Comprehensive analysis to long non-coding RNA-mediated high expression of GNG5 correlates with better prognosis and tumor immune infiltration of colon carcinoma

Abstract

Background Colorectal cancer is the third most common cancer and the fourth leading cause of cancer deaths, and prognosis is poor and the majority of patients are diagnosed with locally advanced or metastatic disease.Increasing evidence suggests GNG5 play key roles in several types of human cancer, The key gating mechanisms in colorectal cancer remails unkown. Methods In this study, Pan-cancer analyses have been performed for GNG5’s expressionon and prognosis using The Cancer Genome Atlas (TCGA) and The Genotype-Tissue Expression (GTEx) data and found that GNG5 might be activated oncogenes in CRC.Noncoding RNAs (ncRNAs) play increasingly appreciated gene-regulatory roles and long noncoding RNAs (lncRNAs) contributing to GNG5 overexpression were identified by a combination in silico computational analyses, we determine candidate regulators controlling colon carcinoma survival analysis and correlation analysis. Results The SNHG4/DRAIC-let-7c-5p axis was identifiedas the most potential upstream lncRNA-related pathway of GNG5 in CRC.GNG5 level was significantly positively correlated with tumor immune cell infiltration, immune cell biomarkers and immune checkpoint expression. Conclusions Our findings elucidated that lncRNAs-mediated downregulation of GNG5 correlated with better prognosis and tumor immune infiltration in colorectal cancer.