Abstract:Protein S is a glycoprotein essential in the regulation of blood coagulation. Familial protein S deficiency increases the risk of venous thromboembolism approximately 2-to 11-fold. Herein, we report this disorder in six members of a Vietnamese family among which three had thromboembolism, and the other three were asymptomatic. The protein S levels ranged from 10.1% to 24%, but we did not identify any PROS1 mutation. In one patient, a rare combination of protein C and S deficiency withPROC heterozygous c.565C>T… Show more
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