Comprehensive Analysis of Temozolomide Treatment for Patients with Glioma

Yang, Wen-Bing; Xing, Bian-Zhi; Liang, Hua

doi:10.7314/apjcp.2014.15.19.8405

Cited by 6 publications

(5 citation statements)

References 27 publications

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“…Although some studies have suggested that after lumbar decompression, physical therapy intervention does not significantly affect clinical outcomes, as measured by patient-reported outcomes and surgical outcomes [24,25], numerous approaches aimed at improving nursing quality, such as brain storming, world café, and management by objectives, have been created since the World Health Organization has defined quality nursing as a patient-oriented, fair, convenient, effective, highly efficient, safe and acceptable model of nursing [26]. Studies have shown that personalized nursing that involves the application of a scientific, systemic and standardized nursing program and plan is effective for postoperative rehabilitation [27,28]. In addition, intimate and comprehensive nursing also contributes to communication and relationships between patients and nurses, which is beneficial for improving the quality of nursing and the outcome of surgery [29][30][31].…”

Section: Discussionmentioning

confidence: 99%

The impact of nursing interventions on the rehabilitation outcome of patients after lumbar spine surgery

Liang,

Wang,

Song

et al. 2024

BMC Musculoskelet Disord

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Background This study aimed to investigate the impact of nursing interventions on the rehabilitation outcomes of patients after lumbar spine surgery and to provide effective references for future postoperative care for patients undergoing lumbar spine surgery. Methods The study included two groups: a control group receiving routine care and an observation group receiving additional comprehensive nursing care. The comprehensive care encompassed postoperative rehabilitation, pain, psychological, dietary management, and discharge planning. The Visual Analogue Scale (VAS), Oswestry Disability Index (ODI), Short-Form 36 (SF-36) Health Survey, self-rating depression scale (SDS) and self-rating anxiety scale(SAS) were used to assess physiological and psychological recovery. Blood albumin, haemoglobin, neutrophil counts, white blood cell counts, red blood cell counts, inflammatory markers (IL-6, IL-10, and IFN-γ) were measured, and the incidence of postoperative adverse reactions was also recorded. Results Patients in the observation group exhibited significantly improved VAS, ODI, SF-36, SDS and SAS scores assessments post-intervention compared to the control group (P < 0.05). Moreover, levels of IL-6, IL-10, and IFN-γ were more favorable in the observation group post-intervention (P < 0.05), indicating a reduction in inflammatory response. There was no significant difference in the incidence of postoperative adverse reactions between the groups (P > 0.05), suggesting that the comprehensive nursing interventions did not increase the risk of adverse effects. Conclusion Comprehensive nursing interventions have a significant impact on the postoperative recovery outcomes of patients with LSS, alleviating pain, reducing inflammation levels, and improving the overall quality of patient recovery without increasing the patient burden. Therefore, in clinical practice, it is important to focus on comprehensive nursing interventions for patients with LSS to improve their recovery outcomes and quality of life.

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Section: Discussionmentioning

confidence: 99%

The impact of nursing interventions on the rehabilitation outcome of patients after lumbar spine surgery

Liang,

Wang,

Song

et al. 2024

BMC Musculoskelet Disord

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“…Although surgical resection, radiotherapy, chemotherapy, and other comprehensive treatment modalities were implemented, the majority of patients exhibited an unfavorable prognosis. Consequently, the exploration of novel biomarkers for early detection has emerged as a pivotal endeavor to enhance the diagnosis and management of glioma [10][11][12].…”

Section: Discussionmentioning

confidence: 99%

has-miR-134-5p inhibits the proliferation and migration of glioma cells by regulating the BDNF/ERK signaling pathway

Guo,

An,

Hong

2024

Aging

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Our research investigated the effects of hsa-miR-134-5p on glioma progression, focusing on its interaction with the BDNF/ERK signaling pathway. U251 and U87 cell lines were analyzed post-transfection with hsa-miR-134-5p mimics and inhibitors, confirming the miRNA’s binding to BDNF using dual luciferase assays. Q-PCR was employed to measure expression changes, revealing that hsa-miR-134-5p markedly inhibited glioma cell proliferation, migration, and invasion, as evidenced by CCK8, monoclonal formation, and Transwell assays. Scratch tests and Western blotting demonstrated hsa-miR-134-5p’s modulation of the BDNF/ERK pathway and associated decrease in MMP2/9 protein levels. Flow cytometry suggested that hsa-miR-134-5p might also block the G0/S phase transition. In vivo studies using nude mice corroborated the tumor-suppressing effects of hsa-miR-134-5p, which were negated by elevated BDNF levels. Comparative protein analysis across groups confirmed the pathway’s significance in tumorigenesis. Our findings identify hsa-miR-134-5p as a key molecule impeding glioma cell growth by curtailing the BDNF/ERK pathway, with the reversal by BDNF upregulation pointing to the potential of therapeutically exploiting the hsa-miR-134-5p/BDNF axis in glioma care.

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“…It does realize joint nursing, and it optimizes communication and promotes the relationship between patients and nurses so that the quality of nursing is improved[ 15 , 16 ]. In comprehensive nursing, effective personalized nursing can be provided to patients by using a scientific, systemic and standardized nursing program and nursing plan[ 17 , 18 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of comprehensive nursing on postoperative complications, mental status and quality of life in patients with glioma

Dong¹,

Zhang²,

Deng³

et al. 2022

WJCC

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BACKGROUND The complexity and refractory of brain glioma requires treatment that should involve a multidisciplinary approach to improve quality of care and fulfill patients’ needs. AIM To explore the effects of comprehensive nursing on postoperative complications, psychological state and quality of life in patients with brain glioma. METHODS A total of 106 patients with confirmed brain gliomas admitted to Nanchong Central Hospital between January 2019 and May 2021 were selected by random sampling. They were categorized into an observation group and a control group using a random number table with 53 patients in each group. Patients in the observation group were given comprehensive nursing in addition to conventional nursing and patients in the control group were given conventional nursing. The overall incidence of postoperative complications including limb dysfunction, high fever and epilepsy was compared between the two groups. The mental status was evaluated in the two groups before and after intervention using self-rating anxiety scale (SAS) and self-rating depression scale (SDS). Quality of life was assessed and compared using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire between the two groups before and after the intervention. RESULTS After intervention, the overall incidence of postoperative complications was significantly lower in the observation group (7.55%) than that in the control group (20.75%) ( P < 0.05). Before intervention, there was no significant difference in SAS and SDS scores between the two groups ( P > 0.05). However, after intervention, scores of SAS and SDS decreased in the two groups compared with those before intervention, and the scores of SAS and SDS were lower in the observation group than in the control group (all P < 0.05). There was no significant difference in quality of life between the two groups before the intervention ( P > 0.05). In contrast, quality of life increased in the two groups compared with those before intervention, and it was higher in the observation group than in the control group ( P < 0.05). CONCLUSION Comprehensive nursing can reduce the incidence of postoperative complications, improve the psychological state of anxiety and depression and improve quality of life in patients with brain glioma.

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Comprehensive Analysis of Temozolomide Treatment for Patients with Glioma

Cited by 6 publications

References 27 publications

The impact of nursing interventions on the rehabilitation outcome of patients after lumbar spine surgery

The impact of nursing interventions on the rehabilitation outcome of patients after lumbar spine surgery

has-miR-134-5p inhibits the proliferation and migration of glioma cells by regulating the BDNF/ERK signaling pathway

Effects of comprehensive nursing on postoperative complications, mental status and quality of life in patients with glioma

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