Comprehensive cell biological investigation of cytochalasin B derivatives with distinct activities on the actin network
Mervic D. Kagho,
Katharina Schmidt,
Christopher Lambert
et al.
Abstract:In search of a more comprehensive structure activity relationship (SAR) regarding the inhibitory effect of cytochalasin B (CB) on actin polymerization, a virtual docking of CB onto monomeric actin was conducted. This led to the identification of potentially important functional groups of CB (i.e. the NH group of the isoindolone core (N-2), and the hydroxyl groups at C-7 and C-20) involved in interactions with the residual amino acids of the binding pocket of actin. Chemical modifications of CB at positions C-7… Show more
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