 inflammasome were measured by immunofluorescence, quantitative reverse transcription-polymerase chain reaction and western blot. As expected, coelonin pretreatment reduced NO production significantly as well as alleviated cell damage by decreasing ROS and apoptosis. It decreased generation of interleukin (IL)-6 and tumor necrosis factor (TNF)-α in PM 2.5 -induced RAW264.7 and J774A.1 cells. Moreover, coelonin markedly inhibited upregulating the expression of toll-like receptor (TLR)4 and cyclo-oxygenase (COX)-2, blocked activation of p-nuclear factor-kappa B (NF-κB) signaling pathway, and suppressed expression of NLRP3 inflammasome, ASC, GSDMD, IL-18 and IL-1β. In conclusion, the results showed that coelonin could protect against PM 2.5 -induced macrophage damage via suppressing TLR4/NF-κB/ COX-2 signaling pathway and NLRP3 inflammasome activation in vitro.

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Chemical structures and anti-tyrosinase activity of the constituents from Elephantopus scaber L

Bai

et al. 2022

Fitoterapia

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Comprehensive evaluation of Bletilla striata and its substitutes by combining phenotypic characteristic, chemical composition, and anti-melanogenic activity

Cited by 8 publications

References 23 publications

The Application of UHPLC-HRMS for Quality Control of Traditional Chinese Medicine

The Application of UHPLC-HRMS for Quality Control of Traditional Chinese Medicine

Coelonin protects against PM₂_.5‐induced macrophage damage via suppressing TLR4/NF‐κB/COX‐2 signaling pathway and NLRP3 inflammasome activation in vitro

Chemical structures and anti-tyrosinase activity of the constituents from Elephantopus scaber L

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Comprehensive evaluation of Bletilla striata and its substitutes by combining phenotypic characteristic, chemical composition, and anti-melanogenic activity

Cited by 8 publications

References 23 publications

The Application of UHPLC-HRMS for Quality Control of Traditional Chinese Medicine

The Application of UHPLC-HRMS for Quality Control of Traditional Chinese Medicine

Coelonin protects against PM2.5‐induced macrophage damage via suppressing TLR4/NF‐κB/COX‐2 signaling pathway and NLRP3 inflammasome activation in vitro

Chemical structures and anti-tyrosinase activity of the constituents from Elephantopus scaber L

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Product

Resources

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Coelonin protects against PM₂_.5‐induced macrophage damage via suppressing TLR4/NF‐κB/COX‐2 signaling pathway and NLRP3 inflammasome activation in vitro