Comprehensive clinical follow-up of late effects in childhood cancer survivors shows the need for early and well-timed intervention

Han, Jung Woo; Kwon, Seung Yeon; Won, Soyoung; Shin, Yoo Jin; Ko, JeongGil; Lyu, Chuhl Joo

doi:10.1093/annonc/mdn778

Cited by 46 publications

(56 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the basis of these findings, we need to promote a further reduction of RT without a decrease in the survival rates. More studies on the long-term health effects in CCS are needed to improve the therapy in the future [26].…”

Section: Discussionmentioning

confidence: 99%

Late effects and quality of life of childhood cancer survivors: Part 2. Impact of radiotherapy

et al. 2010

View full text Add to dashboard Cite

To examine the late effects and health-related quality of life of childhood cancer survivors (CCS) after radiotherapy (RT), we performed a cross-sectional survey using self-rating questionnaires. The subjects were divided into 3 groups: CCS treated with or without RT, and a general population matched for age, gender, residential area, and work status. The numbers in each group were 113, 72, and 1,000, respectively. The median ages of CCS at diagnosis and the time of the survey were 8 and 22 years, respectively. The mean final heights of males and females were significantly lower in CCS with RT than in the other 2 groups. Risk factors for a short stature were total body irradiation (TBI) [odds ratio (OR) 17.8, p < 0.001], spinal irradiation (OR 8.31, p = 0.033), and an age younger than 10 years at diagnosis. Late effects were observed in 68% of CCS with RT compared with 36% of CCS without RT. Multivariate analysis revealed that TBI was significantly associated with endocrine dysfunction (OR 12.3), skull and spinal irradiation with cognitive dysfunction (OR 16.1 and 11.5, respectively), and spinal irradiation with a short stature (OR 14.1), respectively. Physical dysfunction, psychological stress, and problems of social adaptation were observed in >50% of CCS with RT.

show abstract

Section: Discussionmentioning

confidence: 99%

Late effects and quality of life of childhood cancer survivors: Part 2. Impact of radiotherapy

et al. 2010

View full text Add to dashboard Cite

show abstract

“…We have previously published a report on the overall health conditions of childhood cancer survivors seen at a long-term follow-up clinic (LTFC), the first one to be established in Korea (11). Here we report the follow-up data for these survivors.…”

Section: Introductionmentioning

confidence: 99%

Increasing and Worsening Late Effects in Childhood Cancer Survivors during Follow-up

Han

Kim

et al. 2013

J Korean Med Sci

View full text Add to dashboard Cite

Recent advances in childhood cancer treatment have increased survival rates to 80%. Two out of three survivors experience late effects (LEs). From a group of 241 survivors previously described, 193 were followed at the long-term follow-up clinic (LTFC) of Severance Hospital in Korea; the presence of LEs was confirmed by oncologists. We reported the change in LEs during 3 yr of follow-up. The median follow-up from diagnosis was 10.4 yr (5.1-26.2 yr). Among 193 survivors, the percentage of patients with at least one LE increased from 63.2% at the initial visit to 75.1% at the most recent visit (P = 0.011). The proportion of patients having multiple LEs and grade 2 or higher LEs increased from the initial visit (P = 0.001 respectively). Forty-eight non-responders to the LTFC were older and had less frequent and severe LEs than responders at initial visit (all P < 0.05). In multivariate analysis, younger age at diagnosis, older age at initial visit, a diagnosis of a brain tumor or lymphoma, and use of radiotherapy were significant risk factors for LEs (all P < 0.05). Adverse changes in LEs were seen among the survivors, regardless of most clinical risk factors. They need to receive comprehensive, long-term follow up.

show abstract

“…It is essential that survivors receive appropriate education and screening so that late effects can be recognized at their earliest, most treatable stage. A multidisciplinary approach is often necessary (4,8).…”

Section: Importance Of Long Term Surveillance/follow Upmentioning

confidence: 99%

Endocrine late effects in paediatric cancer survivors

Seneviratne

Silva

2012

Sri Lanka J. Diabetes Endocrinol. Metab.

View full text Add to dashboard Cite

Improved survival following childhood malignancy has led to increased recognition of a multitude of late adverse effects in long term survivors, which affect their quality of life. Endocrine complications are among the commonest late effects seen and include dysfunction of the hypothalamo pituitary axis leading to impaired growth, abnormal puberty or hypopituitarism, gonadal dysfunction and infertility, thyroid gland dysfunction and neoplasms, obesity, impaired glucose homeostasis and abnormal bone development. Long term follow up is needed for early recognition and timely intervention to minimise the effects of these complications.

show abstract

Comprehensive clinical follow-up of late effects in childhood cancer survivors shows the need for early and well-timed intervention

Abstract: The observation that over 50% of cancer survivors suffered from late effects during the short follow-up period and that a high frequency of endocrine late effects was present indicates the need for early and well-timed intervention of the survivors.

Cited by 46 publications

References 32 publications

Late effects and quality of life of childhood cancer survivors: Part 2. Impact of radiotherapy

Late effects and quality of life of childhood cancer survivors: Part 2. Impact of radiotherapy

Increasing and Worsening Late Effects in Childhood Cancer Survivors during Follow-up

Endocrine late effects in paediatric cancer survivors

Contact Info

Product

Resources

About