Comprehensive Analysis of Pyroptosis-Related Long Noncoding RNA Immune Infiltration and Prediction of Prognosis in Patients with Colon Cancer

Abstract

Colon cancer (CC) is one of the most prevalent malignant tumours of the alimentary canal. It is unclear whether pyroptosis-related lncRNA expression is correlated with CC prognosis. We discovered 20 pyroptosis-related lncRNAs that were expressed differently in CC and normal colon tissues in our investigation. Based on differentially expressed genes (DEGs), we grouped all CC patients into two categories (Clusters 1 and 2). Cluster 1 was shown to be connected with a higher overall survival rate, upregulated expression of immune checkpoints, higher immunoscores, higher estimated scores, and immune cell infiltration. Using data from the Cancer Genome Atlas (TCGA), to create a multigene signature, the predictive significance of each lncRNA linked with pyroptosis for survival was assessed. A 9-lncRNA signature was established using the least absolute shrinkage and selection operator (LASSO) Cox regression method, and all CC patients in the TCGA cohort were classified into low-risk or high-risk groups. The low-risk CC patients had a much greater chance of survival than those in the high-risk group. The risk score is an independent prognostic indicator for predicting survival. In addition, risk characteristics are linked to immune characteristics. In summary, pyroptosis-related lncRNAs can be used to predict CC prognosis and participate in tumour immunity.

A Necroptosis-Related lncRNA Signature Predicts Prognosis and Indicates the Immune Microenvironment in Soft Tissue Sarcomas

“…More importantly, previous studies have confirmed that the NRlncRNA signature also can be used to predict the prognosis of tumors. For instance, the NRlncRNAs have vital functions in Colon Cancer, and the signature composed of NRlncRNAs can predict the prognosis of Colon Cancer (CC) and be used to customize CC treatment in the future ( Liu et al, 2022 ). However, the relationship between NRlncRNAs and STS is still unknown.…”

Qualification of Necroptosis-Related lncRNA to Forecast the Treatment Outcome, Immune Response, and Therapeutic Effect of Kidney Renal Clear Cell Carcinoma

“…For instance, Luo et al studied the association of lncRNAs with stomach adenocarcinoma, focusing on a twelve NRL signature which included LASTR, one of the lncRNAs identified in this work as NRL for KIRC [ 40 ]. Liu et al studied lncRNAs in colon cancer and identified MYOSLID as associated to pyroptosis, linking this lncRNA to regulation of SKP1 expression via MIR-589-5p and to the miR-29c-3p-mcl-1 axis [ 41 ]. The function of lncRNAs in sequestering and inactivating one or more miRNA species was studied also in the necroptosis response in HCC [ 42 ].…”

Construction and Validation of Pyroptosis-Related lncRNA Prediction Model for Colon Adenocarcinoma and Immune Infiltration Analysis

“…Several recent studies have proposed prognostic models for COAD [22][23][24]. However, the studies' predictive performances have not been validated in COAD, and the differences in immune infiltrating cells and immune checkpoint blockade-, immune checkpoint-, and m6A-related genes between the high and low risks of the prediction model were not analyzed.…”