Comprehensive Assessment of Initial Adaptation of ESBL Positive ST131Escherichia colito Carbapenem Exposure
William C. Shropshire,
Xinhao Song,
Jordan Bremer
et al.
Abstract:BackgroundIt remains unclear how high-riskEscherichia colilineages, like sequence type (ST) 131, initially adapt to carbapenem exposure in their progression to becoming carbapenem resistant.MethodsCarbapenem mutation frequency was measured in multiple subclades of extended-spectrum β-lactamase (ESBL) positive ST131 clinical isolates using a fluctuation assay followed by whole genome sequencing (WGS) characterization. Genomic, transcriptomic, and porin analyses of ST131 C2/H30Rx isolate, MB1860, under prolonged… Show more
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