Comprehensive analysis of oral administration of Vitamin E on the early stage of Trypanosoma brucei brucei infection

Ojo, Rotimi Johnson; Enoch, Gideon Agyiye; Adeh, Faratu Saleh; Fompun, Luret Carmen; Bitrus, Blessing Yohanna; Kugama, M. A.

doi:10.1007/s12639-020-01322-5

Cited by 4 publications

(2 citation statements)

References 48 publications

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“…T.b.r infection resulted in a generalised decrease in serum levels of sodium, potassium and chloride ions signifying metabolic acidosis, in contrast to prior findings by Karaye et al [ 86 ] in Trypanosoma congolense and Trypanosoma brucei infected red Sokoto bucks. However, the findings are consistent with those of Ojo et al [ 87 ] in Trypanosoma brucei brucei infected rats. Both MelB and GB when administered separately or when co-administered, significantly normalized K, Na and Cl levels in serum.…”

Section: Discussionsupporting

confidence: 92%

Ginkgo biloba attenuated detrimental inflammatory and oxidative events due to Trypanosoma brucei rhodesiense in mice treated with melarsoprol

Wendo,

Mbaria,

Nyariki

et al. 2024

PLoS Negl Trop Dis

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Background The severe late stage Human African Trypanosomiasis (HAT) caused by Trypanosoma brucei rhodesiense (T.b.r) is characterized by damage to the blood brain barrier, severe brain inflammation, oxidative stress and organ damage. Melarsoprol (MelB) is currently the only treatment available for this disease. MelB use is limited by its lethal neurotoxicity due to post-treatment reactive encephalopathy. This study sought to assess the potential of Ginkgo biloba (GB), a potent anti-inflammatory and antioxidant, to protect the integrity of the blood brain barrier and ameliorate detrimental inflammatory and oxidative events due to T.b.r in mice treated with MelB. Methodology Group one constituted the control; group two was infected with T.b.r; group three was infected with T.b.r and treated with 2.2 mg/kg melarsoprol for 10 days; group four was infected with T.b.r and administered with GB 80 mg/kg for 30 days; group five was given GB 80mg/kg for two weeks before infection with T.b.r, and continued thereafter and group six was infected with T.b.r, administered with GB and treated with MelB. Results Co-administration of MelB and GB improved the survival rate of infected mice. When administered separately, MelB and GB protected the integrity of the blood brain barrier and improved neurological function in infected mice. Furthermore, the administration of MelB and GB prevented T.b.r-induced microcytic hypochromic anaemia and thrombocytopenia, as well as T.b.r-driven downregulation of total WBCs. Glutathione analysis showed that co-administration of MelB and GB prevented T.b.r-induced oxidative stress in the brain, spleen, heart and lungs. Notably, GB averted peroxidation and oxidant damage by ameliorating T.b.r and MelB-driven elevation of malondialdehyde (MDA) in the brain, kidney and liver. In fact, the co-administered group for the liver, registered the lowest MDA levels for infected mice. T.b.r-driven elevation of serum TNF-α, IFN-γ, uric acid and urea was abrogated by MelB and GB. Co-administration of MelB and GB was most effective in stabilizing TNFα levels. GB attenuated T.b.r and MelB-driven up-regulation of nitrite. Conclusion Utilization of GB as an adjuvant therapy may ameliorate detrimental effects caused by T.b.r infection and MelB toxicity during late stage HAT.

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Section: Discussionsupporting

confidence: 92%

Ginkgo biloba attenuated detrimental inflammatory and oxidative events due to Trypanosoma brucei rhodesiense in mice treated with melarsoprol

Wendo,

Mbaria,

Nyariki

et al. 2024

PLoS Negl Trop Dis

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“…The rate of new infections and mortality due to the disease show no sign of decline (Aksoy and Rio, 2005). Infection with trypanosomes results in the production of large amounts of reactive oxygen species (ROS) which are cytotoxic agents, damaging vital components of the cell, including proteins and lipids (Mishra et al, 2017;Ojo et al, 2021). The ROS generated attack the membrane lipids, resulting in their destruction and exhaustion of endogenous antioxidants that provide protection for cellular macromolecules (Kobo et al, 2014a).…”

Section: Introductionmentioning

confidence: 99%

Daflon 500 mg alone and its combination with diminazene aceturate inhibits alterations in lipid profile induced by Trypanosoma brucei brucei infection in Wistar rats

P. I.,

D.,

et al. 2024

NJAP

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The effect of Daflon® 500 mg (DF) and Diminazene aceturate (DZ) on the lipid profile of adult male Wistar rats infected with T. brucei brucei were investigated for their use in trypanosomosis. Fifty adult male Wistar rats were randomly divided into 5 groups of 10 rats each. Group I rats were treated with distilled water (1 mL/kg) per os, while group II rats were 6 intraperitoneally infected with T. brucei brucei (10 trypanosomes/mL of blood). Group III 6 rats were infected with T. brucei brucei (10 trypanosomes/mL of blood) and intraperitoneally administered with DZ at 3.5 mg/kg once, when infection was established. Groups IV and Vwere first pretreated with DF at 100 mg/kg per os for three weeks, followed 6 by infection with T. brucei brucei (10 trypanosomes/mL of blood) intraperitoneally. Treatment with DF continued for another one week. In addition, group V rats were intraperitoneally administered with DZ at 3.5 mg/kg once, when infection was established prior to continuation with DF for another one week. Pretreatment with DF alone or in combination with DZ decreased parasitaemia, lowered triglyceride level and significantly (P < 0.05) decreased cholesterol and low-density lipoprotein concentrations in T. brucei ® brucei-infected Wistar rats. In conclusion, daflon 500 mg alone or in combination with diminazene aceturate may be beneficial in the treatment of the infection in Wistar rats. L'effet du Daflon® 500 mg (DF) et de l'acéturate de diminazène (DZ) sur le profil lipidique de rats Wistar mâles adultes infectés par T. brucei brucei a été étudié pour leur utilisation dans la trypanosomose. Cinquante rats Wistar mâles adultes ont été répartis au hasard en 5 groupes de 10 rats chacun. Les rats du groupe I ont été traités avec de l'eau distillée (1 mL/kg) per os, tandis que les rats du groupe II ont été infectés par voie intrapéritonéale avec T. brucei brucei (106 trypanosomes/mLde sang). Les rats du groupe III ont été infectés par T. brucei brucei (106 trypanosomes/mL de sang) et administrés par voie intrapéritonéale avecdu DZ à raison de 3,5 mg/kg une fois, lorsque l'infection était établie. Les groupes IVet Vont d'abord été prétraités avec DF à 100 mg/kg per os pendant trois semaines, suivi d'une infection par T. brucei brucei (106 trypanosomes/mL de sang) par voie intrapéritonéale. Le traitement par DF s'est poursuivi pendant encore une semaine. De plus, des rats du groupe V ont reçu une administration intrapéritonéale de DZ à raison de 3,5 mg/kg une fois, lorsque l'infection était établie avant la poursuite du traitement par DF pendant une semaine supplémentaire. Le prétraitement avec DF seul ou en association avec DZ a diminué la parasitémie, abaissé le taux de triglycérides et significativement (P < 0,05) diminué les concentrations de cholestérol et de lipoprotéines de basse densité chez les rats Wistar infectés par T. brucei brucei. En conclusion, le daflon® 500 mg seul ou en association avec l'acéturate de diminazène pourrait être bénéfique dans le traitement de l'infection chez le rat Wistar

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Effects of astaxanthin alone or its combination with diminazene aceturate on the survivability and haematological parameters of Trypanosoma brucei brucei–infected Wistar rats

Kobo,

Suleiman,

Ayo

et al. 2024

Comp Clin Pathol

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Comprehensive analysis of oral administration of Vitamin E on the early stage of Trypanosoma brucei brucei infection

Cited by 4 publications

References 48 publications

Ginkgo biloba attenuated detrimental inflammatory and oxidative events due to Trypanosoma brucei rhodesiense in mice treated with melarsoprol

Ginkgo biloba attenuated detrimental inflammatory and oxidative events due to Trypanosoma brucei rhodesiense in mice treated with melarsoprol

Daflon 500 mg alone and its combination with diminazene aceturate inhibits alterations in lipid profile induced by Trypanosoma brucei brucei infection in Wistar rats

Effects of astaxanthin alone or its combination with diminazene aceturate on the survivability and haematological parameters of Trypanosoma brucei brucei–infected Wistar rats

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