Comprehensive Analysis of Severe Viral Infections of Respiratory Tract admitted to PICUs during the Winter Season in Turkey

Abstract

Objectives To analyze the course of seasonal viral infections of respiratory tract in patients hospitalized in pediatric intensive care units (PICU) of 16 centers in Turkey. Materials and methods It is a retrospective, observational, and multicenter study conducted in 16 tertiary PICUs in Turkey includes a total of 302 children with viral cause in the nasal swab which required PICU admission with no interventions. Results Median age of patients was 12 months. Respiratory syncytial virus (RSV) was more common in patients over one year of age whereas influenza, human Bocavirus in patients above a year of age was more common ( p <0.05). Clinical presentations influencing mortality were neurologic symptoms, tachycardia, hypoxia, hypotension, elevated lactate, and acidosis. The critical pH value related with mortality was ≤7.10, and critical PCO 2 ≥60 mm Hg. Conclusion Our findings demonstrate that patients with neurological symptoms, tachycardia, hypoxia, hypotension, acidosis, impaired liver, and renal function at the time of admission exhibit more severe mortal progressions. Presence of acidosis and multiorgan failure was found to be predictor for mortality. Knowledge of clinical presentation and age-related variations among seasonal viruses may give a clue about severe course and prognosis. By presenting the analyzed data of 302 PICU admissions, current study reveals severity of viral respiratory tract infections and release tips for handling them. How to cite this article Kockuzu E, Bayrakcı B, Kesici S, Cıtak A, Karapınar K, Emeksiz S, et al. Comprehensive Analysis of Severe Viral Infections of Respiratory Tract admitted to PICUs During the Winter Season in Turkey. Indian J Crit Care Med 2019;23(6):263–269.

Identifying cerebral microstructural changes in patients with COVID-19 using MRI: A systematic review

“…Neurological complications affecting the central nervous system (CNS) have been reported in patients who are infected by respiratory viruses such as influenza virus,[ 5 6 7 ] respiratory syncytial virus,[ 8 9 10 ] parainfluenza virus,[ 11 ] metapneumovirus,[ 12 13 ] rhinovirus,[ 11 14 ] coronaviruses,[ 3 15 16 17 18 ] adenoviruses,[ 19 ] and bocaviruses. [ 20 21 ] Even though the predominant clinical manifestations of SARS-CoV-2 were found in the respiratory system, neurological manifestations such as headache, anosmia, seizure, stroke, encephalitis, and meningitis are now significantly recognized. [ 3 4 16 17 18 22 23 24 25 26 27 28 29 30 ] SARS-CoV-1 and SARS-CoV-2 assign the same receptor, angiotensin-converted enzyme 2, which can be found in the CNS and mediate the disease process.…”