Comprehensive Analysis of lncRNA and miRNA Expression Profiles and ceRNA Network Construction in Osteoporosis

Zhang, Xianzuo; Liang, Haiyi; Kourkoumelis, Nikolaos; Wu, Zhaodong; Li, Guoyuan; Shang, Xifu

doi:10.1007/s00223-019-00643-9

Cited by 23 publications

(28 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To identify biomarkers relative to osteoporosis disease, Zhang et al [ 81 ] characterized the competing endogenous RNA (ceRNA) regulatory networks of mRNAs, miRNAs, and long noncoding RNAs (lncRNAs) from microarray data obtained from the Gene Expression Omnibus database. They took into account the gene expression profile from circulating monocytes of five subjects with high hip BMD compared with five subjects with low hip BMD.…”

Section: Mirnas In Human Circulating Monocytesmentioning

confidence: 99%

Circulating miRNAs: A New Opportunity in Bone Fragility

et al. 2020

View full text Add to dashboard Cite

Osteoporosis, one of the leading causes of bone fractures, is characterized by low bone mass and structural deterioration of bone tissue, which are associated with a consequent increase in bone fragility and predisposition to fracture. Current screening tools are limited in estimating the proper assessment of fracture risk, highlighting the need to discover novel more suitable biomarkers. Genetic and environmental factors are both implicated in this disease. Increasing evidence suggests that epigenetics and, in particular, miRNAs, may represent a link between these factors and an increase of fracture risk. miRNAs are a class of small noncoding RNAs that negatively regulate gene expression. In the last decade, several miRNAs have been associated with the development of osteoporosis and bone fracture risk, opening up new possibilities in precision medicine. Recently, these molecules have been identified in several biological fluids, and the possible existence of a circulating miRNA (c-miRNA) signature years before the fracture occurrence is suggested. The aim of this review is to provide an overview of the c-miRNAs suggested as promising biomarkers for osteoporosis up until now, which could be helpful for early diagnosis and monitoring of treatment response, as well as fracture risk assessment, in osteoporotic patients.

show abstract

Section: Mirnas In Human Circulating Monocytesmentioning

confidence: 99%

Circulating miRNAs: A New Opportunity in Bone Fragility

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Long non-coding RNAs (lncRNAs) are a class of non-protein-coding RNA transcripts with lengths longer than 200 nucleotides. Growing amounts of evidences have shown that lncRNAs are important regulators in diverse biological processes and diseases including osteoporosis 5 – 7 . A good number of lncRNAs have been demonstrated to play critical roles in the osteogenic differentiation of BMSCs 8 – 10 .…”

Section: Introductionmentioning

confidence: 99%

Long non-coding RNA MIR22HG promotes osteogenic differentiation of bone marrow mesenchymal stem cells via PTEN/ AKT pathway

et al. 2020

View full text Add to dashboard Cite

Osteoporosis is a prevalent metabolic bone disease characterized by low bone mineral density and degenerative disorders of bone tissues. Previous studies showed the abnormal osteogenic differentiation of endogenous bone marrow mesenchymal stem cells (BMSCs) contributes to the development of osteoporosis. However, the underlying mechanisms by which BMSCs undergo osteogenic differentiation remain largely unexplored. Recently, long non-coding RNAs have been discovered to play important roles in regulating BMSC osteogenesis. In this study, we first showed MIR22HG, which has been demonstrated to be involved in the progression of several cancer types, played an important role in regulating BMSC osteogenesis. We found the expression of MIR22HG was significantly decreased in mouse BMSCs from the osteoporotic mice and it was upregulated during the osteogenic differentiation of human BMSCs. Overexpression of MIR22HG in human BMSCs enhanced osteogenic differentiation, whereas MIR22HG knockdown inhibited osteogenic differentiation both in vitro and in vivo. Mechanistically, MIR22HG promoted osteogenic differentiation by downregulating phosphatase and tensin homolog (PTEN) and therefore activating AKT signaling. Moreover, we found MIR22HG overexpression promoted osteoclastogenesis of RAW264.7 cells, which indicated that MIR22HG played a significant role in bone metabolism and could be a therapeutic target for osteoporosis and other bone-related diseases.

show abstract

“…Zeng et al conducted a meta-analysis among individuals of seven independent studies for BMD, reporting that MEF2C antisense RNA 1 (MEF2C-AS1) was significantly associated with BMD of femoral neck, while LOC100506136 showed significant association with BMD of hip [12]. Similarly, Zhang et al constructed a comprehensive mRNA-lncRNA-miRNA competing endogenous RNA (ceRNA) regulatory network to predict the risk of osteoporosis development by analyzing public Gene Expression Omnibus (GEO) microarray profile data [13]. In the next paragraphs, we provide information about the mechanisms and the role of non-coding RNAs in the regulation of gene expression and their link with extracellular vesicles (EVs) in the onset of osteoporosis.…”

Section: Introductionmentioning

confidence: 99%

The Role of Extracellular Vesicles (EVs) in the Epigenetic Regulation of Bone Metabolism and Osteoporosis

Muraca

Cappariello

2020

IJMS

View full text Add to dashboard Cite

Extracellular vesicles (EVs) are complex phospholipidic structures actively released by cells. EVs are recognized as powerful means of intercellular communication since they contain many signaling molecules (including lipids, proteins, and nucleic acids). In parallel, changes in epigenetic processes can lead to changes in gene function and finally lead to disease onset and progression. Recent breakthroughs have revealed the complex roles of non-coding RNAs (microRNAs (miRNAs) and long non-coding RNAs (lncRNAs)) in epigenetic regulation. Moreover, a substantial body of evidence demonstrates that non-coding RNAs can be shuttled among the cells and tissues via EVs, allowing non-coding RNAs to reach distant cells and exert systemic effects. Resident bone cells, including osteoclasts, osteoblasts, osteocytes, and endothelial cells, are tightly regulated by non-coding RNAs, and many of them can be exported from the cells to neighboring ones through EVs, triggering pathological conditions. For these reasons, researchers have also started to exploit EVs as a theranostic tool to address osteoporosis. In this review, we summarize some recent findings regarding the EVs’ involvement in the fine regulation of non-coding RNAs in the context of bone metabolism and osteoporosis.

show abstract

Comprehensive Analysis of lncRNA and miRNA Expression Profiles and ceRNA Network Construction in Osteoporosis

Cited by 23 publications

References 42 publications

Circulating miRNAs: A New Opportunity in Bone Fragility

Circulating miRNAs: A New Opportunity in Bone Fragility

Long non-coding RNA MIR22HG promotes osteogenic differentiation of bone marrow mesenchymal stem cells via PTEN/ AKT pathway

The Role of Extracellular Vesicles (EVs) in the Epigenetic Regulation of Bone Metabolism and Osteoporosis

Contact Info

Product

Resources

About