Low T cell diversity is associated with poor outcome in bladder cancer: a comprehensive longitudinal analysis of the T cell receptor repertoire
Asbjørn Kjær,
Nanna Kristjánsdóttir,
Randi Istrup Juul
et al.
Abstract:T cells are one of the primary effector cells in the endogenous defense against cancer, yet the clinical impact of their quantity, diversity, and dynamics remains underexplored. Here we investigated the T cell receptor (TCR) repertoire in patients with bladder cancer. In patients with localized muscle-invasive bladder cancer, low peripheral TCR diversity pre-treatment was associated with poor outcomes, especially when combined with low T cell fraction in circulation. These low-diversity repertoires were domina… Show more
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