Comprehensive Bioinformatics Analysis Reveals that N6-Methyladenosine (m6A) Methylation Reader HNRNPC Facilitates Progression of OSCC Through Promoting&amp;nbsp;Epithelial-Mesenchymal Transition(EMT)

Huang, Guangzhao; Wu, Qimeng; Zheng, Zenan; Shao, Ting-ru; Chen, Yue-chuan; Zeng, Weiseng

doi:10.2139/ssrn.3514633

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“…In gastric cancer, reduced m 6 A modification can promote gastric cancer malignancy by activating oncogenic signalling, and FTO acting as an oncogene can promote tumour growth [ 128 , 129 ]. Similarly, hnRNPC was identified as an independent prognostic biomarker in oral squamous cell carcinoma (OSCC) and the overexpression of hnRNPC facilitated the development of OSCC cells in vitro [ 130 ]. MALDI-TOF-MS revealed that the methylation level of miRNA methylation was significantly higher in PC compared with normal tissues, so evaluating miRNA methylation is a promising diagnostic strategy [ 131 ].…”

Section: Biological Function Of M 6 Amentioning

confidence: 99%

Insight into m ⁶ A methylation from occurrence to functions

Zhang

Yue

et al. 2020

Open Biol.

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RNA m 6 A methylation is a post-transcriptional modification that occurs at the nitrogen-6 position of adenine. This dynamically reversible modification is installed, removed and recognized by methyltransferases, demethylases and readers, respectively. This modification has been found in most eukaryotic mRNA, tRNA, rRNA and other non-coding RNA. Recent studies have revealed important regulatory functions of the m 6 A including effects on gene expression regulation, organism development and cancer development. In this review, we summarize the discovery and features of m 6 A, and briefly introduce the mammalian m 6 A writers, erasers and readers. Finally, we discuss progress in identifying additional functions of m 6 A and the outstanding questions about the regulatory effect of this widespread modification.

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