Comprehensive Analysis of the Expression and Prognosis for E2Fs in Human Cervical Cancer

Abstract

Background: Accumulating evidence was found that E2Fs are a family of transcription factors that are aberrantly expressed or multi-activated in malignant tumors and are found in a variety of tumorigenesis. However, the expression pattern and exact role of E2Fs in cervical cancer (CC) tumorigenesis and progression have not been elucidated.Methods: In the study arrangement, we examined the expression and prognostic value of E2Fs in CC patients using multiple databases, including ONCOMINE, GEPIA, cBioPortal, Metascape, and Kaplan-Meier mapper.Results: E2F1/2/3/8 is upregulated in CC patients, with E2F1 mRNA levels upregulated with better OS correlation. E2F3/8 has an even worse RFS difference and could presumably be used as a CC therapeutic target. Conclusion: These results suggest that E2F1/2/3/8 can exist as a marker for CC. However, more experimental results are needed to confirm this inference.