Comprehensive Cardiovascular Magnetic Resonance Assessment in Patients With Sarcoidosis and Preserved Left Ventricular Ejection Fraction

Greulich, Simon; Kitterer, Daniel; Latus, Joerg; Aguor, Eissa N. E.; Steubing, Hannah; Kaesemann, Philipp; Patrascu, Alexandru; Greiser, Andreas; Groeninger, Stefan; Mayr, Agnes; Braun, Niko; Alscher, M. Dominik; Sechtem, Udo; Mahrholdt, Heiko

doi:10.1161/circimaging.116.005022

Cited by 61 publications

(46 citation statements)

References 35 publications

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“…54 Recently, Greulich et al prospectively studied 61 sarcoid patients (with no symptoms or nonspecific symptoms and preserved LVEF) and 26 healthy volunteers with comprehensive CMR (LGE and mapping sequences). 69 LGE was present only in sarcoid patients. Sarcoid patients have higher median T1, lower postcontrast T1, expanded ECV, and higher T2 values.…”

Section: Echocardiographymentioning

confidence: 89%

“…However, 11 of the 27 LGE‐negative patients showed a T2 abnormality, and 7 of the 23 normal T2 patients were LGE‐positive, suggesting a complementary role of the two techniques for the detection of cardiac sarcoidosis . Recently, Greulich et al prospectively studied 61 sarcoid patients (with no symptoms or nonspecific symptoms and preserved LVEF) and 26 healthy volunteers with comprehensive CMR (LGE and mapping sequences) . LGE was present only in sarcoid patients.…”

Section: Echocardiographymentioning

confidence: 99%

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Noninvasive imaging in cardiac deposition diseases

Shah

Nucifora

Perry

et al. 2017

Magnetic Resonance Imaging

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Infiltrative cardiomyopathy represents a heterogeneous group of diseases of the heart tissue with similar phenotypic expression. The condition is rare, but can be easily mistaken for other more common conditions of the heart. The diagnosis of infiltrative cardiomyopathy is therefore challenging and has often required the use of invasive procedures in the past. In the last decade there have been great advances in non‐invasive cardiac imaging modalities like echocardiography, cardiovascular magnetic resonance and nuclear imaging. Although no single imaging modality abnormality on its own is pathognomic for infiltrative cardiomyopathy, a combination of these different modalities are synergistic, and can greatly aid in the clinical diagnosis. In this review, we describe these advancements in non‐invasive cardiac imaging modalities with a particular focus on cardiovascular magnetic resonance imaging. Level of Evidence: 1 Technical Efficacy: Stage 3 J. Magn. Reson. Imaging 2018;47:44–59.

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Section: Echocardiographymentioning

confidence: 89%

Section: Echocardiographymentioning

confidence: 99%

Noninvasive imaging in cardiac deposition diseases

Shah

Nucifora

Perry

et al. 2017

Magnetic Resonance Imaging

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show abstract

“…Only a few cases with viral myocarditis were reported to present transient hypertrabeculation . Greulich et al have recently demonstrated the potential utility of novel CMR mapping techniques to detect early myocardial damages in sarcoidosis, but it seems that this technique contains some more research issues needed to be solved such as histological validation . Thus, the integrated multi‐imaging modality approach, which we deployed in this special case, still helps in earlier recognition of cardiac sarcoidosis at present.…”

Section: Discussionmentioning

confidence: 99%

Cardiac sarcoidosis mimicking left ventricular noncompaction: An approach to acquired apical hypertrabeculation

et al. 2019

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A 65‐year‐old asymptomatic woman, who had been pathologically diagnosed with pulmonary sarcoidosis, was admitted for further evaluation of possible cardiac involvement. Her echocardiography demonstrated the development of apical hypertrabeculation that was not observed 5 years previously. Cardiac magnetic resonance imaging revealed late gadolinium enhancement in the same region. Gallium single photon‐missioned computed tomography/computed tomography revealed high uptake. Therefore, the diagnosis of active cardiac sarcoidosis was established, and subsequent treatment with corticosteroid was initiated. No study regarding acquired left ventricular hypertrabeculation associated with cardiac sarcoidosis has been reported. The integrated multi‐imaging modality approach helped in earlier recognition of cardiac sarcoidosis.

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“…Banypersad et al [49] showed ECV was independently predictive of mortality (HR, 4.41; 95% CI: 1.35-14.4) after adjusting for E/e' , EF, diastolic dysfunction grade and NT-proBNP, but not with native T1 data in light chain amyloidosis. Greulich et al [50] reported that sarcoid patients had a higher median native T1 (994 vs. 960 ms; CVIA p<0.001), lower post-T1 (491 vs. 526 ms; p=0.001), expanded extracellular volume (28 vs. 25%; p=0.001), and higher T2 values (52 vs. 49 ms; p<0.001) compared with controls. Thus, patients with sarcoidosis demonstrated higher T1 values, extracellular volume, and T2 values compared to healthy controls, with the most significant differences seen in native T1 and T2 data.…”

Section: Cardiac Amyloidosis and Sarcoidosismentioning

confidence: 99%

The Prognostic Role of T1 Mapping Sequences: Can T1 Mapping Parameters Have a Role in Risk Stratification?

Choi

Park

Kim

2017

Cardiovasc Imaging Asia

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Cardiovascular disease risk stratification and prognostication are very important for treatment planning. In addition, for a growing number of patients with overt symptomatic heart failure or asymptomatic but have structural heart disease, accurate risk stratification is essential. Conventional clinical cardiovascular risk factors, several biomarkers and echo-Doppler indexes are generally used to satisfy this need. However, non-invasive approaches to direct structural and tissue characterization of the myocardium have not produced satisfactory results. The recent development of the late gadolinium enhancement (LGE) imaging allows fibrosis or myocardial inflammation to be visualized. A growing body of evidence for LGEbased prognostication has been reported. However, not all patients with heart failure or at risk for it have been assessed with LGE. Moreover, the degree of diffuse fibrosis or inflammation cannot be easily quantified with LGE techniques. Recently, introduced T1 mapping-based quantification can provide the volume of extracellular space suggestive of the degree of diffuse tissue fibrosis or inflammation. Even without gadolinium contrast, native T1 values can provide quantitative information on myocardial tissue status. Here, we review current evidence for T1 mapping-based risk stratification and prognostication for various cardiac diseases that can lead to heart failure or lethal arrhythmic events.

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Comprehensive Cardiovascular Magnetic Resonance Assessment in Patients With Sarcoidosis and Preserved Left Ventricular Ejection Fraction

Cited by 61 publications

References 35 publications

Noninvasive imaging in cardiac deposition diseases

Noninvasive imaging in cardiac deposition diseases

Cardiac sarcoidosis mimicking left ventricular noncompaction: An approach to acquired apical hypertrabeculation

The Prognostic Role of T1 Mapping Sequences: Can T1 Mapping Parameters Have a Role in Risk Stratification?

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