Comprehensive approach of donepezil and psychosocial interventions on cognitive function and quality of life for Alzheimer's disease: the Osaki-Tajiri Project

Meguro, Mitsue; Kasai, Mari; Akanuma, Kyoko; Ishii, Hiroshi; Yamaguchi, Satoshi; Meguro, Kenichi

doi:10.1093/ageing/afn107

Cited by 33 publications

(24 citation statements)

References 21 publications

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“…Recently, some studies suggested that psychosocial intervention, such as reality orientation, enhanced the effect of donepezil treatment alone [49][50][51]. In the coming years, significant development of combination therapies, including psychosocial intervention, will enable us to offer a more comprehensive approach to the treatment of patients with AD.…”

Section: Five-year Viewmentioning

confidence: 99%

Donepezil in the treatment of patients with Alzheimer’s disease

Tsuno¹

2009

Expert Review of Neurotherapeutics

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Alzheimer's disease (AD) is the most common cause of dementia and is characterized by an insidious onset and slow deterioration in cognition, activities of daily living (ADL), mood stability and social functioning. The cholinesterase inhibitors (ChEIs), developed based on the cholinergic hypothesis, are currently considered to be the best established treatment for AD, although the significant advances in the symptomatic pharmacotherapy of AD may be followed by disease-modification treatments. Donepezil is a mixed competitive and noncompetitive acetylcholinesterase inhibitor that shows a relative selectivity for acetylcholinesterase inhibitor compared with butyrylcholinesterase. In many clinical trials of donepezil, beneficial effects on standard measures of cognitive function, ADL and behavior have been shown in patients with mild, moderate or severe AD. Although the pharmacological and phamacokinetic profiles of the currently available ChEIs have notable differences that may affect efficacy, the clinical significance of these differences remains hypothetical in the absence of large, randomized trials that compare the ChEIs with each other.

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Section: Five-year Viewmentioning

confidence: 99%

Donepezil in the treatment of patients with Alzheimer’s disease

Tsuno¹

2009

Expert Review of Neurotherapeutics

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“…More recently, non-episodic memory interventions have also been applied in the form of strategy acquisition in this population (Rothi et al, 2009;Souchay, 2007). There has been some interest in the combination of psychosocial interventions along with cognitive enhancers (Meguro et al, 2008;Rothi et al, 2009;Rozzini et al, 2007). Additional reviews (De Werd, Boelen, Rikkert, & Kessels, 2013) focus on specific training methods.…”

Section: "Down" Extensions Of Ctmentioning

confidence: 99%

Perspectives on the Case of "Judith"

Hyer¹,

Brandon²

2015

PCSP

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Ward and Hogan's (2015) case of "Judith," a client with traumatic brain injury (TBI), highlights the emerging interactive features of effective psychotherapy melding core elements of the art and science of a tried and true psychotherapy practice (non-directive, client-centered therapy) with cognitive training (CT), including executive functioning training. In our commentary we summarize the facts of the case and then view it from four perspectives: the role of additional assessment, psychiatric diagnoses, the role of CT, and the Hyer Model. The latter is our own model that highlights a comprehensive, systematic, holistic, individually tailed approach to the treatment process when both psychological distress and/or dysfunction are combined with cognitive deficit factors. We suggest that the Hyer Model helps to formalize and systematize the approach taken by Ward and Hogan in their case study of Judith.

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“…Psychosocial intervention is important for improvement of the QOL and maximum induction of drug effects. Thus, it is desirable that the intervention should be performed in combination with drug therapy [6,7]. Therefore, collaboration between medical treatment and nursing care is essential for dementia treatment.…”

Section: Introductionmentioning

confidence: 99%

Current Healthcare System for Community Residents with Dementia: A Questionnaire Survey for Dispensing Pharmacies, Home Care Support Offices, and Visiting Care Support Offices

Takahashi¹,

Aoki²,

Sato³

et al. 2017

J Community Med Health Educ

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Background: Since the number of dementia specialists is limited, dispensing pharmacies provide early detection of dementia patients in the community and drug management instructions, and care managers, who contribute to the collaboration between medical treatment and nursing care, play an important role. This investigation was performed with the aim of clarifying the awareness of dementia medication and actual psychosocial intervention to prepare materials for discussions on a system to provide effective care.

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Comprehensive approach of donepezil and psychosocial interventions on cognitive function and quality of life for Alzheimer's disease: the Osaki-Tajiri Project

Cited by 33 publications

References 21 publications

Donepezil in the treatment of patients with Alzheimer’s disease

Donepezil in the treatment of patients with Alzheimer’s disease

Perspectives on the Case of "Judith"

Current Healthcare System for Community Residents with Dementia: A Questionnaire Survey for Dispensing Pharmacies, Home Care Support Offices, and Visiting Care Support Offices

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