Comprehensive evaluation of antioxidant effects of Japanese Kampo medicines led to identification of Tsudosan formulation as a potent antioxidant agent

Sato, Naoko; Li, Wei; Takemoto, Hiroaki; Takeuchi, Mio; Nakamura, Akihiro; Tokura, Emi; Akahane, Chie; Ueno, Kanako; Komatsu, Kana; Kuriyama, Noriko; Onoda, Toshihisa; Higai, Koji; Koike, Kazuo

doi:10.1007/s11418-018-1259-x

Cited by 6 publications

(12 citation statements)

References 23 publications

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“…These results suggested that HJG may reduce oxidative stress in cells. However, in a previous report that comprehensively analyzed the ability of Kampo medicines to scavenge reactive oxygen species, none of these Kampo medicines had high in vitro/in vivo antioxidant activity (Sato et al 2019), suggesting that their physiological effects may be other than the reduction of oxidative stress.…”

Section: Referencesmentioning

confidence: 96%

Protective effects of hachimijiogan (HJG), a Japanese Kampo medicine, on cancer cachectic muscle wasting in mice

KAMETAKA,

ISOBE,

KOMATA

et al. 2023

Biomed. Res.

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Myogenesis is required to generate skeletal muscle tissue and to maintain skeletal muscle mass. Decreased myogenesis under various pathogenic conditions results in muscular atrophy. Through a small screening of Japanese traditional (Kampo) medicines, hachimijiogan (HJG) was shown to promote the myogenic differentiation of C2C12 myoblasts through the upregulation of myogenin. In tumor-bearing cancer-cachectic mice, HJG was also found to have a protective effect against cancer-cachectic muscle wasting. This effect was significant when HJG was administered in combination with aerobic exercise by treadmill running. Moreover, HJG ameliorated the cellular atrophy of C2C12 myotubes induced by treatment with conditioned medium derived from a colon-26 cancer cell culture. In addition, HJG suppressed H 2 O 2 -dependent myotube atrophy, suggesting that HJG could reverse the atrophic phenotypes by eliminating reactive oxygen species.

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Section: Referencesmentioning

confidence: 96%

Protective effects of hachimijiogan (HJG), a Japanese Kampo medicine, on cancer cachectic muscle wasting in mice

KAMETAKA,

ISOBE,

KOMATA

et al. 2023

Biomed. Res.

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“…Daesiho-tang (DSHT) is an herbal medicine known to have antifungal, 10 antioxidant, 11 antidiabetic, 12 anti-obesity, 13 hepatoprotective, 14 and lipid metabolism regulatory effects. 15 DSHT has been used for treating various diseases such as cholecystitis and cholelithiasis.…”

Section: Introductionmentioning

confidence: 99%

“… 16 Qian et al 14 reported that DSHT was effective in improving fatty liver and diabetes by reducing insulin resistance and inhibiting inflammation through SIRT1 and NF-kB regulatory mechanisms. Zhang et al 12 reported that insulin resistance, glucose metabolism, and lipid metabolism were significantly improved after DSHT was administered to patients with diabetes who were receiving conventional diabetic treatment. There was a clinical report that showed the improvement of urticaria by DSHT.…”

Section: Introductionmentioning

confidence: 99%

Chronic Atopic Dermatitis with Eosinophilia Improved by Daesiho-Tang: A Case Report

Park,

Lee,

Seong

et al. 2023

CCID

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Purpose This study is to report a case of chronic atopic dermatitis (AD) with eosinophilia, which did not respond to conventional therapy and was improved by Daesiho-tang (DSHT). Patients and Methods The patient visited our clinic with symptoms of atopic dermatitis including skin lesions and pruritus. Based on her symptoms, DSHT was prescribed. At each visit, the Scoring Atopic Dermatitis (SCORAD), Dermatology Life Quality Index (DLQI), and accompanying systemic symptoms (ASS) were measured. Multiple Allergen Simultaneous Test (MAST) was initially performed for 108 allergens and analyzed by Western blotting using an Alternate Scoring Method (ASM) according to the specific IgE concentration. Also, peripheral blood laboratory (Lab) tests were performed three times during the patient’s visit. Results After taking DSHT, the total SCORAD score improved from 62.9 to 23.5, while the patient’s ASS also improved. The DLQI score improved from 19 to 5. The total number of eosinophils in the peripheral blood, which showed a mild increase, recovered from 17.2% (0.98 x10 3 /μL) to 4.5% (0.24 x10 3 /μL). The total IgE slightly decreased, while AST and ALT were also restored to normal ranges. Conclusion Based on this case, DSHT is considered a potential alternative treatment for AD.

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“…Production of excess free radicals induces immune dysfunction, which causes lipid peroxidation damage in cell membranes, enzyme deactivation, and oxidative DNA damage, leading to many oxidation-related diseases [1,2]. Consequently, there has been an increase in research activity focusing on the synthesis and development of free radical scavengers [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Radical-Scavenging Activities, and Protective Effects against AAPH-Induced Oxidative Damage in DNA and Erythrocytes of Piperine Derivatives

Qin

Yang

Cao

2020

Journal of Chemistry

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Piperine amino acid derivatives containing phenolic hydroxyl groups were synthesized using piperine as the raw material by amide hydrolysis, amidation, ester hydrolysis, and deacetalization. The obtained products were characterized by mass spectrometry and nuclear magnetic resonance. The antioxidant activity of the piperine derivatives was evaluated by the DPPH and ABTS scavenging rates and the total antioxidant capacity. The results showed that the piperine amino acid (4a–4d) had relatively weak radical-scavenging ability, while the piperine amino acid derivatives (5a–5d) containing phenolic hydroxyl groups had significant radical-scavenging effects. In addition, the total reducing ability of 5a–5d was better than that of piperine. The study also found that piperine derivatives containing phenolic hydroxyl groups played an important role in inhibiting oxidative damage in DNA and erythrocytes.

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Comprehensive evaluation of antioxidant effects of Japanese Kampo medicines led to identification of Tsudosan formulation as a potent antioxidant agent

Cited by 6 publications

References 23 publications

Protective effects of hachimijiogan (HJG), a Japanese Kampo medicine, on cancer cachectic muscle wasting in mice

Protective effects of hachimijiogan (HJG), a Japanese Kampo medicine, on cancer cachectic muscle wasting in mice

Chronic Atopic Dermatitis with Eosinophilia Improved by Daesiho-Tang: A Case Report

Synthesis, Radical-Scavenging Activities, and Protective Effects against AAPH-Induced Oxidative Damage in DNA and Erythrocytes of Piperine Derivatives

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