Comprehensive analysis of the renin–angiotensin gene polymorphisms with relation to hypertension in the Japanese

Kato, Norihiro; Sugiyama, Takao; Morita, Hiroyuki; Kurihara, Hiroki; Furukawa, Taiji; Isshiki, Takaaki; Sato, Tomohide; Yamori, Yukio; Yazaki, Yoshio

doi:10.1097/00004872-200018080-00006

Cited by 57 publications

(47 citation statements)

References 35 publications

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“…In keeping with the results of earlier studies, the associations of the CYP11B2 C-344T polymorphism with BP remain inconclusive. [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] In addition, our results were not consistent with previous reports indicating that BP elevation was sensitive in elderly subjects with the TT genotype. 20,21 Furthermore, we suggested that the association of the CC genotype with CRP was consistent with previous reports describing the association of the genotype with cardiac structures and atherosclerosis as discussed above, 17,34 whereas some apparent contradictory associations between the genotype and atherosclerosis, including cardiac structure and coronary artery diseases, have been shown in previous studies.…”

Section: Discussioncontrasting

confidence: 99%

“…Allele and genotype frequencies were analyzed using the genecounting method, and the Hardy-Weinberg equilibrium, checked by the w 2 -test, was considered to be maintained as described previously. 13,17 First, statistical significance was determined by one-way ANOVA (analysis of variance) or by the w 2 -test. In the case of statistically significant relations, the Bonferroni analysis was applied to assess the relationship between categories.…”

Section: Discussionmentioning

confidence: 99%

“…3 An overview of published studies suggests a higher frequency of hypertension or increase in blood pressure (BP) in subjects with the T allele or TT genotype as compared with that in subjects with the C allele or CC genotype, [4][5][6][7][8][9][10] although several studies have reported the opposite association 11,12 or the absence of any association. [13][14][15][16][17][18][19] Thus, the associations remain controversial. Recently, two interesting studies have suggested a key indicator that may resolve the association.…”

Section: Introductionmentioning

confidence: 99%

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Aldosterone synthase (CYP11B2) C-344T polymorphism affects the association of age-related changes of the serum C-reactive protein

et al. 2010

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Aldosterone participates in vascular and myocardial inflammation either directly or indirectly through blood pressure (BP). Aldosterone synthase (CYP11B2) C-344T polymorphism may influence the severity of systemic inflammation. A total of 398 Japanese Americans (152 men and 246 women, age 19-92 years) from the Hawaii-Los Angeles-Hiroshima study were enrolled. BP and serum levels of C-reactive protein (CRP) were measured, and the CYP11B2 C-344T polymorphism, rs1799998, was determined. No influence of the polymorphism on baseline characteristics such as systolic, diastolic and mean BP, pulse pressure or serum CRP levels was observed. In all genotypes, systolic BP showed a significantly positive correlation with age (TT (n¼178): r¼0.283, Po0.001; TC (n¼164): r¼0.213, P¼0.006; and CC (n¼56): r¼0.289, P¼0.031). However, the regression coefficients of systolic BP with age were not different across genotypes. According to the results of univariate and multivariate analyses with adjustment for BP, the serum CRP level increased with age only in subjects with the CC genotype (P¼0.027 and P¼0.004, respectively), and elevation of serum CRP was mainly observed in the elderly population (aged X60 years). Moreover, the regression coefficient of CRP levels with age was significantly steeper in subjects with the CC genotype than in those with the TC or TT genotype (P¼0.028). The CC genotype of the CYP11B2 C-344T polymorphism was associated with an age-dependent increase in the serum CRP level independent of BP, and may contribute to a cardiovascular phenotype by promoting vascular inflammation.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Aldosterone synthase (CYP11B2) C-344T polymorphism affects the association of age-related changes of the serum C-reactive protein

et al. 2010

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“…On the other hand, Kato et al 18 have performed a case-control study in which they failed to find any relation between the gene polymorphisms of the renin-angiotensin-aldosterone system and EH. In the subanalysis of their study, similar criteria to our study were applied to select the normotensive and hypertensive subjects.…”

Section: Discussionmentioning

confidence: 99%

Positive association of CYP11B2 gene polymorphism with genetic predisposition to essential hypertension

Tsukada¹,

Ishimitsu²,

Teranishi³

et al. 2002

J Hum Hypertens

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Predispositions to essential hypertension and cardiovascular diseases are possibly associated with gene polymorphisms of the renin-angiotensin system. Gene polymorphisms of angiotensinogen and angiotensinconverting enzyme genes have been suggested to be risk factors for hypertension and myocardial infarction. Concerning the polymorphism of aldosterone synthase (CYP11B2) gene, earlier studies have shown inconsistent results in terms of its relation to hypertension. In the present case-control study, we investigated the association of À344T/C polymorphism in the promoter region of human CYP11B2 gene with genetic predisposition to hypertension. The genotype of À344T/C polymorphism was determined in essential hypertension subjects (n ¼ 250) and normotensive subjects (n ¼ 221). The distributions of three genotypes (TT, TC, and CC) were significantly different between the hypertensive and the normotensive groups (v 2 ¼ 9.61, P ¼ 0.008). Namely, the frequency of C allele was higher in the hypertensive patients than in the normotensive subjects (34.2 vs 26.5%, P ¼ 0.010). Our data suggest that the À344C allele of CYP11B2 gene polymorphism is associated with the genetic predisposition to develop essential hypertension.

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“…[3][4][5][6][7][8] However, the overall results are inconsistent. [9][10][11][12][13][14] Most of these studies used a very small limited number of single-nucleotide polymorphisms (SNPs) in the AGT gene (i.e., 1 or 2). The main drawback to this approach is that, if these SNPs are not causal SNPs or are not in strong linkage disequilibrium (LD) with causal SNPs, the power to detect association will be limited.…”

Section: Introductionmentioning

confidence: 99%

The effect of genetic variation in angiotensinogen on serum levels and blood pressure: a comparison of Nigerians and US blacks

Fejerman

Adeyemo

et al. 2006

J Hum Hypertens

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Molecular variants of angiotensinogen (AGT) have been associated with AGT level and hypertension (HT). However, results from reported studies vary considerably between-and within-studied populations. We performed association analysis of AGT gene variants with AGT levels and HT in samples of African descent families, including 595 Nigerians and 901 African Americans. We evaluated association using haplotypes defined by a set of single-nucleotide polymorphisms selected from a previous detailed study of the gene haplotype structure. In the sample of Nigerian families, AGT haplotype H1 was associated with high plasma level. Results were not significant for blood pressure (BP) or HT. For the African-American population, we found significant association between low plasma AGT level and haplotype H7. Furthermore, we found weak associations of H1 with hypertensive status and H7 with low systolic BP. However, no significant association between H1 and high plasma level was found. We conclude that the two distantly related haplotypes, H1 and H7, are associated, but have opposite effects on the phenotypes in two populations of African origin.

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Comprehensive analysis of the renin–angiotensin gene polymorphisms with relation to hypertension in the Japanese

Cited by 57 publications

References 35 publications

Aldosterone synthase (CYP11B2) C-344T polymorphism affects the association of age-related changes of the serum C-reactive protein

Aldosterone synthase (CYP11B2) C-344T polymorphism affects the association of age-related changes of the serum C-reactive protein

Positive association of CYP11B2 gene polymorphism with genetic predisposition to essential hypertension

The effect of genetic variation in angiotensinogen on serum levels and blood pressure: a comparison of Nigerians and US blacks

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