Comprehensive Analysis of the Long Noncoding RNA‑associated Competitive Endogenous RNA Network in the Osteogenic Differentiation of Periodontal Ligament Stem Cells
Abstract:BACKGROUDThe mechanism implicated in the osteoblast differentiation of human periodontal ligament stem cells (PDLSCs) has been investigated for years. Previous genomics data analyses showed that long noncoding RNA (lncRNA), microRNA (miRNA) and messenger RNA (mRNA) have significant expression differences between induced and control human PDLSCs. Competing for endogenous RNAs (ceRNA), as a widely studied mechanism in regenerative medicine, while rarely reported in periodontal regeneration. The key lncRNAs and t… Show more
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