Comprehensive Analysis of Left Ventricular Geometry and Function by Three-Dimensional Echocardiography in Healthy Adults

Muraru, Denisa; Badano, Luigi P.; Peluso, Diletta; Bianco, Lucia Dal; Casablanca, S.; Kocabay, Gönenç; Zoppellaro, Giacomo; Iliceto, Sabino

doi:10.1016/j.echo.2013.03.014

Cited by 129 publications

(113 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The apparent discrepancy may be related to clinical differences in the cohorts or to differences in how LV mass was determined between the two studies (cardiac MR imaging versus two-dimensional echocardiography). More recently, cross-sectional data from three-dimensional echocardiography revealed no significant change between LV mass and age in either men or women (25). In the same cross-sectional study (25), LV EDV decreased with age so that mass-to-volume ratio was observed to increase with age in both men and women, similar to findings in the present study.…”

Section: Cardiac Imaging: Adverse Left Ventricular Remodelingsupporting

confidence: 79%

“…The longitudinal decrease in LV EDV and stroke volume we observed in participants who underwent follow-up is consistent with cross-sectional age relationships reported in the MESA cohort at baseline (13). More recent cross-sectional studies in healthy volunteers with three-dimensional echocardiography have shown an inverse relationship between LV volume and age (25)(26)(27). These volume relationships are in contrast to the findings of earlier studies that reported LV volume increased with age (28,29).…”

Section: Cardiac Imaging: Adverse Left Ventricular Remodelingcontrasting

confidence: 57%

See 1 more Smart Citation

Adverse Left Ventricular Remodeling and Age Assessed with Cardiac MR Imaging: The Multi-Ethnic Study of Atherosclerosis

Eng

McClelland²,

Gomes

et al. 2016

Radiology

View full text Add to dashboard Cite

).q RSNA, 2015 Purpose:To evaluate age-related left ventricular (LV) remodeling during longitudinal observation of a large cohort of asymptomatic individuals who were free of clinical cardiovascular disease at baseline. Materials and Methods:The applicable institutional review boards approved this study, and all participants gave informed consent. Cardiac magnetic resonance (MR) imaging was used to identify longitudinal changes in LV structure and function in 2935 participants who underwent baseline and follow-up cardiac MR imaging in the Multi-Ethnic Study of Atherosclerosis. Participants were free of clinical cardiovascular disease at baseline. Participants who experienced an incident coronary heart disease event were excluded. Data were analyzed with multivariable mixed-effects regression models in which the outcome was cardiac MR imaging measurement, and the covariates included follow-up time and cardiac risk factors. Results:Participants were aged 54-94 years at follow-up, and 53% of the participants were women. Median time between baseline and follow-up cardiac MR imaging was 9.4 years. Over this period, LV mass increased in men and decreased slightly in women (8.0 and 21.6 g per decade, respectively; P , .001). In both men and women, LV enddiastolic volume decreased (29.8 and 213.3 mL per decade, respectively; P , .001), stroke volume decreased (28.8 and 28.6 mL per decade, respectively; P , .001), and mass-to-volume ratio increased (0.14 and 0.11 g/mL per decade, respectively; P , .001). Change in LV mass was positively associated with systolic blood pressure and body mass index and negatively associated with treated hypertension and high-density lipoprotein cholesterol level. In men, the longitudinal LV mass increase was in contrast to a cross-sectional pattern of LV mass decrease. Conclusion:As patients age, the LV responds differently in its mass and volume between men and women, although both men and women experience increased concentric LV remodeling with age. In men, the opposition of longitudinal and cross-sectional changes in LV mass highlights the importance of longitudinal study.q RSNA, 2015

show abstract

Section: Cardiac Imaging: Adverse Left Ventricular Remodelingsupporting

confidence: 79%

Section: Cardiac Imaging: Adverse Left Ventricular Remodelingcontrasting

confidence: 57%

Adverse Left Ventricular Remodeling and Age Assessed with Cardiac MR Imaging: The Multi-Ethnic Study of Atherosclerosis

Eng

McClelland²,

Gomes

et al. 2016

Radiology

View full text Add to dashboard Cite

show abstract

“…LVEF in the range of 53-73% should be classified as normal. [22][23][24][25][26] A revision of the current guideline incorporating these new data is being completed as of this writing. Changes in LVEF indicative of LV damage can be more appropriately identified when comparisons are made between baseline and follow-up studies.…”

Section: A Left Ventricular Systolic Functionmentioning

confidence: 99%

“…† A pretreatment assessment may help cardiologists advise oncologists as to known or anticipated risks. † If the LVEF is ,53%, [22][23][24][25][26] GLS is below the limit of normal (Table 5), and/or troponins are elevated, a cardiology consultation should be considered, with discussion between the cardiologist and oncologist of the risk/benefit ratio, and cancer treatment at the discretion of the oncologist (Figures 13 -15). † If the quality of the echocardiogram is sub-optimal, CMR is recommended.…”

Section: Integrated Approachmentioning

confidence: 99%

Expert Consensus for Multimodality Imaging Evaluation of Adult Patients during and after Cancer Therapy: A Report from the American Society of Echocardiography and the European Association of Cardiovascular Imaging

Plana

Galderisi

Barac

et al. 2014

Journal of the American Society of Echocardiography

Self Cite

1,281

1,209

View full text Add to dashboard Cite

“…Only recently, large analyses of LV parameters using 3DE in large cohorts of healthy individuals have been published to establish race, age and gender-specific reference ranges to facilitate the standardisation of this technique. 6 The most commonly used strain-based measure of LV global systolic function is global longitudinal strain (GLS), which is usually assessed by speckle-tracking echocardiography and describes the relative length change of the LV myocardium between end-diastole and end-systole.…”

Section: Systolic Functionmentioning

confidence: 99%

Novel Imaging Techniques for Heart Failure

Melero-Ferrer

López‐Vilella

Morillas-Climent

et al. 2016

Cardiac Failure Review

View full text Add to dashboard Cite

Heart failure (HF) is an epidemic with an increasing prevalence and an absolute mortality rate of approximately 50 % within 5 years of diagnosis. Imaging plays a main role in HF diagnosis, assessment of aetiology and treatment guidance. This article reviews current HF applications for all the available non-invasive imaging modalities: echocardiography, cardiovascular magnetic resonance (CMR), nuclear imaging-positron emission tomography (PET) and single-photon emission computed tomography (SPECT) and computed tomography (CT). Echocardiography, with its recent developments, such as 3D echo, is the main imaging test used in the evaluation of HF patients, given its availability and reliability in assessing cardiac structure and function. CMR allows the characterisation of myocardial tissue, in addition to providing information on the structure and cardiac function, so it is a great help in the determination of HF aetiology and may predict patient outcomes. Nuclear imaging can detect ischaemia and viability and can obtain additional prognostic data. Cardiac CT is EchocardiographyAlthough echocardiography is a relatively 'ancient' technique, its versatility makes it unique in the provision of volumes, function, haemodynamics or valvular regurgitation. In addition, because of its availability, safety and low cost, echocardiography is the first and most widely used test for the diagnosis, selection of appropriate treatment and prognosis of HF.1 Echocardiography is also the most used imaging method in the reassessment of HF patients. It remains unclear when to repeat echocardiographic exams, but it is deemed appropriate at least in patients with worsening symptoms. Systolic FunctionGlobal left ventricular (LV) function is of paramount importance regarding therapeutic decisions. Visual estimation of ejection fraction (EF), the Teichholz and Simpson methods, have been widely validated. 2,3However, in 2D imaging, because of its operator-dependent nature, repeated testing has a high probability of producing variable volume and EF results.The apparition of 3D fully sampled matrix transthoracic echocardiography has enabled easier acquisition of images, 4 simplifying its routinary application. There have been many studies comparing 2D and 3D echocardiography (2DE and 3DE) and a 'reference' standard (generally CMR). A recent meta-analysis of all 3DE studies evaluating LV volumes and EF demonstrated that 3DE generally underestimated volumes, but not as significantly as 2DE. There was also less variability than 2D compared with CMR.5 Nonetheless, 3DE echocardiography may be challenging and not practical in patients with low image quality (e.g. critical patients), in whom 2DE measures are more realiable. 3DE is also a less standardised techique than 2DE, and because of this reason most laboratories use the more universally applicable 2DE measurements in clinical practice. Only recently, large analyses of LV parameters using 3DE in large cohorts of healthy individuals have been published to establish race, age and gender-specific ...

show abstract

Comprehensive Analysis of Left Ventricular Geometry and Function by Three-Dimensional Echocardiography in Healthy Adults

Cited by 129 publications

References 38 publications

Adverse Left Ventricular Remodeling and Age Assessed with Cardiac MR Imaging: The Multi-Ethnic Study of Atherosclerosis

Adverse Left Ventricular Remodeling and Age Assessed with Cardiac MR Imaging: The Multi-Ethnic Study of Atherosclerosis

Expert Consensus for Multimodality Imaging Evaluation of Adult Patients during and after Cancer Therapy: A Report from the American Society of Echocardiography and the European Association of Cardiovascular Imaging

Novel Imaging Techniques for Heart Failure

Contact Info

Product

Resources

About