Comprehensive evaluation and treatment of 75 men referred to chronic prostatitis clinic

Krieger, John N.; Egan, Kelly J.

doi:10.1016/0090-4295(91)80004-q

Cited by 68 publications

(22 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…6 Seminal plasma and cell aliquots were stored at j 70-C for later polymerase chain reaction (PCR) analysis within 6 hours of collection. 5,7,8 Semen analyses followed our published methods, 9,10 including staining to discriminate leukocytes from immature sperm forms. Computerized strict criteria morphology on Papanicolaou-stained thin smears was performed using the Hamilton Thorne Research BDimensionsp rogram (Hamilton Thorne Biosciences, Inc., Beverly, MA).…”

Section: Semen Processing Staining and Analysismentioning

confidence: 99%

Lower Genitourinary Tract Sources of Seminal HIV

Coombs¹,

Lockhart²,

Ross³

et al. 2006

JAIDS Journal of Acquired Immune Deficiency Syndromes

Self Cite

View full text Add to dashboard Cite

These data indicate that distal genitourinary sources other than the prostate appear to be the major source of seminal HIV in men without clinical urethritis or prostatitis. Because the HIV RNA level in blood plasma is not reliable as an independent clinical predictor of virus levels in seminal plasma, these findings also extend the concept that the male genital tract is a distinct virological compartment from blood.

show abstract

Section: Semen Processing Staining and Analysismentioning

confidence: 99%

Lower Genitourinary Tract Sources of Seminal HIV

Coombs¹,

Lockhart²,

Ross³

et al. 2006

JAIDS Journal of Acquired Immune Deficiency Syndromes

Self Cite

View full text Add to dashboard Cite

show abstract

“…This constellation of symptoms would suggest that an infection in the prostate gland is present, but the pathological basis for CP/CPPS has not yet been defined, as the presence of an infectious agent can be demonstrated in only 5-10% of patients with symptoms suggestive of CP/CPPS. 1,2 However, despite evidence indicating that only 5-10% of symptomatic men have positive cultures localized to the prostate gland, most physicians continue to prescribe antibiotics for this condition.…”

Section: Introductionmentioning

confidence: 99%

More effects of extracorporeal magnetic innervation and terazosin therapy than terazosin therapy alone for non-inflammatory chronic pelvic pain syndrome: a pilot study

Paick

2006

Prostate Cancer Prostatic Dis

View full text Add to dashboard Cite

The objective of this study was to evaluate whether extracorporeal magnetic innervation (ExMI) combined with a-blocker therapy is more effective than a-blocker monotherapy for patients with non-inflammatory chronic prostatitis (CP)/chronic pelvic pain syndrome (CPPS), category IIIB. Patients were randomized to either terazosin monotherapy (group 1, n ¼ 21) or terazosin combined with ExMI therapy (group 2, n ¼ 19). Patients in group 2 had 12 treatment sessions of ExMI twice a week during 6 weeks. None of the patients experienced any side effects from treatment. The changes in each domain of the National Institutes of Health (NIH)-Chronic Prostatitis Symptom Index (CPSI) measured on week 6 were not significantly different between the groups. However, the difference (median, 25-75th percentiles) between the two groups in total NIH-CPSI scores was À4 (À11.5, À2) for group 1 and À12 (À17.3, À2.3) for group 2, respectively (P ¼ 0.047). At 6 weeks, 47.6% (10 of 21) of group 1 had a 425% decrease in total NIH-CPSI compared with 78.9% (15 of 19) of group 2 (P ¼ 0.041). Also, more patients in group 2 (78.9%) were rated as responders with a 6-point decrease in NIH-CPSI compared with group 1 (47.6%) (P ¼ 0.041). The early results suggest that ExMI combined with a-blocker therapy has better effect than a-blocker monotherapy for the treatment of CP/CPPS.

show abstract

“…With the advent of antimicrobial therapy, long courses of prostate-penetrating antimicrobials such as the fluoroquinolones became the mainstay of therapy. Traditionally, investigators hypothesized that microbial infections led to prostatic inflammation and caused the symptoms of prostatitis; however, more recent data suggest that more than 90% of patients present without a clear bacterial cause [3]. This inconsistency in identifying uropathogens in patients with symptoms of prostatitis has led to controversy in therapeutic management.…”

Section: Introductionmentioning

confidence: 95%

Role of bacteria in chronic prostatitis/ chronic pelvic pain syndrome

Hua

Williams²,

Schaeffer

2005

Curr Urol Rep

View full text Add to dashboard Cite

Throughout the past century, we have refined our understanding of prostatitis, moving from using a primarily clinical definition to considering it as a complex inflammatory condition. The inconsistency in identifying uropathogens in patients with symptoms of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) has led to controversy in therapeutic management. There is compelling evidence that the normal prostate has minimal inflammation and no bacteria. Clinicians using the Meares/Stamey criteria identified uropathogens localized to the prostate in only 6% to 8% of CP/CPPS patients. This suggests that bacteria may have a role in less than 10% of men with CP/CPPS. That some patients respond to antimicrobials could suggest that eradication of bacteria reduces symptoms. However, the beneficial effect of antimicrobial drugs may not be due to their antibacterial action, but to their anti-inflammatory action. The normal prostate shows minimal inflammation, but only 50% of CP/CPPS patients exhibit prostatic leukocytosis. Prudence demands that we examine the function of the white blood cells--the cytokines produced. Several basic science advances allowed new avenues of research regarding the detection of molecular evidence of causative uropathogens. New research brings new controversy and unexpected findings, but further refines our understanding of the immune system and the CP/CPPS disease process.

show abstract

Comprehensive evaluation and treatment of 75 men referred to chronic prostatitis clinic

Cited by 68 publications

References 31 publications

Lower Genitourinary Tract Sources of Seminal HIV

Lower Genitourinary Tract Sources of Seminal HIV

More effects of extracorporeal magnetic innervation and terazosin therapy than terazosin therapy alone for non-inflammatory chronic pelvic pain syndrome: a pilot study

Role of bacteria in chronic prostatitis/ chronic pelvic pain syndrome

Contact Info

Product

Resources

About