Comprehensive analysis of partial epithelial mesenchymal transition‐related genes in hepatocellular carcinoma

Yu, Lei; Yan, Wei; Lin, Zhuoying; Liu, Jingmei; Tian, Dean; Han, Ping

doi:10.1111/jcmm.16099

Cited by 25 publications

(22 citation statements)

References 50 publications

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“…A total of 298 potential lncRNA candidates with miRNA-29c-binding sites were predicted ( Supplementary Table S2 ). Considering the ceRNA hypothesis that the relevance between lncRNA and miRNA was negative while the relevance between lncRNA and mRNA was positive ( Lei et al, 2021 ), we firstly performed a correlation analysis between miRNA-29c and the 298 lncRNAs in 372 STAD samples of TCGA databases. Among them, only 33 lncRNA–miRNA pairs were inversely related ( Figure 4A ).…”

Section: Resultsmentioning

confidence: 99%

“…We also predicted the upstream lncRNAs of miRNA-29c in gastric cancer. Based on the ceRNA hypothesis that the relevance between lncRNA and miRNA was negative, while the relevance between lncRNA and mRNA was positive ( Zhou et al, 2020 ; Lei et al, 2021 ), nine lncRNAs were considered for following analyses. Further expression analysis and survival analysis showed that only HIF1A-AS2 and RP11-366L20.2 fulfilled our criteria that they are highly expressed in tumors and that their high expression indicates a worse prognosis.…”

Section: Discussionmentioning

confidence: 99%

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lncRNA/miR-29c-Mediated High Expression of LOX Can Influence the Immune Status and Chemosensitivity and Can Forecast the Poor Prognosis of Gastric Cancer

Nai

Zeng

et al. 2022

Front. Cell Dev. Biol.

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Gastric carcinoma is the fourth most prevalent cause of cancer-related deaths worldwide because of dismal prognosis and few therapeutic options. Accumulated studies have indicated that targeting lysyl oxidase (LOX) family members may serve as an anticancer strategy. Nevertheless, the specific mechanisms of LOX in stomach carcinoma are still unclear. In this study, we demonstrated that LOX is significantly different in 13 types of cancers and may act as a potential therapeutic target, especially in stomach carcinoma. Moreover, overexpression of LOX in gastric carcinoma was validated by multiple databases and contributed to the poor overall survival (OS), progression-free survival (PFS) and post-progression survival (PPS) of stomach adenocarcinoma (STAD) patients. Next, based on the ceRNA hypothesis, the HIF1A-AS2/RP11-366L20.2-miR-29c axis was characterized as the upstream regulatory mechanism of LOX gene overexpression in gastric cancer by combining correlation analysis, expression analysis, and survival analysis. Finally, we illustrated that LOX gene overexpression leads to dismal prognosis of gastric cancer, perhaps through promoting M2 macrophage polarization and tumor immune escape and enhancing drug resistance of tumor cells to chemotherapeutic drugs. Our research demonstrate that LOX may be potentially applied as a novel prognostic marker and targeting inhibition of LOX holds promise as a treatment strategy for gastric cancer.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

lncRNA/miR-29c-Mediated High Expression of LOX Can Influence the Immune Status and Chemosensitivity and Can Forecast the Poor Prognosis of Gastric Cancer

Nai

Zeng

et al. 2022

Front. Cell Dev. Biol.

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“…Moreover, partial EMT (p-EMT) can drive distinct migratory properties and enhance the epithelialmesenchymal plasticity of cancer cells and cell fate plasticity. 67 Yu et al 68 suggested that key p-EMT-related genes (P4HA2, ITGA5, MMP9, MT1X, and SPP1) could serve as prognostic biomarkers and therapeutic targets for HCC. Recent studies have demonstrated the role of exosomes in EMT progression in different types of cancer, including HCC.…”

Section: Role Of Exosomes In the Formation Of Hcc Microenvironmentmentioning

confidence: 99%

Current perspectives on exosomes in the diagnosis and treatment of hepatocellular carcinoma (review)

Xue

Han

Liu

et al. 2021

Cancer Biology & Therapy

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The prognosis of hepatocellular carcinoma (HCC), a malignant tumor, is poor. Tumor recurrence and metastasis are the major challenges for the treatment of HCC. Various studies have demonstrated that exosomes, which are loaded with various biomolecules including nucleic acids, lipids, and proteins are involved in the recurrence and metastasis of HCC. Additionally, exosomes mediate various biological processes, such as immune response, cell apoptosis, angiogenesis, thrombosis, autophagy, and intercellular signal transduction. In cancer, exosomes regulate cancer cell differentiation, development, and drug resistance. Circular RNAs, microRNAs, and proteins in the exosomes can serve as early diagnostic and prognostic markers for HCC. As exosomes are characterized by low immunogenicity and high stability in the tissues and circulation, they can be used to deliver the drugs in cancer therapies.

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“…EMT-associated gene models have been developed to predict HCC prognosis [ 4 , 12 ]. However, the functions and prognostic value of EMT-related lncRNAs have not been systematically investigated.…”

Section: Introductionmentioning

confidence: 99%

Identification of an EMT-related lncRNA signature and LINC01116 as an immune-related oncogene in hepatocellular carcinoma

Tao

Zhang

Yuan

et al. 2022

Aging

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Background: Epithelial-mesenchymal transition (EMT) plays a critical role in the recurrence and metastasis of hepatocellular carcinoma (HCC). Some long noncoding (lnc)RNAs are involved in this process through the regulation of EMT-related transcription factors. Methods: In this study, we established a novel EMT-related lncRNA signature in HCC and identified hub lncRNAs that can serve as potential therapeutic targets. Differentially expressed lncRNAs were identified by screening HCC patient data from The Cancer Genome Atlas, and a correlation analysis was performed to identify those associated with EMT. The EMT-related lncRNA signature was established by univariate, least absolute shrinkage and selection operator, and multivariate Cox regression analyses. After verifying the prognostic accuracy of the signature, its relationships to immune cell infiltration and immune checkpoint targets were explored. LINC01116 was identified as a hub lncRNA and its role in HCC was investigated in vitro and in vivo. Results: A 5-lncRNA signature was developed for HCC and its prognostic accuracy was assessed by survival, time-dependent receiver operating characteristic curve, clinical correlation, and Cox regression analyses. The correlation analysis showed that the lncRNA signature was closely related to immune cell infiltration and 10 immune checkpoint targets and also predicted the prognosis of HCC patients with high accuracy. In vitro and in vivo experiments revealed that LINC01116 stimulated cell proliferation, cell cycle progression, and tumor metastasis. We also found that LINC01116 was closely related to immune regulation. Conclusions: These results demonstrate that LINC01116 is an immune-related oncogene that is associated with both EMT and immune regulation in HCC. Moreover, the EMT-related lncRNA signature that includes LINC01116 can guide risk stratification and clinical decision-making in HCC management.

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Comprehensive analysis of partial epithelial mesenchymal transition‐related genes in hepatocellular carcinoma

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 25 publications

References 50 publications

lncRNA/miR-29c-Mediated High Expression of LOX Can Influence the Immune Status and Chemosensitivity and Can Forecast the Poor Prognosis of Gastric Cancer

lncRNA/miR-29c-Mediated High Expression of LOX Can Influence the Immune Status and Chemosensitivity and Can Forecast the Poor Prognosis of Gastric Cancer

Current perspectives on exosomes in the diagnosis and treatment of hepatocellular carcinoma (review)

Identification of an EMT-related lncRNA signature and LINC01116 as an immune-related oncogene in hepatocellular carcinoma

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